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anti-Rat (Rattus) LRRC7 Antibodies:
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Rat (Rattus) Polyclonal LRRC7 Primary Antibody for ICC - ABIN1742390
Wheeler, Groth, Ma, Barrett, Owen, Safa, Tsien: Ca(V)1 and Ca(V)2 channels engage distinct modes of Ca(2+) signaling to control CREB-dependent gene expression. in Cell 2012
The important role of this gene in the synapse and mental illness endophenotypes observed in animal models suggests that LRRC7 may play a role in susceptibility to bipolar disorder.
Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
We found no genome-wide statistically significant associations but identified several plausible candidate genes among findings at p < 5E-05: LRRC7, TMEM132D, SEMA3A, ALK, and STIP1.
Densin-180 co-localized with delta-catenin/NPRAP at synapses in delta-catenin/NPRAP and may be involved in organization of the synaptic cell-cell junction through interaction with the delta-catenin/NPRAP-N-cadherin complex
A novel splice variant, LRRC7, of densin-180 is located on 1p31 and consists of 8 exons. Unlike wild type, not brain-specific.
expressed by glomerular podocytes and has a role in associating with the nephrin interacting protein complex at the slit diaphragm
Densin can act as autoantigen, and autoantibodies against these can be detected in patients with type 1 diabetes.
Densin is a novel testicular protein expressed in the cell membranes of Sertoli cells.
Densin may associate with the cadherin-catenin and nephrin complex(es), and may be involved in the formation of the cell-cell contacts.
common variants in LRRC7, KIRREL, NPHS2 and ACTN4 do not appeear to contribute to susceptibility to diabetic nephropathy in Finnish patients with type 1 diabetes
We report that the protein densin-180 is highly enriched at excitatory synapses in the brain and enhances the cell surface trafficking and postsynaptic localization of Cav1.2 L-type Ca(2+) channels in neurons. This interaction promotes coupling of Cav1.2 channels to activity-dependent gene transcription.
This study demonstrated that Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction.
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression (By similarity).
leucine rich repeat containing 7
, leucine-rich repeat-containing protein 7-like
, densin 13T-16
, densin 13T-17
, densin 13T-23
, densin 13T-29
, densin 13T-41
, densin 13T-43
, densin 13T-57
, densin 13T-57C
, densin 13T-72
, densin 13T-89
, leucine-rich repeat-containing protein 7
, densin 180