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Full name:: Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) Proteins (ATF4)

On www.antibodies-online.com are 16 Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) Proteins from 7 different suppliers available. Additionally we are shipping ATF4 Antibodies (349) and ATF4 Kits (19) and many more products for this protein. A total of 404 ATF4 products are currently listed.

Synonyms:: Atf-4, atf4, atf4-a, atf4-b, ATF4-I, atf4-ii, C/ATF, creb-2, creb2, sb:eu681, taxreb67, txreb, wu:fb08f07, wu:fj01c08, wu:fk30b04, zgc:85951, zgc:171702

list all proteins	Gene Name	GeneID	UniProt
	ATF4	468	P18848
	ATF4	79255	Q9ES19
	ATF4	11911	Q06507
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ATF4 Proteins (ATF4) by Origin

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Top referenced ATF4 Proteins

Human ATF4 Protein expressed in Wheat germ - ABIN1345933 : Zhang, Khachigian et al.: Injury-induced platelet-derived growth factor receptor-alpha expression mediated by interleukin-1beta (IL-1beta) release and cooperative transactivation by NF-kappaB and ATF-4: IL-1beta facilitates ... in The Journal of biological chemistry 2009 (PubMed)

More Proteins for ATF4 Interaction Partners

Human Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

PSAT1 (show PSAT1 Proteins), which is overexpressed in ER-negative breast cancers, is activated by ATF4 and promotes cell cycle progression via regulation of the GSK3beta/beta-catenin (show CTNNB1 Proteins)/cyclin D1 (show CCND1 Proteins) pathway.
POSTN (show POSTN Proteins) may function as a protective factor for osteoblasts during this process by inhibiting the eIF2alphaATF4 pathway.
p62 directly targets nuclear transcription factors to control metabolic reprogramming in the microenvironment and repress tumorigenesis, and identifies ATF4 as a synthetic vulnerability in p62-deficient tumor stroma.
results suggest a conditional regulation of KRT16 gene by ATF4 that may be inhibited in normal cells, but engaged during cancer progression. Potential roles of KRT16, FAM129A and HKDC1 genes upregulation in adaptive stress responses and pathologies are discussed
Results provide evidence that the availability of glucose controls ATF4-mediated MITF (show MITF Proteins) suppression to drive melanoma cell proliferation.
Decreased ATF4 expression as a mechanism of acquired resistance to long-term amino acid limitation in cancer cells
These results suggest that p21 (show CDKN1A Proteins) induction plays a vital role in the cellular response to ER stress and indicate that p21 (show CDKN1A Proteins) is a prosurvival effector of ATF4.
GRP78 (show HSPA5 Proteins) inhibition enhances ATF4-induced cell death by the deubiquitination and stabilization of CHOP (show DDIT3 Proteins) in human osteosarcoma cells.
Expression of either dominant-negative or constitutively active mutants of Nrf2 (show GABPA Proteins), ATF4, or c-Jun (show JUN Proteins) confirmed that distinct transcription units are regulated by these transcription factors.
ATF4 contributes to tumor growth of endometrial cancer (EC) by promoting CCL2 (show CCL2 Proteins) and subsequent recruitment of macrophage, and ATF4/CCL2 (show CCL2 Proteins) axis might be a potential therapeutic target for EC.

Rhesus Monkey Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

HIV/SIV exploits the early host antiviral response through GCN2 (show EIF2AK4 Proteins)-ATF4 signaling by utilizing ATF4 for activating the viral LTR transcription to establish initial viral replication

Pig (Porcine) Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

expression levels of porcine ATF4 gene were up-regulated 60 days and 120 days after birth in both breeds and the expression level in Meishan pigs was obviously higher than that in Large White pigs
Tissue transcription analysis revealed that both porcine CREB2 (show ATF2 Proteins) and CREB3 (show CREB3 Proteins) mRNA were ubiquitously detected in all examined tissues.

Xenopus laevis Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

Over-expression of atf4 in embryos interferes with neurogenesis and eye formation.
Unlike other CREB2 (ATF4) proteins, the ATF4 isolated from the gonads of Xenopus embryos contains a consensus phosphorylation site for protein kinase A (PKA).

