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Human L1CAM Protein expressed in Human Cells - ABIN2002161
Rosenthal, Jouet, Kenwrick: Aberrant splicing of neural cell adhesion molecule L1 mRNA in a family with X-linked hydrocephalus. in Nature genetics 1993
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L1CAM is overexpressed in pancreatic ductal adenocarcinoma cells and in adjacent Schwann cells in invaded nerves. L1CAM from these SC acts as a strong chemoattractant to cancer cells, via activation of MAP kinase signaling. L1CAM also upregulated expression of MMP-2 and MMP-9 by PDAC cells, via STAT3 activation. There is a paracrine response between SCs and cancer cells in the neural niche, promoting invasion via L1CAM.
Our results demonstrate the expression of L1CAM and miR-34a in EC as prognostic factors that identify subgroup of patients at high risk of recurrence suggesting for them more aggressive schedules of treatment.
the present study identified two novel pathogenic class II variants in L1CAM in two Chinese families with a history of hydrocephaly.
L1CAM is a promising independent prognostic marker associated with aggressive tumor behavior and recurrence risk, but not with overall survival
In uterine carcinosarcoma, membranous L1CAM expression was positive in the epithelial component in 65.4% of cases. Remarkably, expression was negative in the mesenchymal component. In cases where both components were intermingled, expression limited to the epithelial component was confirmed by a double stain for L1CAM and keratin. Expression of L1CAM did not relate to overall or disease-free survival.
Our findings suggest that L1CAM is possibly involved in the pathogenesis of at least a subset of endometrial clear cell carcinomas
The directional force for laminin-induced growth cone haptotaxis is generated by the grip and slip of L1-CAM on the substrates, which occur asymmetrically under the growth cone.
L1CAM promotes esophageal squamous cell carcinoma tumorigenicity by upregulating ezrin expression.
TWIST1, in part via GAS6 and L1CAM, led to higher expression and activation of Akt upon cisplatin treatment, and inhibition of Akt activation sensitized cells to cisplatin.
data make L1CAM a highly interesting therapeutic target to prevent further metastatic spread in melanoma patients
High circulating levels of autoantibodies against L1-cell adhesion molecule is associated with esophageal squamous cell carcinoma.
A functional role for L1CAM in extrahepatic cholangiocarcinoma carrying the activating KRAS mutation.L1CAM prmotes cell migration and invasion via JNK activation in extrahepatic cholangiocarcinoma.
this review and meta-analysis concludes that L1CAM might be an effective poor prognostic factor for patients with various tumor types
High L1CAM expression is associated with vulvar squamous cell carcinomas.
Our preclinical assessment of the CE7 epitope on CD171 supports its utility and safety as a CAR T-cell target for neuroblastoma immunotherapy
L1CAM may have a role in human endometrial cancer and miR-34a has an inverse role to L1CAMEXP
L1CAM mRNA expression appears to play a substantial role in the pathophysiology of ovarian cancer that is translated into poor clinical outcome.
These results suggest that a deficiency in L1 may partially account for RTT phenotypes.
L1CAM failed to be a clinically relevant marker of poor prognosis in stage I endometrioid endometrial carcinoma
This study revealed an unexpected role of L1CAM in the pathological crosstalk between the immune and nervous systems.
the interplay of nuclear L1 and distinct nuclear receptors is associated with synaptic contact formation and plasticity.
The present study provides evidence for a novel L1-mediated function of MBP in the developing spinal cord and in the injured adult mammalian nervous system that leads to enhanced recovery after acute trauma.
L1 contributes to functional expression and localization of Na(+) channels to the neuronal plasma membrane, ensuring correct initiation of action potential and normal firing activity
induced expression of L1CAM or PSA-NCAM in the iPSC-derived DA neurons cannot completely restore the neurite outgrowth potential that was reduced in these DA neurons as a consequence of epigenetic aberrations resulting from the iPSC reprogramming process.
Heterozygous L1CAM-deficient mice express an autism-like phenotype.
tumors in stressed animals demonstrated markedly enhanced expression of VEGFR-2 and L1CAM mRNA as well as pERK, MMP-2 and MMP-9 protein expression.
Function-triggering antibodies to the adhesion molecule L1 enhance recovery after injury of the adult mouse femoral nerve.
We suggest that L1 stimulates neuritogenesis by activating CK2alpha leading to decreased levels of PTEN and p53 via a novel, L1-triggered and CK2alpha-mediated signal transduction pathway.
a positive relationship between L1 and pPKD1 in both cultured cerebellar neurons and human cerebellar tissue, suggesting that L1 functions in the modulation of PKD1 phosphorylation.
endothelial L1 orchestrates multiple cancer vessel functions, including tumor angiogenesis and preventing vessel normalization
Myelin basic protein cleaves cell adhesion molecule L1 and promotes neuritogenesis and cell survival.
We conclude that neuronal overexpression of L1 improves functional recovery from spinal cord injury
L1+/- mice display an unexpected phenotype that is not an intermediate between L1+/+ mice and mice deficient in L1 (L1-/y).
the right context, Olfactory ensheathing cells-derived PM factors could enhance corticospinal tract axonal regeneration
These results demonstrate that L1 promotes neuronal differentiation from ESCs through the L1-mediated enhancement of FUT9 and ST3Gal4 expression.
L1 stimulation triggers sumoylation and cleavage of L1, thus generating the L1-70 fragment which is cleaved by cathepsin E
the neurite outgrowth promoted by Neural Cell Adhesion Molecule L1 was strongly inhibited by siRNA against FGF21 gene or a treatment of cells with FGFR inhibitor
we investigated the role of L1CAM during metastasis formation
neuregulin 1-beta (Nrg1beta) increases L1 expression in neurons of the cerebral cortex, and decreases expression in neurons of the hippocampus in vitro and in vivo.
L1 thus appears to be a candidate molecule to ameliorate the pathology of Alzheimer's disease
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
neural cell adhesion molecule L1
, antigen identified by monoclonal antibody R1
, N-CAM L1
, nerve-growth factor-inducible large external glycoprotein
, neuron-glia cell adhesion molecule (Ng-CAM)
, neuronal-glial cell adhesion molecule