anti-Human ACD antibody for Immunohistochemistry

Recommended ACD Antibody (supplied by: Log in to see )

Antigen
Adrenocortical Dysplasia Homolog (Mouse) (ACD) Antibodies
  • PIP1
  • PTOP
  • TINT1
  • TPP1
  • ACD
  • ACD, shelterin complex subunit and telomerase recruitment factor
  • adrenocortical dysplasia
  • ACD
  • Acd
Epitope
AA 1-545
11
6
5
4
2
2
2
1
1
1
1
1
1
Reactivity
Human
76
28
23
4
4
4
4
1
Host
Mouse
54
22
7
Clonality
Monoclonal
Conjugate
This ACD antibody is un-conjugated
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
65
23
14
13
12
9
7
7
4
2
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Available images

Catalog No. ABIN395038
$ 461.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
8.85804 ABIN4348558 IHC IHC (p) Rabbit IgG Log in to see Polyclonal 0
8.85804 ABIN4277586 IHC WB Mouse IgG1 Log in to see 2B1 0
1 ABIN1496406 IHC IHC (p) WB Mouse IgG1 Log in to see 2B1 0
1 ABIN442140 IHC (p) IHC WB Rabbit IgG Center Log in to see Polyclonal 0
1 ABIN599297 ELISA IF IHC IHC (p) IP WB Mouse IgG1, kappa AA 1-545 Log in to see 1D8-1B6 0
1 ABIN4277585 ICC IF IHC IHC (p) Rabbit IgG Log in to see Polyclonal 0
1 ABIN6246330 IHC WB Mouse IgG1 Log in to see OTI2B1 0
1 ABIN2378782 IHC ELISA WB Mouse IgG AA 195-305 Log in to see 9G454 0
1 ABIN2194428 IF IP IHC ELISA WB Mouse IgG1 kappa AA 1-544 Log in to see 1D8-1B6 0
1 ABIN2715648 IHC WB Mouse IgG1 Log in to see OTI2B1 0

General

Antigen Adrenocortical Dysplasia Homolog (Mouse) (ACD) Antibodies
Epitope AA 1-545
(11), (6), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity Human
(76), (28), (23), (4), (4), (4), (4), (1)
Host Mouse
(54), (22), (7)
Clonality (Clone)
Monoclonal   ( )
Conjugate This ACD antibody is un-conjugated
(3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
(65), (23), (14), (13), (12), (9), (7), (7), (4), (2)
Pubmed 5 references available
Supplier Log in to see

Product Details anti-ACD Antibody

Target Details ACD Application Details Handling References for anti-ACD antibody (ABIN395038) Images
Specificity ACD (AAH16904, 1 a.a. ~ 545 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Cross-Reactivity (Details) Human: ~~ Positive
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Immunogen

Antigen Type: Recombinant Protein

Target/Specificity: ACD (AAH16904, 1 a.a. ~ 544 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone S1
Isotype IgG1 kappa
Plasmids, Primers & others

Target Details ACD

Product Details anti-ACD Antibody Application Details Handling References for anti-ACD antibody (ABIN395038) Images back to top
Antigen
Alternative Name ACD (ACD Antibody Abstract)
Background

Other Names: Adrenocortical dysplasia protein homolog, POT1 and TIN2-interacting protein, ACD, PIP1, PTOP, TINT1, TPP1

Gene Description: adrenocortical dysplasia homolog (mouse)

Gene Summary: This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq

Molecular Weight 57758 DA
Gene ID 65057
NCBI Accession NP_001075955, NP_001075956, NP_075065
UniProt Q96AP0
Pathways Telomere Maintenance

Application Details

Product Details anti-ACD Antibody Target Details ACD Handling References for anti-ACD antibody (ABIN395038) Images back to top
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.

Restrictions For Research Use only

Handling

Product Details anti-ACD Antibody Target Details ACD Application Details References for anti-ACD antibody (ABIN395038) Images back to top
Concentration 0.5 mg/mL
Buffer Clear, colorless solution in phosphate buffered saline,  pH 7.2 .
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months

References for anti-ACD antibody (ABIN395038)

Product Details anti-ACD Antibody Target Details ACD Application Details Handling Images back to top
Background publications

Abreu, Aritonovska, Reichenbach, Cristofari, Culp, Terns, Lingner, Terns: "TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo." in: Molecular and cellular biology, Vol. 30, Issue 12, pp. 2971-82, 2010

Varadi, Brendle, Brandt, Johansson, Enquist, Henriksson, Svenson, Tavelin, Roos, Hemminki, Lenner, Försti: "Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis." in: European journal of cancer (Oxford, England : 1990), Vol. 45, Issue 17, pp. 3008-16, 2009

Wan, Qin, Songyang, Liu: "OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation." in: The Journal of biological chemistry, Vol. 284, Issue 39, pp. 26725-31, 2009

Tang, Zhou, Lei, Yu, Xie, Zhou, Liu: "Increased expression of telomere-related proteins correlates with resistance to radiation in human laryngeal cancer cell lines." in: Oncology reports, Vol. 21, Issue 6, pp. 1505-9, 2009

Else, Theisen, Wu, Hutz, Keegan, Hammer, Ferguson: "Tpp1/Acd maintains genomic stability through a complex role in telomere protection." in: Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, Vol. 15, Issue 8, pp. 1001-13, 2008

Images

Product Details anti-ACD Antibody Target Details ACD Application Details Handling References for anti-ACD antibody (ABIN395038) back to top
Supplier Images
Western Blotting (WB) image for anti-Adrenocortical Dysplasia Homolog (Mouse) (ACD) (AA 1-545) antibody (ABIN395038) Immunofluorescence of monoclonal antibody to ACD on HeLa cell (antibody concentration...
Immunohistochemistry (IHC) image for anti-Adrenocortical Dysplasia Homolog (Mouse) (ACD) (AA 1-545) antibody (ABIN395038) anti-Adrenocortical Dysplasia Homolog (Mouse) (ACD) (AA 1-545) antibody (Image 2)
Western Blotting (WB) image for anti-Adrenocortical Dysplasia Homolog (Mouse) (ACD) (AA 1-545) antibody (ABIN395038) Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunoge...
Immunohistochemistry (IHC) image for anti-Adrenocortical Dysplasia Homolog (Mouse) (ACD) (AA 1-545) antibody (ABIN395038) Immunoperoxidase of monoclonal antibody to ACD on formalin-fixed paraffin-embedded hu...
Immunofluorescence (IF) image for anti-Adrenocortical Dysplasia Homolog (Mouse) (ACD) (AA 1-545) antibody (ABIN395038) Immunofluorescence of monoclonal antibody to ACD on HeLa cell. [antibody concentratio...
Immunoprecipitation (IP) image for anti-Adrenocortical Dysplasia Homolog (Mouse) (ACD) (AA 1-545) antibody (ABIN395038) Immunoprecipitation of ACD transfected lysate using anti-ACD monoclonal antibody and ...
ELISA image for anti-Adrenocortical Dysplasia Homolog (Mouse) (ACD) (AA 1-545) antibody (ABIN395038) Detection limit for recombinant GST tagged ACD is 0.3 ng/ml as a capture antibody.