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Alk1 (show ACVRL1 Proteins) deletion leads to increased endothelial PI3K pathway activation that may be a novel target for the treatment of vascular lesions in hereditary haemorrhagic telangiectasia type 2.
A central role of PI3K in development of obesity and fatty liver disease, separating these effects from the role of PI3K in insulin (show INS Proteins) resistance and the resultant hyperglycemia.
Findings provide evidence that Pik3r1 downregulation promotes hyperglycaemia probably by impairing GLUT4 (show SLC2A4 Proteins)-facilitated glucose uptake.
TLR2 confers a pivotal role in allergic airway inflammation via regulating the PI3K/Akt (show AKT1 Proteins) signaling pathway-related autophagy in mice.
These data suggest that the antidepressant-like effects of VPA might depend on PI3K and mTOR (show FRAP1 Proteins) activation.
These findings highlight a hitherto unexplored and novel role for Cbl (show CBL Proteins) and PI3K in modulating the osteogenic response of periosteal cells during the early stages of fracture repair.
Data indicate alpha-P85 (show ECM1 Proteins) Subunit, PI-3K (p85alpha) as a positive regulator of epidermal growth factor receptor (EGFR (show EGFR Proteins)) expression and cell malignant transformation via nucleolin (show NCL Proteins)-dependent mechanism.
Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
insulin (show INS Proteins) and aPC (show APC Proteins) converge on a common spliced-X-box binding protein-1 (show XBP1 Proteins) (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.
Data demonstrated a novel role of Pik3r1 that was independent of the regulatory function of phosphoinositide 3-kinase in mediating the metabolic action of glucocorticoids. Glucocorticoids increased hormone sensitive lipase phosphorylation, but not Plin1 phosphorylation, in adipose tissue-specific Pik3r1-null (AKO) mice.
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity).
PI3-kinase regulatory subunit alpha
, PI3-kinase subunit p85-alpha
, PI3K regulatory subunit alpha
, phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
, phosphatidylinositol 3-kinase regulatory subunit alpha
, ptdIns-3-kinase regulatory subunit alpha
, ptdIns-3-kinase regulatory subunit p85-alpha