- TCR Signaling
- anti-CD4 Antibodies
- anti-Ferret CD4 antibody for Flow Cytometry
We are preparing the requested document. Please wait, this may take a while...!
There was a problem generating the requested document, please try again.
Similar anti-CD4 Antibodies
|Antigen||CD4 Molecule (CD4) Antibodies|
|Epitope||AA 1-401 Alternatives|
|Conjugate||This CD4 antibody is conjugated to FITC Alternatives|
Flow Cytometry (FACS)
|Supplier||Log in to see|
Product Details anti-CD4 AntibodyTarget Details CD4 Application Details Handling Images
No cross-reactivity in ELISA with
|No Cross-Reactivity||Human, Mouse (Murine)|
|Characteristics||This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Ferret CD4 (rF CD4, ABIN2008790 ABS50090.1, Met 1-Leu 401, and conjugated with FITC under optimum conditions, the unreacted FITC was removed.|
|Immunogen||Recombinant Ferret CD4 protein (ABIN2008790)|
|Plasmids, Primers & others|
Target Details CD4Product Details anti-CD4 Antibody Application Details Handling Images back to top
|Alternative Name||CD4 (CD4 Antibody Abstract)|
|Background||T-cell surface glycoprotein CD4, also known as T-cell surface antigen T4/Leu-3, is a single- pass type I membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoproteinexpressed on the surface of T helper cells, regulatory T cells,monocytes, macrophages, anddendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 before being named CD4 in 1984. CD4 is aco-receptorthat assists theT cell receptor (TCR) to activate its T cell following an interaction with anantigen presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR. CD4 interacts directly withMHC class II molecules on the surface of the antigen presenting cell via itsextracellulardomain. CD4 is a primary receptor used byHIV-1to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.|
|Pathways||TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events|
Application DetailsProduct Details anti-CD4 Antibody Target Details CD4 Handling Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD4 Antibody Target Details CD4 Application Details Images back to top
|Buffer||Aqueous solution containing 0.5 % BSA and 0.1 % sodium azide|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal|
This antibody is stable for 12 months from date of receipt when stored at 2°C-8°C. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
|Expiry Date||12 months|
ImagesProduct Details anti-CD4 Antibody Target Details CD4 Application Details Handling back to top
anti-CD4 Molecule (CD4) (AA 1-401) antibody (FITC)