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missense variant in the LZTS1 gene was identified in two Ehlers-Danlos syndrome patients in an extended family.
LZTS1 promoter was frequently methylated in IMPC samples.
Compared with the normal hepatocyte cells, LZTS1 expression in hepatocellular carcinoma cells was significantly lower
miR (show MLXIP Proteins)-135b expression inversely correlated with LZTS1 staining intensity and the Cutaneous Squamous Cell Carcinoma grade.
Suggest that LZTS1 plays a potential tumor suppressor role in colorectal cancer progression and represents a valuable clinical prognostic marker of this disease.
Lzts1 was significantly downregulated in breast cancer samples and its deregulation was associated with a higher incidence of tumor recurrence, and to a worse overall survival.
miR (show MLXIP Proteins)-214 functions as an onco-miRNA in osteosarcoma, and its oncogenic effects are mediated chiefly through downregulation of LZTS1
Expression of miR (show MLXIP Proteins)-135b, LZTS1, LATS2 and nuclear TAZ (show TAZ Proteins) predicts poor outcomes of non-small-cell lung cancer.
Lower levels of leucine zipper putative tumor suppressor 1 correlated with high histologic grade, lymph node metastasis, and poor prognosis.
Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity is associated with oral squamous cell carcinomas
The results of this study provide a novel Rap2 (show RAP2A Proteins)-specific regulatory mechanism in synaptic maturation involving PSD-Zip70.
Taken together, the spatial and temporal distribution of Lzts1 is consistent with a potential function(s) in cell cycle regulation, axon growth or guidance, and/or migration of neurons.
Lzts1 deficiency was associated with an increased incidence of both spontaneous and carcinogen-induced cancers in mice.
Partial or complete loss of Lzts1 downregulates Cdc25C (show CDC25C Proteins) and inhibits Cdk1 (show CDK1 Proteins) activity during mitosis, leading to premature transition from metaphase to anaphase.
Loss of one or both LZTS1 alleles hampers the normal defenses of urothelial cells against carcinogens, favoring bladder cancer development, which may make FEZ1 (show FEZ1 Proteins) a target for gene therapy.
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer.
F37/Esophageal cancer-related gene-coding leucine-zipper motif
, leucine zipper putative tumor suppressor 1
, F37 esophageal cancer-related leucine zipper motif 1
, leucine-zipper protein FEZ1
, leucine zipper, putative tumor suppressor 1
, leucine zipper putative tumor suppressor 1-like