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Evidence for an essential role of Notch (show NOTCH1 Proteins) signaling in the development of chronic lymphocytic leukemia (CLL) and establish IRF4 as a critical regulator of Notch (show NOTCH1 Proteins) signaling during CLL development.
These results show that significantly increased levels of FOXO3 (show FOXO3 Proteins), IRF4, and xIAP (show XIAP Proteins) mRNA in Chinese HIV-1-infected patients.
Mechanistically, we found that BETi-mediated inhibition of cMYC (show MYC Proteins) correlates with the upregulation of miR (show MLXIP Proteins)-125b-5p and the downregulation of the cMYC (show MYC Proteins)/miR (show MLXIP Proteins)-125b-5p target gene IRF4, a transcriptional repressor of MICA (show MICA Proteins).
BCL7A (show BCL7A Proteins), BRWD3, and AUTS2 demonstrate significantly higher mutation frequencies among AA cases. These genes are all involved in translocations in B-cell malignancies. Moreover, we detected a significant difference in mutation frequency of TP53 (show TP53 Proteins) and IRF4 with frequencies higher among CA cases. Our study provides rationale for interrogating diverse tumor cohorts to best understand tumor genomics across populations.
IRF4 protects arteries against neointima formation by promoting the expression of KLF4 (show KLF4 Proteins) by directly binding to its promoter.
We propose that the Irf4 locus functions as the "reader" of TCR signal strength, and in turn, concentration-dependent activity of Irf4 "writes" T helper fate choice.
PU.1-induced apoptosis in myeloma cells is associated with IRF4 downregulation and subsequent IRF7 (show IRF7 Proteins) upregulation.
GM-CSF (show CSF2 Proteins) can mediate inflammation and pain by regulating IRF4-induced CCL17 (show CCL17 Proteins) production
expression of CARMA1 (show CARD11 Proteins) mRNA is likely associated with the expression of MUM1 and shows male predominance in diffuse large B cell lymphoma.
Data show that BCL-6 (show BCL6 Proteins) (64%) and MUM1 (45%) were expressed in patients with primary mediastinal large B-cell lymphoma.
IRF4 is highly induced in graft-infiltrating T cells and is required for heart transplant rejection.
The findings indicate that IRF4 functions as a central node in a TCR-responsive transcriptional circuit that establishes and sustains T cell exhaustion during chronic viral infection.
RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3 (show GATA3 Proteins), SATB1 (show SATB1 Proteins), and IRF4.
this study shows that epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells
Cell fate and metabolic state are linked by transcriptional regulators, such as IRF4 and FoxO1 (show FOXO1 Proteins), with dual roles in lineage and metabolic choice. Instructing some cells to utilize nutrients for anabolism and differentiation while other cells catabolically self-digest and self-renew may enable growth and repair in metazoa.
Here the authors show that concomitant loss of Tet2 and Tet3 in mice at early B cell stage blocked the pro- to pre-B cell transition in the bone marrow, decreased Irf4 expression and impaired the germline transcription and rearrangement of the Igkappa locus.
Data show that Fos-Related Antigen-2 (Fra-2 (show FOSL2 Proteins)) is a key upstream regulator of forkhead box O1 (Foxo1 (show FOXO1 Proteins)) and interferon regulatory factor 4 (Irf4) expression and influences proliferation and differentiation of B cells at multiple stages.
MTORC2 (show CRTC2 Proteins) operated in parallel with the IL-4Ralpha-Stat6 (show STAT6 Proteins) pathway.
IRF4a and IRF4b displayed a distinct tissue expression pattern, embryonic stages expression and inducible expression in vivo and in vitro, suggesting that IRF4 paralogues might play different roles in immune system.
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6\;14)(p25\;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
interferon regulatory factor 4
, Interferon regulatory factor 4
, lymphocyte-specific interferon regulatory factor
, multiple myeloma oncogene 1
, PU.1 interaction partner
, Sfpi1/PU.1 interaction partner
, transcriptional activator PIP
, PWWP domain-containing protein MUM1
, mutated melanoma-associated antigen 1