anti-Human CBL antibody for Enzyme Immunoassay

Recommended CBL Antibody (supplied by: Log in to see )

Antigen
Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Antibodies
  • 4732447J05Rik
  • Cbl-2
  • c-Cbl
  • cbl
  • C-CBL
  • CBL2
  • FRA11B
  • NSLL
  • RNF55
  • c-cbl-like
  • RGD1561386
  • Casitas B-lineage lymphoma
  • Cbl proto-oncogene
  • Cbl
  • CBL
Reactivity
Human, Mouse (Murine), Rat (Rattus)
307
197
176
5
4
4
4
3
3
1
1
1
Host
Mouse
261
35
17
1
Clonality
Monoclonal
Conjugate
This CBL antibody is un-conjugated
8
8
8
7
6
6
5
5
5
5
5
5
5
5
5
4
2
2
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
219
105
100
65
61
49
20
18
15
11
5
3
3
2
1
1
Supplier
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Catalog No. ABIN1105707
$ 423.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN5552703 EIA WB Goat C-Term Log in to see Polyclonal 0
1 ABIN5554671 EIA IF WB Rabbit IgG C-Term Log in to see Polyclonal 0

General

Antigen Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(307), (197), (176), (5), (4), (4), (4), (3), (3), (1), (1), (1)
Host Mouse
(261), (35), (17), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CBL antibody is un-conjugated
(8), (8), (8), (7), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (2), (2), (1)
Application Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(219), (105), (100), (65), (61), (49), (20), (18), (15), (11), (5), (3), (3), (2), (1), (1)
Pubmed 3 references available
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Product Details anti-CBL Antibody

Target Details CBL Application Details Handling References for anti-CBL antibody (ABIN1105707) Images
Specificity This antibody reacts to C-CBL.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse and Rat.
Purification Ascites
Clone 3B12
Isotype IgG1
Plasmids, Primers & others

Target Details CBL

Product Details anti-CBL Antibody Application Details Handling References for anti-CBL antibody (ABIN1105707) Images back to top
Antigen
Alternative Name CBL / RNF55 (CBL Antibody Abstract)
Background The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.Synonyms: CBL2, Casitas B-lineage lymphoma proto-oncogene, E3 ubiquitin-protein ligase CBL, Proto-oncogene c-CBL, RING finger protein 55, Signal transduction protein CBL, c-CBL
Molecular Weight 120 kDa
Gene ID 867
Pathways TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals

Application Details

Product Details anti-CBL Antibody Target Details CBL Handling References for anti-CBL antibody (ABIN1105707) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-CBL Antibody Target Details CBL Application Details References for anti-CBL antibody (ABIN1105707) Images back to top
Format Liquid

References for anti-CBL antibody (ABIN1105707)

Product Details anti-CBL Antibody Target Details CBL Application Details Handling Images back to top
Background publications

Sproul, Xu, Wilhelm, Gire, Greene: "Cbl negatively regulates JNK activation and cell death." in: Cell research, Vol. 19, Issue 8, pp. 950-61, 2009

Loh, Sakai, Flotho, Kang, Fliegauf, Archambeault, Mullighan, Chen, Bergstraesser, Bueso-Ramos, Emanuel, Hasle, Issa, van den Heuvel-Eibrink, Locatelli, Stary, Trebo, Wlodarski, Zecca, Shannon et al.: "Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. ..." in: Blood, Vol. 114, Issue 9, pp. 1859-63, 2009

Sanada, Suzuki, Shih, Otsu, Kato, Yamazaki, Tamura, Honda, Sakata-Yanagimoto, Kumano, Oda, Yamagata, Takita, Gotoh, Nakazaki, Kawamata, Onodera, Nobuyoshi, Hayashi, Harada, Kurokawa, Chiba, Mori et al.: "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. ..." in: Nature, Vol. 460, Issue 7257, pp. 904-8, 2009

Images

Product Details anti-CBL Antibody Target Details CBL Application Details Handling References for anti-CBL antibody (ABIN1105707) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody
Immunohistochemistry (IHC) image for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 2)
Flow Cytometry (FACS) image for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 3)
Immunofluorescence (IF) image for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 4)
Western Blotting (WB) image for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 5)
Western Blotting (WB) image for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 6)
ELISA image for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 7)