anti-PTEN Antibodies

Protein Summary

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT\\/PKB signaling pathway.

Alternative names and synonyms associated with PTEN

• phosphatase and tensin homolog (Pten) antibody
• phosphatase and tensin homolog (PTEN) antibody
• phosphatase and tensin homolog L homeolog (pten.L) antibody

• 10q23del antibody
• 2310035O07Rik antibody
• A130070J02Rik antibody
• AI463227 antibody
• B430203M17Rik antibody
• Show all synonym aliases
• BZS antibody
• CWS1 antibody
• DEC antibody
• GLM2 antibody
• MHAM antibody
• Mmac antibody
• MMAC1 antibody
• PTEN1 antibody
• PTENP1 antibody
• TEP1 antibody

Protein level used designations for PTEN

mutated in multiple advanced cancers 1 , phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN , phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN , protein tyrosine phosphatase and tensin-like protein , phosphatase and tensin homolog deleted on chromosome ten , phosphatase and tensin homolog (mutated in multiple advanced cancers 1) , MMAC1 phosphatase and tensin homolog deleted on chromosome 10 , phosphatase and tensin-like protein , homolog of human mutated in multiple advanced cancers , protein/lipid phosphatase Pten