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Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity).
PI3-kinase regulatory subunit alpha
, PI3-kinase subunit p85-alpha
, PI3K regulatory subunit alpha
, phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
, phosphatidylinositol 3-kinase regulatory subunit alpha
, ptdIns-3-kinase regulatory subunit alpha
, ptdIns-3-kinase regulatory subunit p85-alpha