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Human CD36 Protein expressed in Human Cells - ABIN2003345
Xu, Efremov, Li, Lai, Dao, Lim, Cao: Probing the cytoadherence of malaria infected red blood cells under flow. in PLoS ONE 2013
Significant up-regulation of PBMCs CAP1 (show PRSS8 Proteins), CD36 mRNA and plasma resistin (show RETN Proteins) found in significant coronary artery disease, as well as in nonsignificant coronary artery disease compared to control group, indicates that resistin (show RETN Proteins) could be able to exert its effects stronger on cells with up-regulated CAP1 (show PRSS8 Proteins) mRNA thus contributing atherosclerosis development.
CD36, also known as FA translocase (FAT), that functions as a transmembrane protein and mediates the uptake of FAs (show FAS Proteins), is observed to be highly expressed in breast cancer tissues. Furthermore, the anti-proliferation effect caused by the SCD1 (show SCD Proteins) inhibitor can not be reversed by exogenous oleic acid supplementation in CD36 knockdown breast cancer cells
Results showed that CD36 genotypes were not associated with the progression to T2DM independently. however, the study suggested a positive interaction between the CD36 variants and obesity on T2DM susceptibility, which might be through a cardiometabolic disorder.
Taken together, these findings indicate that rs1194182 polymorphism in the CD36 gene was associated with intracerebral hemorrhage, and genotype GG could be an independent predictor.
CD36 marks adipocyte progenitor cells with pronounced adipogenic potential, most probably by facilitating lipid uptake.
sCD36 levels increased with the level of intrahepatic lipid, insulin (show INS Proteins) resistance and dyslipidemia; association with markers of obesity and the association with hepatic CD36 mRNA expression suggest that excess sCD36 in NAFLD patients is derived from the hepatocytes, which may support that CD36 is involved in NAFLD development; an unhealthy CD36 expression in adipose and hepatic tissue may shift the fatty-acid load to liver
In conclusion, oxLDL induced MALAT1 transcription and MALAT1 recruits beta-catenin (show CTNNB1 Proteins) to binding sites on the CD36 promoter to induce CD36 expression, which enhances lipid uptake in macrophages.
Based on these findings, we conclude that an acetylation-deacetylation signaling step might regulate CD36 functional activity and subsequent lipid accumulation and caspase 3 (show CASP3 Proteins) activation in pancreatic beta cells exposed to GLT (show SLC1A2 Proteins) conditions.
These results indicated that AKT (show AKT1 Proteins)-PPARgamma (show PPARG Proteins) signaling pathway mediated HG-induced lipid deposition by upregulating CD36 expression in HK-2 (show HK2 Proteins) cells and that inhibition of AKT (show AKT1 Proteins)-PPARgamma (show PPARG Proteins) signaling pathway had the potential beneficial effects of reducing lipid deposition in diabetic kidney.
CD36/STAT3 (show STAT3 Proteins) SNPs linked to cardiovascular disease may modulate the effects of different diets on biochemical and inflammatory markers among these subjects.
Amyloid-beta inhibits No-cGMP signaling in a CD36- and CD47 (show CD47 Proteins)-dependent manner
Niacin Reduces serum level and adipose mRNA expression of leptin (show LEP Proteins) and up-regulates PPARgamma (show PPARG Proteins) and CD36 mRNA expression in hypercholesterolemic rabbits.
TMP upregulated the protein stability of ABCA1 (show ABCA1 Proteins) without affecting ABCG1 (show ABCG1 Proteins). Accordingly, TMP regulated the expression of SR-A (show MSR1 Proteins), CD36, ABCA1 (show ABCA1 Proteins) and ABCG1 (show ABCG1 Proteins) in aortas of ApoE (show APOE Proteins)-/- mice, which resembled the findings observed in macrophages.
atherogenic condition could activate eosinophils and modulate the phenotype of macrophages (from M2 to M1 phenotype), in part, through the CD36 receptor signaling
CD36 plays a role in the perception of specific odour-active volatile compounds in the nasal cavity.
CD36 plays an important role in modifying gallstone susceptibility in mice
CD36 is essential for endurance improvement, changes in whole-body metabolism, and efficient peroxisome-proliferator activated receptors (PPAR (show PPARA Proteins))-related transcriptional responses in the muscle with exercise training.
development of obesity-related chronic kidney disease via CD36 in mice
The low magnitude of opsonin-independent phagocytosis of Escherichia coli and unimpaired phagocytosis of Staphylococcus aureus in SR-A (show MSR1 Proteins)- or CD36-deficient macrophages indicate that the defect in this process might not be responsible for the reported impaired bacteria clearance in mice deficient in these receptors.
Results show that CD36 deficiency promoted the development of nonalcoholic steatohepatitis by facilitating the transcription of MCP-1 (show CPT1B Proteins) in hepatocytes due to the reduction of ROS (show ROS1 Proteins) and nuclear HDAC2 (show HDAC2 Proteins). These results provide evidence that decreased ROS (show ROS1 Proteins) production by CD36 deletion was also harmful for livers. The fine balance of CD36 plays an important role in maintaining balances of hepatic ROS (show ROS1 Proteins) and nuclear HDAC2 (show HDAC2 Proteins).
Coexpression of the Olfr287 in olfactory sensory neurons with CD36 suggests that only a specific set of olfactory receptors may be coexpressed with CD36 in these neurons.
Neither the lack of CD36 nor the deletion of the smac (show DIABLO Proteins) gene from Plasmodium chabaudi significantly impacted on acute-stage pathology or parasite sequestration. By contrast, in the absence of ICAM-1 (show ICAM1 Proteins), infected animals experience less anaemia and weight loss, reduced parasite accumulation in both spleen and liver and higher peripheral blood parasitaemia during acute stage malaria.
These results suggest that increased expression of hepatic CD36 and SREBP-1 (show SREBF1 Proteins) is relevant in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.
Gammadelta T cells express CD36 and it contributes to responses by these cells to microbial lipoteichoic acid.
The findings of this study indicated that Cd36 is a candidate lipid sensor involved in the sensory detection of fatty acid in zebrafish.
Zebrafish Cd36 is a microbial-binding molecule.
The putative role for Cd36 in immune responses of fish in the context of other members of the scavenger receptor class B family, is discussed.
CD36 plays a vital role in the LPS (show IRF6 Proteins)-induced activation of downstream signaling cascades and mediates E. coli phagocytosis via TLR4 (show TLR4 Proteins) in pGMECs, which offers a novel treatment strategy for mastitis
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
CD36 antigen (collagen type I receptor, thrombospondin receptor)
, PAS IV
, PAS-4 protein
, cluster determinant 36
, fatty acid translocase
, glycoprotein IIIb
, leukocyte differentiation antigen CD36
, platelet glycoprotein 4
, platelet glycoprotein IV
, scavenger receptor class B, member 3
, adipocyte membrane protein
, collagen type I receptor thrombospondin receptor
, fatty acid transport protein
, fatty acid translocase/CD36
, CD36 antigen
, collagen type I receptor, thrombospondin receptor