anti-Human CD80 antibody for Enzyme Immunoassay

Recommended CD80 Antibody (supplied by: Log in to see )

Antigen
CD80 Antibodies
  • B7
  • B7-1
  • B7.1
  • BB1
  • CD28LG
  • CD28LG1
  • LAB7
  • B71
  • Cd28l
  • Ly-53
  • Ly53
  • MIC17
  • TSA1
  • CD80 molecule
  • Cd80 molecule
  • CD80 antigen
  • CD80
  • Cd80
Reactivity
Human
455
286
49
11
11
6
3
3
2
2
1
Host
Mouse
398
126
97
94
42
16
Clonality
Monoclonal
Conjugate
This CD80 antibody is un-conjugated
71
70
53
40
19
17
16
15
10
7
7
6
6
6
6
6
6
6
6
5
5
5
5
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
509
220
171
153
115
100
80
42
40
26
22
22
12
8
8
6
5
5
5
5
2
2
2
2
1
1
1
1
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Catalog No. ABIN1106582
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
4 ABIN615921 EIA WB Goat Internal Region Log in to see Polyclonal 1

General

Antigen CD80 Antibodies
Reactivity Human
(455), (286), (49), (11), (11), (6), (3), (3), (2), (2), (1)
Host Mouse
(398), (126), (97), (94), (42), (16)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD80 antibody is un-conjugated
(71), (70), (53), (40), (19), (17), (16), (15), (10), (7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (5), (5), (5), (5), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(509), (220), (171), (153), (115), (100), (80), (42), (40), (26), (22), (22), (12), (8), (8), (6), (5), (5), (5), (5), (2), (2), (2), (2), (1), (1), (1), (1)
Pubmed 2 references available
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Product Details anti-CD80 Antibody

Target Details CD80 Application Details Handling References for anti-CD80 antibody (ABIN1106582) Images
Specificity Recognizes CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Clone 2A2
Isotype IgG1
Plasmids, Primers & others

Target Details CD80

Product Details anti-CD80 Antibody Application Details Handling References for anti-CD80 antibody (ABIN1106582) Images back to top
Antigen
Alternative Name CD80 (CD80 Antibody Abstract)
Background The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions. In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation. "When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans. Osteoclasts cause minerals to be released from the bone, so that calcium is taken into the bloodstream to be used for other functions of the body. Osteoclast differentiation is inhibited by osteoprotegerin, Estrogen stimulates osteoprotegerin production.Synonyms: Activation B7-1 antigen, B7-1, B7.1, BB1, CD28LG, CD28LG1, CTLA-4 counter-receptor B7.1, LAB7, T-lymphocyte activation antigen CD80
Molecular Weight 55 kDa
Gene ID 941
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process

Application Details

Product Details anti-CD80 Antibody Target Details CD80 Handling References for anti-CD80 antibody (ABIN1106582) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-CD80 Antibody Target Details CD80 Application Details References for anti-CD80 antibody (ABIN1106582) Images back to top
Format Liquid

References for anti-CD80 antibody (ABIN1106582)

Product Details anti-CD80 Antibody Target Details CD80 Application Details Handling Images back to top
Background publications

Wang, Liu, Wu, Zhu, Wang, Xu: "Evaluation of CD86/CD28 and CD40/CD154 pathways in regulating monocyte-derived CD80 expression during their interaction with allogeneic endothelium." in: Transplantation proceedings, Vol. 40, Issue 8, pp. 2729-33, 2008

Stephan, Ponomarev, Brentjens, Chang, Dobrenkov, Heller, Sadelain: "T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection." in: Nature medicine, Vol. 13, Issue 12, pp. 1440-9, 2007

Images

Product Details anti-CD80 Antibody Target Details CD80 Application Details Handling References for anti-CD80 antibody (ABIN1106582) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-CD80 (CD80) antibody (ABIN1106582) anti-CD80 (CD80) antibody
Immunofluorescence (IF) image for anti-CD80 (CD80) antibody (ABIN1106582) anti-CD80 (CD80) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-CD80 (CD80) antibody (ABIN1106582) anti-CD80 (CD80) antibody (Image 3)