Mouse (Murine) Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

Golgi stress response elicited by monensin stimulates CSE (show CTH Proteins) by acting via ATF4 with characteristics distinguishable from the endoplasmic reticulum stress response
established Neuro2a cells with edited GADD34 (show PPP1R15A Proteins) and ATF4/GADD34 (show PPP1R15A Proteins) genes and found that ATF4 acts as a proapoptotic factor, but GADD34 (show PPP1R15A Proteins) depletion did not attenuate the expression of cleaved caspase-3 (show CASP3 Proteins) induced by tunicamycin treatment.
Atg7 (show ATG7 Proteins) ablation mainly induced the PERK (show EIF2AK3 Proteins)-ATF4-CHOP (show DDIT3 Proteins) axis of the endoplasmic reticulum (ER) stress response in growth plate chondrocytes.
under nutrient-limiting conditions that stimulate ATF4 activity, TRIB3 (show TRIB3 Proteins) is implicated in the regulation of metabolic adaptation by restraining the transcription of Fgf21 (show FGF21 Proteins).
these findings reveal a new crucial combined effect of the silencing of PERK (show EIF2AK3 Proteins) and ATF4 in modulating ER stressmediated apoptosis during chondrocyte differentiation and proliferation.
Sirt1 (show SIRT1 Proteins) reduced endoplasmic reticulum stress and apoptosis of brown adipocytes in vivo/in vitro by inhibiting Smad3 (show SMAD3 Proteins)/ATF4 signaling pathway.
These findings indicate that the aggregation of S-opsin (show OPN1SW Proteins) induced by exposure to blue -emitting diode light causes endoplasmic reticulum stress, and ATF4 activation in particular.
We hypothesize that the essential role of methionine-charged initiator tRNA in forming ternary complex is responsible for the robust ability of methionine deficiency to induce ATF4 and the ISR even in the absence of GCN2 (show EIF2AK4 Proteins) or eIF2alpha (show EIF2A Proteins) kinase activity.
BTG1 (show BTG1 Proteins) has a role in regulating hepatic lipid metabolism and in preventing ATF4 and SCD1 (show SCD Proteins) from inducing liver steatosis
Transcriptional profiling reveals that mouse neuroblastoma (show ARHGEF16 Proteins) sphere-forming cells acquire a metabolic program characterized by transcriptional activation of the cholesterol and serine-glycine synthesis pathways, primarily as a result of increased expression of sterol regulatory element binding factors and Atf4, respectively

ATF4 Protein Profile

Protein Summary

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.

Alternative names and synonyms associated with ATF4

activating transcription factor 4 (ATF4)
activating transcription factor 4 (atf4)
activating transcription factor 4 (Atf4)
activating transcription factor 4 L homeolog (atf4.L)
activating transcription factor 4a (atf4a)
activating transcription factor 4b (atf4b)
activating transcription factor 4 S homeolog (atf4.S)

Atf-4 protein
atf4 protein
atf4-a protein
atf4-b protein
ATF4-I protein
atf4-ii protein
C/ATF protein
creb-2 protein
creb2 protein
sb:eu681 protein
taxreb67 protein
txreb protein
wu:fb08f07 protein
wu:fj01c08 protein
wu:fk30b04 protein
zgc:85951 protein
zgc:171702 protein

Protein level used designations for ATF4

DNA-binding protein TAXREB67 , cAMP response element-binding protein 2 , cAMP-dependent transcription factor ATF-4 , cAMP-responsive element-binding protein 2 , cyclic AMP-dependent transcription factor ATF-4 , cyclic AMP-responsive element-binding protein 2 , tax-responsive enhancer element B67 , tax-responsive enhancer element-binding protein 67 , activating transcription factor 4 (tax-responsive enhancer element B67) , activating transcription factor ATF-4 , rATF-4 , activating transcription factor 4 , c/EBP-related ATF , tax-responsive enhancer element-binding protein 67 homolog , taxREB67 homolog , Activating Transcription Factor 4 -I , Activating Transcription Factor 4 -II , activating transcription factor 4 S homeolog

GENE ID	SPECIES
468	Homo sapiens
100216465	Ovis aries
395693	Gallus gallus
703965	Macaca mulatta
474503	Canis lupus familiaris
744513	Pan troglodytes
100144302	Sus scrofa
448005	Xenopus (Silurana) tropicalis
79255	Rattus norvegicus
398804	Xenopus laevis
406514	Danio rerio
509107	Bos taurus
556410	Danio rerio
11911	Mus musculus
100732296	Cavia porcellus
101680524	Mustela putorius furo
734165	Xenopus laevis

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