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Human L1CAM Protein expressed in Human Cells - ABIN2002161
Rosenthal, Jouet, Kenwrick: Aberrant splicing of neural cell adhesion molecule L1 mRNA in a family with X-linked hydrocephalus. in Nature genetics 1993
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In uterine carcinosarcoma, membranous L1CAM expression was positive in the epithelial component in 65.4% of cases. Remarkably, expression was negative in the mesenchymal component. In cases where both components were intermingled, expression limited to the epithelial component was confirmed by a double stain for L1CAM and keratin. Expression of L1CAM did not relate to overall or disease-free survival.
Our findings suggest that L1CAM is possibly involved in the pathogenesis of at least a subset of endometrial clear cell carcinomas
The directional force for laminin-induced growth cone haptotaxis is generated by the grip and slip of L1-CAM on the substrates, which occur asymmetrically under the growth cone.
L1CAM promotes esophageal squamous cell carcinoma tumorigenicity by upregulating ezrin (show EZR Proteins) expression.
TWIST1 (show TWIST1 Proteins), in part via GAS6 (show GAS6 Proteins) and L1CAM, led to higher expression and activation of Akt (show AKT1 Proteins) upon cisplatin treatment, and inhibition of Akt (show AKT1 Proteins) activation sensitized cells to cisplatin.
data make L1CAM a highly interesting therapeutic target to prevent further metastatic spread in melanoma patients
High circulating levels of autoantibodies against L1-cell adhesion molecule is associated with esophageal squamous cell carcinoma.
A functional role for L1CAM in extrahepatic cholangiocarcinoma carrying the activating KRAS mutation.L1CAM prmotes cell migration and invasion via JNK (show MAPK8 Proteins) activation in extrahepatic cholangiocarcinoma.
this review and meta-analysis concludes that L1CAM might be an effective poor prognostic factor for patients with various tumor types
High L1CAM expression is associated with vulvar squamous cell carcinomas.
The present study provides evidence for a novel L1-mediated function of MBP (show MBP Proteins) in the developing spinal cord and in the injured adult mammalian nervous system that leads to enhanced recovery after acute trauma.
induced expression of L1CAM or PSA (show NPEPPS Proteins)-NCAM (show NCAM1 Proteins) in the iPSC-derived DA neurons cannot completely restore the neurite outgrowth potential that was reduced in these DA neurons as a consequence of epigenetic aberrations resulting from the iPSC reprogramming process.
Heterozygous L1CAM-deficient mice express an autism-like phenotype.
tumors in stressed animals demonstrated markedly enhanced expression of VEGFR-2 (show KDR Proteins) and L1CAM mRNA as well as pERK (show EIF2AK3 Proteins), MMP-2 (show MMP2 Proteins) and MMP-9 (show MMP9 Proteins) protein expression.
Function-triggering antibodies to the adhesion molecule (show NCAM1 Proteins) L1 enhance recovery after injury of the adult mouse femoral nerve.
We suggest that L1 stimulates neuritogenesis by activating CK2alpha leading to decreased levels of PTEN and p53 (show TP53 Proteins) via a novel, L1-triggered and CK2alpha-mediated signal transduction pathway.
a positive relationship between L1 and pPKD1 in both cultured cerebellar neurons and human cerebellar tissue, suggesting that L1 functions in the modulation of PKD1 (show PKD1 Proteins) phosphorylation.
Myelin basic protein (show MBP Proteins) cleaves cell adhesion molecule (show MCAM Proteins) L1 and promotes neuritogenesis and cell survival.
These results demonstrate that L1 promotes neuronal differentiation from ESCs (show NR2E3 Proteins) through the L1-mediated enhancement of FUT9 (show FUT9 Proteins) and ST3Gal4 (show ST3GAL4 Proteins) expression.
L1 stimulation triggers sumoylation and cleavage of L1, thus generating the L1-70 fragment which is cleaved by cathepsin E (show CTSE Proteins)
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
neural cell adhesion molecule L1
, antigen identified by monoclonal antibody R1
, N-CAM L1
, nerve-growth factor-inducible large external glycoprotein
, neuron-glia cell adhesion molecule (Ng-CAM)
, neuronal-glial cell adhesion molecule