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General |
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Antigen | Caspase Recruitment Domain Family, Member 11 (CARD11) Antibodies |
Reactivity | Human, Mouse (Murine), Rat (Rattus) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This CARD11 antibody is un-conjugated Alternatives |
Application |
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Alternatives
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Supplier | Log in to see |
Product Details anti-CARD11 AntibodyTarget Details CARD11 Application Details Handling Images |
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Purification | Purified by Protein A. |
Immunogen | KLH conjugated synthetic peptide derived from human CARD11 |
Isotype | IgG |
Plasmids, Primers & others | |
Target Details CARD11Product Details anti-CARD11 Antibody Application Details Handling Images back to top |
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Antigen | |
Alternative Name | Card11 (CARD11 Antibody Abstract) |
Background |
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Synonyms: Bcl10 interacting maguk protein 3, BIMP 3, BIMP3, CAR11_HUMAN, CARD 11, CARD containing MAGUK protein 3, Card maguk protein 1, CARD-containing MAGUK protein 1, CARD11, CARD11 protein, Carma 1, CARMA1, Caspase recruitment domain containing protein 11, Caspase recruitment domain family member 11, Caspase recruitment domain-containing protein 11, MGC133069. |
Gene ID | 84433 |
Pathways | TCR Signaling, Fc-epsilon Receptor Signaling Pathway |
Application DetailsProduct Details anti-CARD11 Antibody Target Details CARD11 Handling Images back to top |
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Application Notes |
WB 1:100-1000 IHC-P 1:100-500 IF(IHC-P) 1:50-200 |
Restrictions | For Research Use only |
HandlingProduct Details anti-CARD11 Antibody Target Details CARD11 Application Details Images back to top |
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Format | Liquid |
Concentration | 1 μg/μL |
Buffer | Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide. |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only. |
Storage | -20 °C |
Storage Comment | Store at -20°C |
Expiry Date | 12 months |