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Show all synonyms
Mice with reduced SynDIG1 exhibit deficits in the structure and function of excitatory synapses. Mature synapses are still present, albeit at a significantly reduced number, suggesting that synapses can reach maturity without SynDIG1. However, the overall reduction in the number of mature synapses by multiple criteria suggests that SynDIG1 is important for normal development.
This study provides mechanistic insight into SynDIG1 structure and function to demonstrate that its stability and subcellular localization are regulated by activity-dependent palmitoylation
May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation (By similarity).
dispanin subfamily C member 2
, synapse differentiation-inducing gene protein 1
, transmembrane protein 90B
, interferon induced transmembrane protein domain containing 5
, synapse differentiation induced gene 1