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DKC1 Proteins

(Dyskeratosis Congenita 1, Dyskerin (DKC1))
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases. Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013].
DKC1 Protein (AA 321-420) (GST tag) DKC1 Protein (AA 321-420) (GST tag) DKC1 Protein (AA 321-420) (GST tag) (ABIN1351642)

DKC1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP

DKC1 Protein (AA 1-514) (GST tag) DKC1 Protein (AA 1-514) (GST tag) DKC1 Protein (AA 1-514) (GST tag) (ABIN1351641)

DKC1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP

DKC1 Protein (AA 2-514) (His tag) DKC1 Protein (AA 2-514) (His tag) DKC1 Protein (AA 2-514) (His tag) (ABIN3092145)

Crystallography grade DKC1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

DKC1 Proteins by Grade

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DKC1 Proteins by Origin

Find DKC1 Proteins for a variety of species such as anti-Human DKC1, anti-Mouse DKC1, anti-Rat DKC1. The species listed below are among those available. Click on a link to go to the corresponding products.

DKC1 Proteins by Source

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DKC1 Proteins by Protein Type

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DKC1 Proteins by Application

Find DKC1 Proteins validated for a specific application such as ELISA, WB, SDS, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular DKC1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351642
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351641
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3092145
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3137237
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7418884
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7418887
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7418890
Quantity 100 μg
Datasheet Datasheet
Reactivity Schizosaccharomyces pombe
Source Yeast
Validations
Cat. No. ABIN1510156
Quantity 1 mg
Datasheet Datasheet
Reactivity Saccharomyces cerevisiae
Source Yeast
Validations
Cat. No. ABIN1477946
Quantity 1 mg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1474242
Quantity 1 mg
Datasheet Datasheet

Aliases for DKC1 Proteins

dyskerin pseudouridine synthase 1 (DKC1) Proteins
microRNA 664b (MIR664B) Proteins
dyskeratosis congenita 1, dyskerin (dkc1) Proteins
dyskeratosis congenita 1, dyskerin L homeolog (dkc1.L) Proteins
dyskeratosis congenita 1, dyskerin (Dkc1) Proteins
dyskerin pseudouridine synthase 1 (Dkc1) Proteins
homologue of NAP57 (NAP57) Proteins
AtCBF5 Proteins
AtNAP57 Proteins
BC068171 Proteins
CBF5 Proteins
cbf5 Proteins
DKC Proteins
dkc Proteins
DKC1 Proteins
DKCX Proteins
dyskerin Proteins
fv62a07 Proteins
homologue of NAP57 Proteins
NAP57 Proteins
nap57 Proteins
Nap57 Proteins
NOLA4 Proteins
nola4 Proteins
wu:fa28f10 Proteins
wu:fc87a02 Proteins
wu:fi24a05 Proteins
wu:fv62a07 Proteins
XAP101 Proteins
xap101 Proteins
zgc:110395 Proteins
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