anti-Human CD36 antibody for Functional Studies

Recommended CD36 Antibody (supplied by: Log in to see )

Antigen
CD36 Molecule (thrombospondin Receptor) (CD36) Antibodies
  • BDPLT10
  • CHDS7
  • FAT
  • GP3B
  • GP4
  • GPIV
  • PASIV
  • SCARB3
  • Fat
  • Scarb3
  • GPIIIB
  • PAS-4
  • zgc:92513
  • CD36 molecule
  • CD36 molecule (thrombospondin receptor)
  • CD36
  • Cd36
  • cd36
Reactivity
Human
363
152
92
8
7
4
4
3
3
3
1
Host
Mouse
254
139
48
12
2
Clonality
Monoclonal
Conjugate
This CD36 antibody is conjugated to Biotin
53
27
21
19
10
9
8
5
5
5
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
Functional Studies (Func), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)
292
144
134
90
65
40
40
39
37
28
14
3
3
3
3
3
3
2
2
2
2
1
1
1
1
Options
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Catalog No. ABIN2192000
$ 405.93
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
12.572235 ABIN2192001 Func IA FACS IF FITC Mouse Log in to see FA6-152 1
12.572235 ABIN2191999 Func IA FACS IF Mouse Log in to see FA6-152 1
4 ABIN119475 Func FACS IHC (fro) WB Mouse IgM Log in to see SM0 5
1 ABIN1106321 Func EIA IHC (fro) IF WB Mouse IgG1 Log in to see FA6-152 5
1 ABIN210377 Func FACS WB Mouse IgM Log in to see 0
1 ABIN343926 FACS Func Mouse IgA Log in to see JC63-1 0
1 ABIN1106322 Func EIA IHC (fro) IF WB Biotin Mouse IgG1 Log in to see FA6-152 5
1 ABIN1106325 Func EIA IHC (fro) IF IP FITC Mouse IgG1 Log in to see FA6-152 5
1 ABIN1106318 Func IHC (fro) IF Mouse IgG1 Log in to see VM58 2
1 ABIN6252764 ELISA FACS Func IF WB Mouse IgG1, kappa Log in to see 1E8- 0
1 ABIN6252763 FACS Func IF WB Mouse IgG2a, kappa Log in to see 185-1G2 0
1 ABIN210200 FACS Func IHC IHC (fro) IP WB Mouse IgM Log in to see 0
1 ABIN6296378 FACS Func IF Mouse Log in to see 0
1 ABIN6296379 ELISA FACS Func IF Mouse Log in to see 0
1 ABIN6297679 FACS Func IF Mouse Log in to see 0
1 ABIN3024365 Func FACS IF Mouse IgG2a, kappa Log in to see 185-1G2 0
1 ABIN3025956 Func FACS IF Mouse IgG2b, kappa Log in to see 1A7 0
1 ABIN3025958 Func FACS IF ELISA Mouse IgG1, kappa Log in to see 1E8- 0
1 ABIN3024366 Func FACS IF Mouse IgG2a, kappa Log in to see 185-1G2 0
1 ABIN3025957 Func FACS IF Mouse IgG2b, kappa Log in to see 1A7 0

General

Antigen CD36 Molecule (thrombospondin Receptor) (CD36) Antibodies
Reactivity Human
(363), (152), (92), (8), (7), (4), (4), (3), (3), (3), (1)
Host Mouse
(254), (139), (48), (12), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD36 antibody is conjugated to Biotin
(53), (27), (21), (19), (10), (9), (8), (5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application Functional Studies (Func), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)
(292), (144), (134), (90), (65), (40), (40), (39), (37), (28), (14), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-CD36 Antibody

Target Details CD36 Application Details Handling References for anti-CD36 antibody (ABIN2192000) Images
Sterility 0.2 μm filtered
Clone FA6-152
Plasmids, Primers & others

Target Details CD36

Product Details anti-CD36 Antibody Application Details Handling References for anti-CD36 antibody (ABIN2192000) Images back to top
Antigen
Alternative Name CD36 (CD36 Antibody Abstract)
Background Monoclonal antibody FA6-152 recognizes human CD36 (88- kDa), a cell surface class B scavenger receptor, also known as thrombospondin receptor CD36 is a heavily N-glycosylated transmembrane protein of ~88 kDa with two short intracellular domains and a large extracellular domain. The protein is sensitive for neuroaminidase, resulting in a shift from 88 to 85 kDa. CD36 is expressed on platelets, mature monocytes and macrophages, microvascular endothelial cells, mammary endothelial cells, during stages of erythroid cell development and on some macrophage derived dendritic cells. The antibody recognizes adult and fetal monocytes, platelets and reticulocytes, but doesn't stain lymphocytes and granulocytes. Reactivity has also been found in small intestine, kidney, liver and thyroid. CD36 expression is primarily controlled by the transcription heterodimer PPARg-RXR (peroxisome proliferator-activated receptor-g-retinoid-X-receptor). CD36 is preferentially found within lipid rafts, which facilitates its association with receptors, signaling and adaptor molecules. It is a receptor and transporter of oxidized lipids and long chain fatty acids. CD36 has been implicated in many biological processes including angiogenesis, phagocytosis, inflammation, and lipid and glucose metabolism. Several in vivo models support the role of the thrombospondin / CD36 system in angiogenesis and tumor growth. An important role for CD36 has been found in Malaria as major receptor for P. falciparum-infected red blood cells. CD36 is associated with Src-family kinases and with the integrins α3β1 and α6β1. Recently, CD36 has been identified as a protein that is required for toll like receptor (TLR2) recognition of di-acylated bacterial lipopeptides and lipoteichoic acid4. Furthermore, CD36 has been shown to function as phagocytic receptor for apoptotic cells. Many different ligands have been reported to interact with CD36, suggesting that CD36 could recognize a structure-based domain rather than specific contact residues. Monoclonal antibody FA6-152 blocks the biological activity of CD36 by blocking collagen/thrombospondin binding. The antibody agglutinates fetal but not adult erythrocytes. Aliases GPIV, FAT, platelet glycoprotein 4, thrombospondin receptor Immunogen 20-Weeks-old fetal erythrocytes
Pathways TLR Signaling, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism

Application Details

Product Details anti-CD36 Antibody Target Details CD36 Handling References for anti-CD36 antibody (ABIN2192000) Images back to top
Application Notes For immunohistology and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Positive HEL cells control
Restrictions For Research Use only

Handling

Product Details anti-CD36 Antibody Target Details CD36 Application Details References for anti-CD36 antibody (ABIN2192000) Images back to top
Buffer PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

References for anti-CD36 antibody (ABIN2192000)

Product Details anti-CD36 Antibody Target Details CD36 Application Details Handling Images back to top
Background publications

Edelman, Vinci, Villeval, Vainchenker, Henri, Miglierina, Rouger, Reviron, Breton-Gorius, Sureau: "A monoclonal antibody against an erythrocyte ontogenic antigen identifies fetal and adult erythroid progenitors." in: Blood, Vol. 67, Issue 1, pp. 56-63, 1986