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Human Selectin E + CD62e Protein expressed in Human Cells - ABIN2002601
Phillips, Nudelman, Gaeta, Perez, Singhal, Hakomori, Paulson: ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. in Science (New York, N.Y.) 1991
Show all 6 Pubmed References
Levels of E and P selectin (show SELP Proteins) showed positive correlation with the length of stay.
Our study shows a significant association of E-selectin gene polymorphism(Leu554Phe) with essential hypertension.
Circulating CD62E(+) microparticle levels are abnormal in subjects with pre-diabetes.
Neutrophil rolling over E-selectin at precise shear stress transmits tension and catch-bond formation with L-selectin (show SELL Proteins) via sLe(x), resulting in focal clusters that deliver a distinct signal to upshift beta2-integrins to a high-affinity state. Rivipansel effectively blocked formation of selectin catch-bonds, revealing a novel mechanotransduction circuit
E-selectin-dependent rolling promotes adhesion to HA by both physically slowing cells and enabling them to position proximal to the surface, thereby increasing the on rate of adhesion.
High E-selectin expression is associated with breast cancer metastasis.
his study shows that two adhesion molecules, shed as soluble forms, are elevated during the acute phase of leptospirosis: E-selectin and s-ICAM1 (show ICAM1 Proteins). These molecules may interfere with the process of immune cell recruitment to clear Leptospira at tissue levels.
ELAM-1 upregulation may promote disorder in adhesion, and migration of the cells leading to the endometriosis disorder.
Elevated endothelium-related mediators (vWF (show VWF Proteins), E-selectin and EPCR (show PROCR Proteins)) appear to participate in the development of pancreatic necrosis and may be a potential indicator of overall prognosis.
interplay between flow-dependent on-rate and off-rate of E-selectin-ligand bonds determine flow-enhanced cell rolling stability
Chitosan oligosaccharides downregulate the expression of E-selectin and ICAM-1 (show ICAM1 Proteins) by inhibiting the phosphorylation of Mitogen-Activated Protein Kinases and the activation of NF-kappaB (show NFKB1 Proteins) in lipopolysaccharides treated porcine iliac artery endothelial cells.
Increased E-selectin mRNA at end of 20 hours of cold ischemia time might indicate a preactivated state of endothelial cells potentially triggered by bacterial translocation or products.
The e-selectin/biliverdin reductase (show BLVRA Proteins) pathway participates in the inhibitory process of hypoxia in pulmonary artery endothelial cell apoptosis which is mediated by the mitochondrial-dependent apoptosis pathway.
Five single nucleotide polymorphisms (SNPs) from different exons in selectin SELP (show SELP Proteins), two in selectin SELL and one in selectin SELE were taken forward to genotyping in 337 Holstein Friesian heifers using PCR-RFLP.
Study reports that stromal cell-derived factor-1alpha elevated or therapeutically administered in ischemic wounded tissue can stimulate both local endothelial cells (EC) and bone marrow-derived endothelial progenitor cells (EPC (show TCF21 Proteins)) to express reciprocally E-selectin/ligand pairs and thereby enhance EPC (show TCF21 Proteins)-EC interactions.
Before the arrival of tumor cells, the lung-recruited monocytic myeloid-derived suppressor cells produced IL-1beta (show IL1B Proteins), thereby increasing E-selectin expression and promoting tumor cell arrest on endothelial cells.
Inhibiting E-selectin attenuated inflammation in atherosclerotic plaques, likely by reducing leukocyte recruitment into plaques and by mitigating hematopoietic stem and progenitor cell activation in the spleen of mice with myocardial infarction.
In a model of corneal transplantation, P- and E-selectin mediate T cell recruitment to the graft, E-selectin mediates APC (show APC Proteins) trafficking to lymphoid tissue, and blockade of E-selectin has a modest effect on improving long-term graft survival.
Social defeat induced an exposure-dependent increase in mRNA levels of E-selectin, CXCL1 (show CXCL1 Proteins), and CXCL2 (show CXCL2 Proteins) that increased with additional days of social defeat.
The histopathological modification of lupus nephritis by non-nephritogenic bystander IgM (show CD40LG Proteins) antibodies is associated in part with glomerular E-selectin expression.
Data show that actin cytoskeleton regulated CD44 (show CD44 Proteins) membrane mobility and interactions with E-selectin.
Regulatory T cells dynamically regulate P and E selectin ligand expression during multiple challenge contact hypersensitivity.
Systemic inflammation may increase the expression of E-selectin which mediated the lung metastasis of breast cancer in mouse model.
In the absence of either PSGL-1 (show SELPLG Proteins) or E- and P-selectin (show SELP Proteins).
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.
, endothelial adhesion molecule 1
, selectin E (endothelial adhesion molecule 1)
, CD62 antigen-like family member E
, endothelial leukocyte adhesion molecule 1
, leukocyte endothelial cell adhesion molecule 2
, leukocyte-endothelial cell adhesion molecule 2
, selectin, endothelial cell