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Human CD14 Protein expressed in Wheat germ - ABIN1348531
Gu, Werner, Bergmann, Whitcomb, Büchler, Fortunato: Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis. in Cell death & disease 2013
Data show that multiple phagocytes are capable of hyperactivation in response to oxPAPC, with CD14 antigen acting as the earliest regulator in this process, serving to capture and transport these lipids to promote inflammatory cell fate decisions.
Data (including data from studies conducted in cells from knockout mice) suggest that signaling via Lpar1 (show LPAR1 Proteins), Cd14, and Scara1 (show MSR1 Proteins) mediates uptake of oxidized LDL by macrophages leading to foam cell formation; lysophosphatidic acid (LPA) induces expression of Cd14 and Scara1 (show MSR1 Proteins) in macrophages. (Lpar1 (show LPAR1 Proteins) = LPA receptor 1 (show LPAR1 Proteins); Cd14 = monocyte differentiation antigen CD14; Scara1 (show MSR1 Proteins) = scavenger receptor class A type I)
Stimul (show TLR4 Proteins)ation of murine peritoneal macrophages with LPS indu (show TLR4 Proteins)ces biphasic accumulation of PI(4,5)P2 with peaks at 10 and 60-90 min that was abrogated when C (show TLR4 Proteins)D14 was removed from the cell surface.
these results indicate that CD14 is a co-receptor of TLR4 (show TLR4 Proteins) in the S100A9 (show S100A9 Proteins)-induced cytokine response.
this study shows that lipid rafts may serve as sites in which LPS (show TLR4 Proteins) receptors (CD14) are sorted for endocytosis, rather than being platforms for the assembly of TLR4 (show TLR4 Proteins)-centered signaling complexes
These findings suggested that the degree of lung injury was reduced during the acute inflammatory reaction when NFkappaB was inhibited, and that the expression of sphingomyelin synthase 2 (show SGMS2 Proteins) may affect the induction of the NFkappaB pathway by lipopolysaccharide through CD14.
Results demonstrate remarkable sophistication of microglial CD14 in enabling, facilitating and moderating innate immune responses to infectious and non-infectious CNS threats of diverse kinds
CD14-mediated lipid signaling induced epithelial apoptosis, whereas TLR4 (show TLR4 Proteins) antagonistically promoted cell survival and cancer development.
fucosyllactose directly inhibits lipopolysaccharide-mediated inflammation during E. coli infection of intestinal epithelial cells through attenuation of CD14 induction.
studies revealed a novel physical association between SP-R210S, CD14, and SR-A (show MSR1 Proteins) leading to an enhanced response to LPS (show TLR4 Proteins), and found that SP-R210L and SP-R210S regulate internalization of CD14 via distinct macropinocytosis-like mechanisms
novel observation that sCD14 compared with lipopolysaccharide binding protein (show LBP Proteins), offers a preferred target to ameliorate TLR especially TLR4 (show TLR4 Proteins)-induced inflammation and insulin (show INS Proteins) resistance in human obesity and metabolic syndrome
For asthma, there was suggestive evidence of a gene-by-environment interaction for the CD14 (show NDUFA2 Proteins) variant rs2569190 (Interaction P = 0.16) but not for the TLR4 (show TLR4 Proteins) variants rs4986790 and rs4986791.
the simultaneous detection of both plasma sCD14 and IL-6 (show IL6 Proteins) is a promising diagnostic approach to identify active pulmonary tuberculosis, and further, measurement of TNF-alpha (show TNF Proteins) and sCD163 (show CD163 Proteins) can identify the most severe cases of tuberculosis.
the methylation levels in the promoter region of CD14 (show NDUFA2 Proteins) gene were higher in the Finnish compared to Russian Karelian children
Anti-apoA-1 IgG are independent predictors of nonfatal incident coronary artery disease in the general population. The strength of this association is dependent on a functional polymorphism of the CD14 receptor gene, a finding suggesting a gene-autoantibody interaction for the development of CAD.
CD14 (show NDUFA2 Proteins) haplotypes and sCD14 are important mediators of lung function among those with COPD (show ARCN1 Proteins) in this occupationally-exposed population.
IL-1beta (show IL1B Proteins)-primed dendritic cells express high levels of CD14 (show NDUFA2 Proteins) that mediate IL-17 (show IL17A Proteins) production through direct interaction with T cells.
The distribution of the CD14 rs2569190 genotypes and allele frequencies showed significant differences between the test and control groups. Prevalence of the polymorphic TT genotype and T allele of the CD14 rs2569190 were significantly increased in GCP patients when compared with healthy controls
Neovascularized atherosclerotic lesions selectively associate with lower blood levels of CD14 (show NDUFA2 Proteins)+ and CD14 (show NDUFA2 Proteins)(high)CD16 (show CD16 Proteins)- monocytes independently of systemic inflammatory activity.
CXCR7 (show CXCR7 Proteins) mediates CD14 (show NDUFA2 Proteins)(+)CD16 (show CD16 Proteins)(+) monocyte transmigration across the blood brain barrier, and is a potential therapeutic target for neuro AIDS.
Transcription levels of TLR2, TLR4 (show TLR4 Proteins), and CD14 in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
Data from an in vitro co-culture model suggest that an early response of endometrium in uterine infection is up-regulation of expression of CD14 and TLR4 (toll-like receptor 4 (show TLR4 Proteins)).
This study study confirmed that expression of CD14 in blood polymorpnuclear cells (PMN (show TBCE Proteins)), resident PMN (show TBCE Proteins) and inflammatory PMN (show TBCE Proteins) from heifer mammary glands was accompanied by apoptosis and necrosis.
data are consistent with a role for lipopolysaccharide binding protein (show LBP Proteins) and soluble CD14 antigen molecules in mediating mammary gland responses to lipopolysaccharide(lipopolysaccharide binding protein- LBP (show LBP Proteins))
Toll-like receptor 4 (show TLR4 Proteins) mRNA and CD14 mRNA and protein were detected in bovine endometrial stromal and epithelial cells by RT-PCR and flow cytometry.
SNP and association analyses have provided baseline information that may be used at defining the role of CD14 in mediating bacterial infections
VB-201 may counter inflammation where TLR-2 and/or CD14 complicity is essential, and is therefore beneficial for the treatment of atherosclerosis.
Determine native soluble CD14 concentrations in serum from healthy and septic foals, in the colostrum of healthy mares and in plasma from adult horses with recurrent airway obstruction and control horses.
CD14 mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein.
monocyte differentiation antigen CD14
, myeloid cell-specific leucine-rich glycoprotein
, CD14 antigen
, lipopolysaccharide receptor