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A total of 39 HLA-A, 66 HLA-B and 47 HLA-DRB1 (show HLA-DRB1 Proteins) alleles were identified.
results demonstrate that HIV-1 Nef's inferior ability to downregulate MHC-B compared to that of MHC-A is conserved across primate lentiviruses and suggest that this property influences antiviral cellular immune responses.
Data (from studies using TCR-F50/GIL (show AQP3 Proteins)/HLA-A2) suggest there are multiple solutions to recognizing identical peptide-MHC (show HLAE Proteins) ligand with sufficient affinity to elicit broad anti- influenza virus response protective against viral escape. (TCR-F50 = GIL (show AQP3 Proteins)-specific T-cell receptor, alpha-beta; HLA-A2 major histocompatibility complex class I A; GIL (show AQP3 Proteins) = immunodominant influenza A virus epitope from M1) [M1, matrix protein 1]
In the present study, the HLA-A*31:01 allele was identified as a risk allele of lamotrigine-induced severe cutaneous adverse reactions in Koreans
Three new HLA class I alleles, HLA-A*02:620, HLA-B*27:150 and HLA-B*07:05:01:02, were described in the Spanish Caucasoid population
Data suggest that KH1 (show KCNF1 Proteins) and HK2 (show HK2 Proteins) domains of MEX3C (show MEX3C Proteins) bind with high affinity to MRE10, a 10-mer (show MERTK Proteins) RNA (5prime-CAGAGUUUAG-3prime) containing an eight-nucleotide MEX3C (show MEX3C Proteins) recognition element motif (AGAGUUUA); 3prime-untranslated region of HLA-A2 mRNA contains such a high affinity binding site for KH domains of MEX3C (show MEX3C Proteins). (MEX3C (show MEX3C Proteins) = mex-3 (show MEX3D Proteins) RNA binding family member C; HLA-A2 = HLA class I (show MICA Proteins) histocompatibility antigen, A-2 alpha chain (show FCGRT Proteins))
this study shows that alpha3-deletion isoform of HLA-A11 plays role in the immune escape of HIV-1
Data suggest that personalized peptide vaccine (PPV (show PPP6C Proteins)) with these nine CTL epitope peptides exhibit a good safety profile and positive immunological responses in HLA-A11+ or -A33 (show GPA33 Proteins)+ cancer patients.
findings demonstrate that gliadins contain epitopes that elicit CD8 (show CD8A Proteins)+ T cell responses restricted by HLA class I (show MICA Proteins) A*0101 and B*0801 molecules
Data suggest that only a small fraction of HLA-A*02:01- (HA)-binding ESO peptides are immunogenic, namely those that have high peptide-binding strength and peptide/HA complex stability. This study involved comparison of in silico-predicted and observed cytotoxic T-lymphocyte recognition of tumor antigen epitopes in melanoma patients and transgenic/knockout mice. (ESO = tumor antigen NY-ESO-1 (show CTAG1B Proteins))
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
HLA class I histocompatibility antigen, A-1 alpha chain
, MHC class I antigen HLA-A heavy chain
, antigen presenting molecule
, leukocyte antigen class I-A