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The dimerization-dependent, cooperative binding of the growth factor receptor-bound protein 2 (show GRB2 Proteins) family to LAT (show ORC3 Proteins) may increase antigen receptor sensitivity by reducing signalosome formation at incompletely phosphorylated linker of activated T cells LAT (show ORC3 Proteins) molecules, thereby prioritizing the formation of complete signalosomes.
Nur77 (show NR4A1 Proteins) suppresses CD4 (show CD4 Proteins)(+) T cell proliferation and uncover a suppressive role for Irf4 (show IRF4 Proteins) in TH2 polarization; halving Irf4 (show IRF4 Proteins) gene-dosage leads to increases in GATA3 (show GATA3 Proteins)(+) and IL-4 (show IL4 Proteins)(+) cells.
LAT and phospholipase C-gamma dephosphorylation by SHP-1 inhibits natural killer cell cytototoxicity
Here we report that phosphotyrosine-mediated assembly of adaptor protein LAT networks yields two distinct kinetic species of the Ras activator SOS
Overexpression of LAT (show ORC3 Proteins) is associated with microcephaly.
LAT (show ORC3 Proteins) and SLP-76 (show LCP2 Proteins) are randomly dispersed throughout the clusters that form upon T cell receptor engagement.
this study shows that inherited LAT (show ORC3 Proteins) deficiency should be considered in patients with combined immunodeficiency with T-cell abnormalities
This is the first report of a LAT (show ORC3 Proteins)-related disease in humans, manifesting by a progressive combined immune deficiency with severe autoimmune disease.
Data show that LAT1 plays an important role in regulating the uptake of essential amino acids such as leucine into endometrial cancer cells. Increased ability of BCH (show CHN2 Proteins) compared to LAT1 shRNA at inhibiting Ishikawa spheroid area suggests that other LAT (show ORC3 Proteins) family members may also contribute to cell growth.
Data indicate that the T cell-specific adaptor protein (TSAd (show SH2D2A Proteins)) SH2 domain interacts with CD6 antigen (show CD6 Proteins) and linker for activation of T cells protein (LAT (show ORC3 Proteins)) phosphotyrosine (pTyr) peptides.
this study shows that the site-specific delivery of linker for activation of T cells (LAT) in asthmatic mouse model
IFT20 (show IFT20 Proteins) is required for the delivery of the intracellular pool of LAT to the immune synapse in naive primary T lymphocytes.
miR (show MLXIP Proteins)-155 regulates the delicate balance between PAK1 (show PAK1 Proteins)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.
provide evidence that CD28 (show CD28 Proteins) and the TCR complex regulate NF-kappaB (show NFKB1 Proteins) via different signaling modules of GRB-2 (show GRB2 Proteins)/VAV1 (show VAV1 Proteins) and LAT/ADAP (show APP Proteins) pathways respectively.
The result indicate that LAT-PLCg1 (show PLCG1 Proteins) interaction is important for controlling IL-6 (show IL6 Proteins) production by T cells and demonstrate a critical role of IL-6 (show IL6 Proteins) in the development of the lymphoproliferative syndrome.
low level of LAT-PLC-gamma1 (show PLCG1 Proteins) interaction was associated with Th2 polarized differentiation, and this may contribute to the etiology of asthma.
These results suggest that proteasome-mediated degradation is involved in hypophosphorylated LAT and PLCgamma1 (show PLCG1 Proteins) in Dow2-induced anergic T cells. The novel CD3 (show CD3E Proteins)-specific Ab, Dow2, may provide us with a unique tool for inducing immunosuppression
Sos1 (show SOS1 Proteins) has distinct roles in acting as a scaffold to oligomerize the adaptor protein LAT, and in guanine nucleotide exchange activity
this analysis identified 65 proteins not associated before with the Zap70 (show ZAP70 Proteins)-Lat-SLP-76 (show LCP2 Proteins) network and thus should provide cues for future functional experiments.
Data suggest that transmembrane adaptor protein LAT-PLCgamma1 (Phospholipase C gamma 1 (show PLCG1 Proteins)) signaling may function differently in various subsets of gammadelta T cells.
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
linker for activation of T cells
, 36 kDa phospho-tyrosine adapter protein
, 36 kDa phospho-tyrosine adaptor protein
, linker for activation of T cells, transmembrane adaptor
, linker for activation of T-cells family member 1
, linker protein