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Human Polyclonal DRB1 Primary Antibody for ICC, IF - ABIN4306272
Collins, Riascos, Kovalik, An, Krupa, Krupa, Hood, Conrads, Renton, Traynor, Bowser: The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients. in Acta neuropathologica 2012
a new member of RRM-type neural RNA-binding protein
The mechanism involved in the interaction of HSP60-Ass conjugate with HLA-DR-DRB allele considering the fact that Ass (1-42) is highly immunogenic in human and interactions evoked highly robust T-cell response through MHC class II binding predictions.
HLA-DRB1 and -DQB1 gene polymorphisms contribute to the development/protection of type 1 diabetes with/without autoimmune thyroiditis.
this study found that allele HLA-DRB1*12 showed a positive association with end-stage renal disease in Dalian Han population located in north of China
HLA-DRB1 (show HLA-DRB1 Antibodies)*04 was associated with increased risk for rheumatoid arthritis and ACPA (show PRTN3 Antibodies) positivity, while HLA-DRB1 (show HLA-DRB1 Antibodies)*07 was associated with reduced risk for RA and rheumatoid factor synthesis in Algerian patients.
This study suggests the involvement of rs6457617 locus as risk variant for susceptibility/severity to rheumatoid arthritis in Tunisian population. Secondly, it highlights the gene-gene interaction between HLA-DQB1 (show HLA-DQB1 Antibodies) and HLA-DRB1 (show HLA-DRB1 Antibodies).
This study showed that no association was observed between rs1800629 genotypes or HLA-DRB1 (show HLA-DRB1 Antibodies) alleles and mesial temporal lobe epilepsy with hippocampal sclerosis susceptibility.
Polymorphisms in the HLA-DRB1 (show HLA-DRB1 Antibodies)*03 gene are associated with viral load in Hepatitis B virus .
DRB1 (show RBM45 Antibodies)*15 alleles are the first strong risk factor associated to a chronic inflammatory demyelinating polyradiculoneuropathy subset
HLA-DRB1 (show HLA-DRB1 Antibodies) rs13192471 SNP plays a critical role in Rheumatoid arthritis (RA) susceptibility and severity in North-east Indian cases and has prognostic significance in RA.
We hypothesize that the protective role of DRB1 (show RBM45 Antibodies)*13:02 is due to its successful elimination of external antigens to which Gulf War veterans were exposed, antigens that otherwise would persist causing low-grade inflammation and possibly leading to autoimmunity.
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide\; exons 2 and 3 encode the two extracellular domains\; exon 4 encodes the transmembrane domain\; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
, HLA class II histocompatibility antigen, DR-1 beta chain
, MHC class II HLA-DR beta 1 chain
, MHC class II HLA-DR-beta cell surface glycoprotein
, MHC class II HLA-DRw10-beta
, MHC class II antigen
, human leucocyte antigen DRB1
, lymphocyte antigen DRB1
, RNA-binding motif protein 45
, RNA-binding protein 45
, developmentally regulated RNA-binding protein 1
, developmentally-regulated RNA-binding protein 1