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|Antigen||Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This RIPK2 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|2 references available|
|Supplier||Log in to see|
Product Details anti-RIPK2 AntibodyTarget Details RIPK2 Application Details Handling References for anti-RIPK2 antibody (ABIN360158) Images
|Specificity||This antibody reacts to RIP2 (RIIPK2).|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human RIPK2.|
Target Details RIPK2Product Details anti-RIPK2 Antibody Application Details Handling References for anti-RIPK2 antibody (ABIN360158) Images back to top
|Alternative Name||RIPK2 (RIPK2 Antibody Abstract)|
|Background||RIPK2 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.Synonyms: CARD-containing IL-1 beta ICE-kinase, CARDIAK, RICK, RIP-2, RIP-like-interacting CLARP kinase, RIP2, Receptor-interacting protein 2, Receptor-interacting serine/threonine-protein kinase 2|
|Research Area||Apoptosis/Necrosis, Signaling|
|Pathways||TCR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-RIPK2 Antibody Target Details RIPK2 Handling References for anti-RIPK2 antibody (ABIN360158) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-RIPK2 Antibody Target Details RIPK2 Application Details References for anti-RIPK2 antibody (ABIN360158) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-RIPK2 antibody (ABIN360158)Product Details anti-RIPK2 Antibody Target Details RIPK2 Application Details Handling Images back to top
Stehlik, Hayashi, Pio, Godzik, Reed: "CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways." in: The Journal of biological chemistry, Vol. 278, Issue 34, pp. 31941-9, 2003
Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003
ImagesProduct Details anti-RIPK2 Antibody Target Details RIPK2 Application Details Handling References for anti-RIPK2 antibody (ABIN360158) back to top