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These preliminary results suggest that patients undergoing liver or kidney transplant can be stratified at high risk of EAR according to their CD28 molecule expression on peripheral CD4 (show CD4 Proteins)(+) T lymphocytes.
The aim of this case-control study is to investigate whether GABRG2 (show GABRG2 Proteins) polymorphisms contribute to susceptibility for Febrile seizure and epilepsy in pooled data of three cohorts, from Malaysia (composed of Malay, Chinese, and Indian), Hong Kong, and Korea.
The rs3116496 (T>C), rs3181098 (G>A) and rs3181100 (G>C) of CD28 were, respectively, found to be correlated with incremental susceptibility to recurrent spontaneous abortion under the allelic model.
Study utilized targeted next-gen sequencing to identify a novel splicing variation (NM_198903.2:c.1249-1G > T) in the GABRG2 (show GABRG2 Proteins) gene of a febrile seizure (FS) patient. The potential association of ten selected genetic polymorphisms in IL1RN (show IL1RN Proteins) (86-bp VNTR), IL10 (show IL10 Proteins) (rs1900872), PTGS2 (show PTGS2 Proteins) (8 SNPs, rs689465, rs689466, rs20417, rs13306038, rs201931599, rs689470, rs4648306 and rs4648308) with FS was also examined.
Coexpression of CD200R-CD28 enhances function in WT1 (show CD200R1 Proteins)-specific T-cell receptor - transduced (show CD8A Proteins) human primary T cells.
the upregulation of others syncytial molecules, including LAG3 (show LAG3 Proteins), CTLA4 (show CTLA4 Proteins), CD28 and CD3 (show CD3 Proteins), assisting the formation of syncytia with APC (show APC Proteins) cells.
our data provide the first evidence of a strict link between the absence of CD28 and the expression of perforin (show PRF1 Proteins), which is likewise enhanced by the expression of NKG2D (show KLRK1 Proteins), within selected CD4 (show CD4 Proteins)(+) T cells from cervical cancer patients.
Mutation of the basic clusters in the CD28 cytoplasmic domain reduced the recruitment to the CD28-Lck (show LCK Proteins) complex of protein kinase (show CDK7 Proteins) Ctheta; (PKCtheta (show PRKCQ Proteins);), which serves as a key effector kinase in the CD28 signaling pathway.
This study identified a missense de novo mutation in the GABAA (show GABRg1 Proteins) receptor gamma2 subunit, P302L, in a patient with Dravet syndrome. The mutation has a novel pathogenic mechanism to cause defects in the conductance and gating of GABAA (show GABRg1 Proteins) receptors, which results in hyperexcitability and contributes to the pathogenesis of the genetic epilepsy Dravet syndrome.
The mutant CD28 isoforms could accelerate tumor cell growth.
This work unravels a new regulatory mechanism for CD28 signaling that involves dynamic interplay between acidic phospholipids and Ca2 (show CA2 Proteins)+ to set the local electrostatic environment.
CD28 signaling is required for follicular Treg cell differentiation. Treg-specific deletion of CD28 caused a reduction in TFR (show TFRC Proteins) cell numbers and function, which resulted in increased germinal center B cells and Ab production. CD28-deficient TFR (show TFRC Proteins) cells showed a diminished suppressive capacity.
In adoptive therapy of disseminated leukemia, CD200R (show CD200R1 Proteins)-CD28-transduced leukemia-specific CD8 (show CD8A Proteins) T cells eradicated otherwise lethal disease more efficiently than wild-type cells and bypassed the requirement for interleukin-2 (show IL2 Proteins) administration to sustain in vivo activity.
Study shows that CD28 ligation during priming endows T cells with mitochondrial capacity that is important for future T cell responses. We speculate that CD28 temporarily restricts TXNIP (show TXNIP Proteins) and miR33 expression, and this leads to a transient induction of Cpt1a (show CPT1A Proteins) and fatty acid oxidation, which are marked by characteristic changes in mitochondria shape and structure.
findings revealed a dual mechanism of monocyte and neutrophil recruitment by T cells relying on overlapping and nonoverlapping roles for the noninducible costimulatory receptor CD28 and the inflammatory cytokine TNF (show TNF Proteins)
results are consistent with a complex pathway in which CD28 is the primary driver of Treg proliferation and CTLA-4 (show CTLA4 Proteins) functions as the main brake but is also dependent on TCR signals and interactions with CD80 (show CD80 Proteins)/CD86 (show CD86 Proteins).
data suggest that mPEG PV1 (show PLVAP Proteins)-Fab (show FANCB Proteins)' acts mainly on IFN-gamma (show IFNG Proteins)-producing CD4 (show CD4 Proteins)+ T cells and emphasize that this specific CD28 blockade strategy is a potential specific and alternative tool for the treatment of autoimmune disorders in the eye.
the scaffolding role of RLTPR predominates during CD28 co-stimulation and underpins the similar function of RLTPR in human and mouse T cells.
BAFF (show TNFSF13B Proteins) upregulates CD28/B7 and CD40 (show CD40 Proteins)/CD154 (show CD40LG Proteins) expression, and promotes the interactions between T and B cells in a BAFF-R (show TNFRSF13C Proteins)-dependent manner
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, T-cell-specific surface glycoprotein CD28
, CD28 antigen (Tp44)
, T-cell-specific surface glycoprotein CD28 homolog
, T-cell costimulatory molecule CD28
, cell surface protein
, costimulatory molecule B7 receptor CD28
, antigen CD28
, T-cell specific surface glycoprotein CD28
, CD28 precursor protein
, T-cell-specific surface glycoprotein CD28-like protein
, CD28 molecule L homeolog