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General |
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Antigen | Interferon Regulatory Factor 4 (IRF4) Antibodies |
Epitope | N-Term Alternatives |
Reactivity | Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Zebrafish (Danio rerio) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This IRF4 antibody is un-conjugated Alternatives |
Application |
Immunohistochemistry (IHC), Western Blotting (WB)
Alternatives
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1 reference available |
Supplier | Log in to see |
Product Details anti-IRF4 AntibodyTarget Details IRF4 Application Details Handling References for anti-IRF4 antibody (ABIN2780428) Images |
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Blocking Peptide | Blocking peptide for this product available: ABIN978603 |
Sequence | MNLEGGGRGG EFGMSAVSCG NGKLRQWLID QIDSGKYPGL VWENEEKSIF |
Predicted Reactivity | Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 86% |
Characteristics | This is a rabbit polyclonal antibody against IRF4. It was validated on Western Blot and immunohistochemistry. |
Purification | Affinity Purified |
Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human IRF4 |
Target Details IRF4Product Details anti-IRF4 Antibody Application Details Handling References for anti-IRF4 antibody (ABIN2780428) Images back to top |
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Antigen | |
Alternative Name | IRF4 (IRF4 Antibody Abstract) |
Background |
IFN regulatory factor (IRF)-4 is a lymphoid/myeloid-restricted member of the IRF transcription factor family that plays an essential role in the homeostasis and function of mature lymphocytes. IRF-4 expression is tightly regulated in resting primary T cells and is transiently induced at the mRNA and protein levels after activation by Ag-mimetic stimuli such as TCR cross-linking or treatment with phorbol ester and calcium ionophore (PMA/ionomycin). Alias Symbols: LSIRF, MUM1, NF-EM5 Protein Interaction Partner: UBC, STAT6, BCL6, TOP1, IRAK1, PRRC2B, YTHDC2, VPS35, PEG10, TLK2, CARM1, IKBKAP, ETV7, BATF, HOXB13, PROX1, HOXC11, FKBP4, SPIB, PRDM1, MYD88, TRAF2, NFATC2, SPI1, Protein Size: 451 |
Molecular Weight | 52 kDa |
Gene ID | 3662 |
NCBI Accession | NM_002460, NP_002451 |
UniProt | Q15306 |
Pathways | Chromatin Binding |
Application DetailsProduct Details anti-IRF4 Antibody Target Details IRF4 Handling References for anti-IRF4 antibody (ABIN2780428) Images back to top |
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Application Notes | Optimal working dilutions should be determined experimentally by the investigator. |
Comment |
Antigen size: 451 AA |
Restrictions | For Research Use only |
HandlingProduct Details anti-IRF4 Antibody Target Details IRF4 Application Details References for anti-IRF4 antibody (ABIN2780428) Images back to top |
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Format | Liquid |
Concentration | Lot specific |
Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose. |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handling Advice | Avoid repeated freeze-thaw cycles. |
Storage | -20 °C |
Storage Comment | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
References for anti-IRF4 antibody (ABIN2780428)Product Details anti-IRF4 Antibody Target Details IRF4 Application Details Handling Images back to top |
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Background publications |
Lehtonen, Veckman, Nikula, Lahesmaa, Kinnunen, Matikainen, Julkunen: "Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 10, pp. 6570-9, 2005 |
ImagesProduct Details anti-IRF4 Antibody Target Details IRF4 Application Details Handling References for anti-IRF4 antibody (ABIN2780428) back to top |
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Supplier Images |