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Authors showed that RFC5 expression is positively correlated with FoxM1 expression in human glioma cells and FoxM1 is able to transcriptionally activate RFC expression by interaction with the RFC5 promoter.
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9.
replication factor C subunit 5
, replication factor C subunit RFC5
, A1 36 kDa subunit
, RF-C 36 kDa subunit
, activator 1 36 kDa subunit
, activator 1 subunit 5
, replication factor C 36 kDa subunit
, replication factor C 5
, replication factor C, 36 kDa
, RFC, 36.5 kD subunit
, replication factor C, 36-kDa subunit