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|Antigen||Leucine Rich Repeat and Fibronectin Type III Domain Containing 1 (LRFN1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
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|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human LRFN1|
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|Alternative Name||Lrfn1 (LRFN1 Antibody Abstract)|
LRFN1 is a 771 amino acid single-pass type I membrane protein that belongs to the LRFN family. Containing a fibronectin type-III domain, an Ig-like (immunoglobulin-like) domain, a LRRCT domain, a LRRNT domain and seven LRR (leucine-rich) repeats, LRFN1 is thought to promote neurite outgrowth in hippocampal neurons and is involved in the regulation and maintenance of excitatory synapses. LRFN1 forms heteromeric complexes with LRFN2, LRFN3, LFRN4 and LFRN5, but does not have the ability to form homomeric complexes across cell junctions of adjacent cells like other LRFN family members. The PDZ-binding motif of LRFN1 is required for neurite outgrowth promotion and for SAP 97-, NE-dlg- and PSD-95-binding. LRFN1 is encoded by a gene located on human chromosome 19q13.2 and mouse chromosome 7 A3.
Subcellular location: Extracellular
Synonyms: Leucine rich repeat and fibronectin type III domain containing 1, Leucine rich repeat and fibronectin type III domain containing protein 1, Leucine-rich repeat and fibronectin type III domain-containing protein 1, LRFN 1, lrfn1, LRFN1_HUMAN, SALM 2, SALM2, Synaptic adhesion like molecule 2, Synaptic adhesion-like molecule 2.
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|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
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|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|