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Following EGF stimuli, the D domain of LRRC4 anchors ERK1/2 in the cytoplasm and abrogates ERK1/2 activation and nuclear translocation.
polymorphisms and haplotypes in the LRRC4 may have a role in pituitary adenoma in a Chinese population
Disturbing miR (show MLXIP Proteins)-182 and -381 inhibits BRD7 (show BRD7 Proteins) transcription and glioma growth by directly targeting LRRC4.
LRRC4 inhibited the miR (show MLXIP Proteins)-185 pathway function in glioma
Potentially, modulation of LRRC4 or STMN1 (show STMN1 Proteins) expression may be useful for design of new therapies for the intervention of glioma
As a glioma suppressor, LRRC4 inhibits the endogenous expression of small regulatory microRNA hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-381 and decreases cell proliferation and tumor growth in cultured glioma cells.
LRRC4 may play an important role in maintaining normal function and suppressing tumorigenesis in the central nervous system.
LRRC4 gene might be involved in tumor suppression by restraining DNA synthesis and nucleoli organizer regions-associated proteins.
these studies represent the first cDNA array analysis of the effects of LRRC4 on the involvement of different neurobiological genes in U251MG glioblastoma cells and provide new insights into the function of LRRC4 in glioma
LRRC4 plays a major role in suppressing U251 cell proliferation by regulating the extracellular signal-regulated kinase (ERK (show EPHB2 Proteins))/Akt (show AKT1 Proteins)/NF-kappaBp65, STAT3 (show STAT3 Proteins), and JNK2 (show MAPK9 Proteins)/c-Jun (show JUN Proteins) pathways.
our results identify NGL-2 as a central component of pathway-specific development in the outer retina.
These results demonstrate that NGL-2 is critical for pathway-specific synapse development and functional integration of distinct inputs.
Together, these findings provide clues to the function of LRRC4 as a negative regulator of cell growth and underscore a link between the above-mentioned cyclins, cyclin (show PCNA Proteins)-associated molecules and tumorigenicity.
This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown.
brain tumor associated protein LRRC4
, brain tumor-associated protein BAG
, leucine-rich repeat-containing 4
, leucine-rich repeat-containing protein 4
, nasopharyngeal carcinoma-associated gene 14 protein
, netrin-G2 ligand
, leucine rich repeat containing 4 protein
, netrin-G1 ligand
, LIBG-like protein
, LRRC4-like protein
, brain tumor-associated protein MBAG1
, protein NGL-2