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PCR and transcriptome analysis suggest that the genes CD3D and PKRCQ together can be used as a model for differentiating between B-cell and T-cell acute lymphoblastic leukemia.
we demonstrate that the incorporation of a 2A self-processing peptide derived from foot-and-mouth disease virus conveying co-translational cleavage into a two-chain anti-CD3 (show CD3 Proteins) x anti-CEA (show CEACAM5 Proteins) diabody gene enables near-equimolar expression of diabody chains 1 and 2, and thus increases the final amount of assembled diabody.
A FOXP3 (show FOXP3 Proteins)(+)CD3 (show CD3 Proteins)(+)CD56 (show NCAM1 Proteins)(+)-expressed T-cell population with immunosuppressive function and reduced patient survival has been identified in cancer tissues of human hepatocellular carcinoma.
The docking site for CD3 (show CD3 Proteins) subunits on the T Cell receptor beta chain has been identified by solution NMR.
analysis of the molecular organization of the TCR-CD3 (show CD3 Proteins) complex
Two cases of SCID (show PRKDC Proteins) with CD3delta gene mutation in Mexican Mennonite infants are described.
The surface TCR expression of primary alphabeta and gammadelta T cells from healthy donors carrying a single null or leaky mutation in CD3G (gamma+/-) or CD3D (delta+/-, delta+/leaky) with that of normal controls, were compared.
Altered expression of the TCR signaling related genes CD3 (show CD3 Proteins) and FcepsilonRIgamma in patients with aplastic anemia.
A transgenic T cell receptor gammadelta-low expressing subset of T cells accumulates in mouse ear keratinocytes after IL-23 (show IL23A Proteins) injections.
report 2 unrelated cases of SCID (show PRKDC Proteins) with a selective block in alphabeta but not in gammadelta T cell development, associated with a new splicing mutation in the CD3D gene
Mutation of Cd3d not only impairs the proper development of amacrine cells expressing Cd3d but also those not expressing Cd3d . In contrast to effects of Major histocompatibility complex and its receptor, PirB (show LILRB3 Proteins), on other neurons, mutation of Cd3d has no effect on retinal ganglion cells death and starburst amacrine cells degeneration after optic nerve crush.
CD3 (show CD3E Proteins)/CD28 (show CD28 Proteins)-inducible MNSFbeta (show FAU Proteins)-Bcl-G complex may be involved in the regulation of T cell function and survival.
Polymorphisms of the CD3delta ectodomain exist in mice,some of which lead to amino acid substitutions which cause structural changes and affect anti-CD3 (show CD3E Proteins) antibody binding.
mouse CD3delta has a T-cell specific expression pattern
there is one molecule each of CD3delta and CD3gamma in the surface TCR/CD3 (show CD3E Proteins) complex
A human CD3 (show CD3E Proteins) transgene that encodes full length CD3delta and a truncated but functional form of CD3epsilon (show CD3E Proteins) restored the defective preTCR function in not only CD3epsilon (show CD3E Proteins)- but CD3gamma- and CD3gammadelta-deficient mice as well.
CD3delta and CD3gamma play a different role in humans and mice in pre-TCR and TCR function during alphabeta T-cell development
CD3delta transgene rescues gammadelta T cell development in mice lacking both mouse CD3delta and CD3gamma.
In cystic teratomas of the ovary, CD1 (show CD1A Proteins)-positive Langerhans cells appeared to cross the basal membrane and penetrate the subepidermal tissue, and they were associated there with T-cell line lymphocytes (CD3 (show CD3 Proteins) positive).
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.
CD3 antigen, delta subunit
, CD3 delta
, CD3d antigen, delta polypeptide (TiT3 complex)
, OKT3, delta chain
, T-cell receptor T3 delta chain
, T-cell surface glycoprotein CD3 delta chain
, CD3 delta chain
, antigen CD3D, delta polypeptide (TiT3 complex)
, CD3d molecule, delta (CD3-TCR complex)
, CD3 antigen delta polypeptide
, CD3 molecule delta polypeptide
, CD3 antigen delta chain
, CD3 antigen, delta polypeptide
, TcR CD3 delta-chain