anti-Human CD4 antibody for Blocking Reagent

Recommended CD4 Antibody (supplied by: Log in to see )

Antigen
CD4 Molecule (CD4) Antibodies
  • cd4
  • L3T4
  • Ly-4
  • CD4mut
  • W3/25
  • p55
  • CD4 molecule
  • carcinoembryonic antigen-related cell adhesion molecule 5
  • T-cell surface glycoprotein CD4
  • CD4 antigen
  • Cd4 molecule
  • CD4
  • LOC100125525
  • cd4
  • Cd4
Reactivity
Chimpanzee, Human
1271
584
237
71
61
41
36
30
27
26
25
25
22
21
18
18
15
15
13
12
10
9
9
7
5
5
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Host
Rabbit
1348
525
302
13
4
2
1
1
Antibody Type
Recombinant Antibody
Clonality
Chimeric
Conjugate
This CD4 antibody is un-conjugated
253
223
158
133
44
41
39
32
32
32
29
25
24
21
16
16
16
15
15
15
15
15
15
13
10
10
9
8
8
8
8
7
7
6
5
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Surface Plasmon Resonance (SPR)
1658
544
462
299
286
275
217
165
94
73
54
39
30
26
21
19
18
14
14
11
11
9
6
6
5
4
4
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Options
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Catalog No. ABIN5668248
$ 345.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN5668247 BR ELISA FACS IHC SPR Human IgG4, lambda Log in to see CE9-1 (Clenoliximab) 0
1 ABIN206939 Inhibition BR FACS Func IP Neut Mouse IgG2a Log in to see MEM-115 0
1 ABIN2663436 BR CyTOF Dep FACS IHC PE Mouse IgG1 kappa Log in to see SK3 5
1 ABIN2662640 Act BR CMCD Dep FACS IF IP IHC WB PE Rat IgG2b kappa Log in to see A161A1 5
1 ABIN2739383 BR FACS ELISA Cy7,PE Mouse IgG1 Log in to see QS4120 0
1 ABIN206889 Inhibition BR FACS Func IP Neut Mouse IgG2a Log in to see MEM-115 0
1 ABIN5526280 BR ELISA FACS IHC SPR Mammalian Cells IgG4 lambda Log in to see CE9-1 0
1 ABIN1956005 BR FACS Biotin Mouse IgG2b Log in to see hCD4 0
1 ABIN1957238 BR FACS FITC Mouse IgG2b Log in to see hCD4 0
1 ABIN2663437 BR CyTOF Dep FACS IHC PE Mouse IgG1 kappa Log in to see SK3 5
1 ABIN2662641 Act BR CMCD Dep FACS IF IP IHC WB PE Rat IgG2b kappa Log in to see A161A1 5
1 ABIN234613 BR IHC (f) FACS ELISA WB Mouse IgG1 Log in to see 13B8-2 0

General

Antigen CD4 Molecule (CD4) Antibodies
Reactivity Chimpanzee, Human
(1271), (584), (237), (71), (61), (41), (36), (30), (27), (26), (25), (25), (22), (21), (18), (18), (15), (15), (13), (12), (10), (9), (9), (7), (5), (5), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host Rabbit
(1348), (525), (302), (13), (4), (2), (1), (1)
Clonality (Clone)
Chimeric   ( )
Conjugate This CD4 antibody is un-conjugated
(253), (223), (158), (133), (44), (41), (39), (32), (32), (32), (29), (25), (24), (21), (16), (16), (16), (15), (15), (15), (15), (15), (15), (13), (10), (10), (9), (8), (8), (8), (8), (7), (7), (6), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Surface Plasmon Resonance (SPR)
(1658), (544), (462), (299), (286), (275), (217), (165), (94), (73), (54), (39), (30), (26), (21), (19), (18), (14), (14), (11), (11), (9), (6), (6), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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Product Details anti-CD4 Antibody

Target Details CD4 Application Details Handling Images
Specificity The antibody binds to human CD4 with a Kd of 1.0 nM and an ED50 of 0.2 μg/mL.
Characteristics Rabbit IgG based on the original Human IgG4 (primatized)
Purification Purified antibody.
Purity > 98 % as determined by SDS-PAGE
Endotoxin Level Endotoxin is < 1.0 EU/mg as determined by the LAL method
Immunogen Domain 1 of human CD4.
Clone CE9-1 (Clenoliximab)
Isotype IgG, lambda
Plasmids, Primers & others

Target Details CD4

Product Details anti-CD4 Antibody Application Details Handling Images back to top
Antigen
Alternative Name CD4 (CD4 Antibody Abstract)
Background P55, T cell surface antign T4/Leu-3.
Pathways TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events

Application Details

Product Details anti-CD4 Antibody Target Details CD4 Handling Images back to top
Application Notes The antibody binds specifically to CD4, a molecule which is part of the immunolgobulin super-family, expressed on the surface of helper T cells. The CD4 Molecule acts as a co-receptor in the activation of T cells, aiding the interaction between the TCR and MHC II of the antigen-presenting cell. The antibody is classified as 'primatized', as the variable regions of the light and heavy chains are obtained from primates, while the lamda light chain and ?4 heavy chain constant domains are human. The antibody was engineered from the primatized IgG1 monoclonal antibody Keliximab by substituting two key residues. The role of the antibody as an immunosuppressor has been tested in vivo, by intravenous administration in chimpanzees and human volunteers. The antibody reached Phase II clinical trials with Biogen-Idec.
Comment

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 (primatized) format, for improved compatibility with existing reagents, assays and techniq

Restrictions For Research Use only

Handling

Product Details anti-CD4 Antibody Target Details CD4 Application Details Images back to top
Buffer PBS with 0.02 % Proclin 300.
Preservative ProClin
Precaution of Use This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Images

Product Details anti-CD4 Antibody Target Details CD4 Application Details Handling back to top
Supplier Images
Flow Cytometry (FACS) image for anti-CD4 Molecule (CD4) antibody (ABIN5668248) Flow-cytometry using the anti-CD4 research biosimilar antibody Clenoliximab (CE9.1, )...