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Human Polyclonal RPA1 Primary Antibody for IHC (p), IHC - ABIN151627
Thangavel, Mendoza-Maldonado, Tissino, Sidorova, Yin, Wang, Monnat, Falaschi, Vindigni: Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation. in Molecular and cellular biology 2010
Show all 6 Pubmed References
Yeast (Saccharomyces cerevisiae) Polyclonal RPA1 Primary Antibody for ChIP, IP - ABIN190714
Chen, Lisby, Symington: RPA coordinates DNA end resection and prevents formation of DNA hairpins. in Molecular cell 2013
Show all 5 Pubmed References
Human Monoclonal RPA1 Primary Antibody for ICC, FACS - ABIN969564
Sowd, Wang, Pretto, Chazin, Opresko: Replication protein A stimulates the Werner syndrome protein branch migration activity. in The Journal of biological chemistry 2009
Human Polyclonal RPA1 Primary Antibody for WB - ABIN658336
Smith, Krumpelbeck, Jegga, Prell, Matrka, Kappes, Greis, Ali, Meetei, Wells: The nuclear DEK interactome supports multi-functionality. in Proteins 2018
Data show that short ssDNA traverses the nuclear membrane, but is drawn into the nucleus by binding to the DNA replication and repair factors replication protein A (RPA) and Rad51 (show RAD51 Antibodies) recombinase (show RAG1 Antibodies) (Rad51 (show RAD51 Antibodies)).
These new findings supports the existence of a functional PrimPol/RPA association that allows repriming at the exposed ssDNA regions formed in the leading strand upon replicase stalling.
regulatory pathway based on casein kinase 2-G9a-RPA permits homologous recombination in cancer cells
RPA1 serves as an oncogene (show RAB1A Antibodies) during gastrointestinal cancers progression
RPA1 is significantly up-regulated in hepatocellular carcinoma and correlates with poor prognosis. RPA1 influences cell cycle through CDK4/Cyclin-D pathway.
PCAF (show KAT2B Antibodies)/GCN5 (show KAT2A Antibodies)-mediated lysine 163 acetylation of RPA1 is crucial for nucleotide excision repair.
the acetylation status of RPA1 played a crucial role in repair of DNA damage via nucleotide excision repair.
data obtained allow us to suggest that XPA can be involved in the post-incision NER stages via its interaction with RPA
The results suggest that RPA phosphorylation enhances the recruitment of PRP19 to RPA-ssDNA and stimulates RPA ubiquitylation through a process requiring both PRP19 and RFWD3, thereby triggering a phosphorylation-ubiquitylation circuitry that promotes ATR activation and homologous recombination.
RPA recruits HIRA to promoters and enhancers and regulates deposition of newly synthesized H3.3 to these regulatory elements for gene regulation.
The recovery of abnormal phenotypes of mutant Ataxin-1 (show ATXN1 Antibodies) knock-in (Atxn1 (show ATXN1 Antibodies)-KI) mice in the dendrite and spine morphology of Purkinje cells by AAV vector-mediated expression of RpA1 was reported.
The authors establish that a second Dna2-Rpa interaction is mutually exclusive with Rpa-DNA interactions and mediates the displacement of Rpa from ssDNA.
LT prevents recruitment of RPA to nuclear foci after DNA damage. This leads to failure to recruit repair proteins such as Rad51 (show RAD51 Antibodies) or Rad9 (show RAD9A Antibodies), explaining why LT prevents repair of double strand DNA breaks by homologous recombination.
Most RPA recruitment during class switch recombination represents salvage of unrepaired breaks by homology-based pathways during the S-G2 (show STRN3 Antibodies)/M phase of the cell cycle.
POT1a (show POT1 Antibodies) degradation resulted in rapid and reversible activation of the ATR (show ATR Antibodies) pathway in G1 and S/G2 (show STRN3 Antibodies).
Rpa1(L230P) missense mutation significantly alters the tumor phenotype and spectrum of Trp53 (show TP53 Antibodies) mutant mice by modifying the genetic mechanisms underlying tumorigenesis.
both TNFR-p55 (show TNFRSF1A Antibodies) and TNFR (show TNFRSF1A Antibodies)-p75 (show NGFR Antibodies) appear to be of minimal importance for modulation of Fas (show FAS Antibodies)-mediated apoptosis and associated A1 protein expression despite normal Fas (show FAS Antibodies)/TNFR-p55 (show TNFRSF1A Antibodies) and increased TNFR (show TNFRSF1A Antibodies)-p75 (show NGFR Antibodies) expression in neutrophils
Rpa1 functions in DNA metabolism are essential for the maintenance of chromosomal stability and tumor suppression.
hyperphosphorylation may play a role in modulating cellular pathways by altering the DNA binding domain-mediated RPA-DNA and RPA-protein interactions, hypothetically via the interaction of hyperphosphorylated RPA32N with DBD-B
These results demonstrate that neither RPA hyper-phosphorylation nor H2AX are required for the formation in RPA intra-nuclear foci in response to DNA damage/replicational stress.
This study found that the N-terminus of the RPA large subunit interacts with both WRN and DNA2 (show DNA2 Antibodies) and is essential for stimulating WRN's 3'->5' helicase (show DNA2 Antibodies) activity and DNA2 (show DNA2 Antibodies)'s 5'->3' ss-DNA exonuclease (show EXO1 Antibodies) activity.
The results provide strong biochemical evidence to link RPA to a specific DSB repair pathway and reveal a novel function of RPA in the generation of 3' ss-DNA for homology-dependent DSB repair.
Replication protein A (show GPR153 Antibodies) accumulated increasingly on replication-arrested chromatin.
RPA1 subunit may directly recognize and bind to the 5-formyluracil on the single-stranded DNA.
loss-of-function alleles indicate that RPA is required to prevent neuroepithelial cells from differentiating into medulla neuroblasts
Data show that the basic cleft of the RPA70 N-terminal OB-fold domain binds multiple checkpoint proteins, including RAD9, to promote ATR signaling.
Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair\; it does not support chromosomal DNA replication and cell cycle progression through S- phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.
, RF-A protein 1
, RP-A p70
, replication factor A protein 1
, replication protein A 70 kDa DNA-binding subunit
, single-stranded DNA-binding protein
, replication protein A1, 70kDa
, replication protein A1
, replication protein A 70 kDa DNA-binding subunit-like
, replication protein A (RPA)
, drosophila replication protein A
, replication protein A 70
, single stranded-binding protein 70