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anti-Human HLA-A Antibodies:
anti-Mouse (Murine) HLA-A Antibodies:
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Human Monoclonal HLA-A Primary Antibody for CyTOF, FACS - ABIN4900774
Loubaki, Chabot, Bazin: Involvement of the TNF-α/TGF-β/IDO axis in IVIg-induced immune tolerance. in Cytokine 2015
Show all 4 Pubmed References
Human Monoclonal HLA-A Primary Antibody for FACS - ABIN4898561
Lawson, Ebetino, Mazur, Chantry, Paton-Hough, Evans, Lath, Tsoumpra, Lundy, Dobson, Quijano, Kwaasi, Dunford, Duan, Triffitt, Jeans, Russell: The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate). in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2018
These data suggest that HLA-A*02:07 might be a genetic risk factor for developing clarithromycin-related cutaneous adverse drug reactions in Han Chinese and serve as a useful biomarker for personalized medicine to prevent these adverse reactions
Allelic and haplotype diversity of HLA-A, HLA-B and HLA-DRB1 gene at high resolution in the Nanning Han population.
Results indicted that HLA-A*02 and HLA-DRB1 (show HLA-DRB1 Antibodies) (*0407, *15 and *1501) polymorphisms might increase the risk of aplastic anemia (AA), while HLA-DRB1 (show HLA-DRB1 Antibodies) (*0301, *04, *0406, *0802, *1301, *1302 and *14) were protective against AA.
The HLA-A*31:01 allele is associated with carbamazepine-DRESS syndrome in Tunisians.
HLA-A*31:01 and HLA-B*15:02 alleles confer susceptibility to carbamazepine-induced severe cutaneous adverse reactions.
Furthermore, the KIR3DS1 + HLA-Bw4, KIR3DS1 + HLA-Bw4 (Iso80) , and KIR3DS1 + HLA-A Bw4 genotypes were significantly more common in recovered individuals than both healthy control and patient groups.
The association of the HLA-A*24:02, HLA-B*39:01 and HLA-B*39:06 alleles with type 1 diabetes is restricted to specific HLA-DR/HLA-DQ haplotypes in Finns.
in the Iranian population, HLA-A*68 confers susceptibility to Graves' disease
this study shows a significant protective function for HLA-A*30 gene against chronic renal failure development in Yemeni patients
The authors concluded that in the Chinese population, HLA-A*02:01 and DRB1 (show RBM45 Antibodies)*11:01 might be associated with the host capacity to clear hepatitis C virus independent of IL28B (show IL28B Antibodies), which suggests that the innate and adaptive immune responses both play an important role in the control of hepatitis C virus.
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
HLA class I histocompatibility antigen, A-1 alpha chain
, MHC class I antigen HLA-A heavy chain
, antigen presenting molecule
, leukocyte antigen class I-A