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General |
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Antigen | CD247 Molecule (CD247) Antibodies |
Reactivity | Human, Mouse (Murine) Alternatives |
Host | Hamster Alternatives |
Clonality (Clone) | |
Conjugate | This CD247 antibody is un-conjugated Alternatives |
Application |
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
Alternatives
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Supplier | Log in to see |
Product Details anti-CD247 AntibodyTarget Details CD247 Application Details Handling Images |
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Specificity | This antibody detects the zeta subunit of the T cell receptor (TCR). |
Purification | Protein G Affinity Chromatography. |
Clone | H146-968 |
Isotype | IgG |
Target Details CD247Product Details anti-CD247 Antibody Application Details Handling Images back to top |
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Antigen | |
Alternative Name | CD247 / CD3Z (CD247 Antibody Abstract) |
Background | The TCR complex consists of a ligand specific alpha/beta heterodimer non-covalently associated with five invariant chains including the CD3 gamma, delta, eta and zeta subunits. This complex regulates assembly and expression of the receptor and is thought to be responsible for transmembrane transduction of signals after binding to TCRαβ. Studies have suggested that the CD3z subunit (also know as CD247) plays an important role in two distinct cellular compartments. In the cytoplasm, it may function to regulate Ag receptor expression and in the plasma membrane it may be required for optimal signaling by the physiologic ligand Ag/MHC. The CD3z subunit is also associated with the CD16 IgG Fc receptor on NK cells.Synonyms: CD3 zeta chain, T-cell receptor T3 zeta chain, T-cell surface glycoprotein CD3 zeta chain, T3Z, TCRZ |
Gene ID | 12503 |
Pathways | TCR Signaling, CXCR4-mediated Signaling Events |
Application DetailsProduct Details anti-CD247 Antibody Target Details CD247 Handling Images back to top |
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Application Notes | Optimal working dilution should be determined by the investigator. |
Restrictions | For Research Use only |
HandlingProduct Details anti-CD247 Antibody Target Details CD247 Application Details Images back to top |
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Concentration | 1.0 mg/mL |
Buffer | PBS containing 0.02 % Sodium Azide as preservative. |
Preservative | Sodium azide |
Precaution of Use | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
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Supplier Images |