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Human CD36 Protein expressed in Human Cells - ABIN2003345
Xu, Efremov, Li, Lai, Dao, Lim, Cao: Probing the cytoadherence of malaria infected red blood cells under flow. in PLoS ONE 2013
We identified CD36 as one of the most significantly upregulated lipid-related genes in senescent cells. We showed that overexpression of CD36 in proliferating cells resulted in a senescence-like phenotype. We hypothesize that CD36 overexpression leads to changes in membrane remodeling and plausibly mediate SASP (show ASPRV1 Proteins) release.
Our findings indicated that hepatic stellate cells-derived COMP (show COMP Proteins) collaborated with CD36 and subsequently played an essential role in MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) and PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)-mediated hepatocellular carcinoma (HCC (show FAM126A Proteins)) progression. COMP (show COMP Proteins) might act as a promising target for the diagnosis and treatment of aggressive HCC (show FAM126A Proteins).
Study shows the CD36 expression level downregulated in the lung cancer. Further, results found that the high methylation of CD36 corresponding to its low expression in lung cancer played an important role in the procession of lung cancer.
The rs7755 and rs3211956 loci polymorphisms of CD36 gene and genotype E2/E3, E3/E4, E4/E4 of ApoE (show APOE Proteins) gene, and E2 and E4 alleles were statistically related with Alzheimer disease.
This study suggests that T2D patients with different genotypes at CD36, NOS3 and PPARG (show PPARG Proteins) respond differentially to intervention of omega-3 supplements in blood lipid profiles.
Gene expressions of YKL-40 (show CHI3L1 Proteins) and CD36 were significantly higher in patients with T2DM (>5 yr) with hypertension compared to healthy controls (P=0.006). In addition, a significant increase in serum levels of sCD36, PPAR-gamma (show PPARG Proteins) and YKL-40 (show CHI3L1 Proteins) was observed in patients with T2DM (>5 yr) with hypertension compared to healthy controls
genetic association studies in population of preschool-aged children in Guelph, Ontario: Data suggest that SNPs in CD36 (rs1761667), TAS1R2 (show TAS1R2 Proteins) (rs35874116), and TAS2R38 (show TAS2R38 Proteins) (rs713598) are associated with snacking behavior in the population studied. [PILOT PROJECTS]
CD36 is important for muscle glucose metabolism and optimal insulin (show INS Proteins) responsiveness.
Significant up-regulation of PBMCs CAP1 (show PRSS8 Proteins), CD36 mRNA and plasma resistin (show RETN Proteins) found in significant coronary artery disease, as well as in nonsignificant coronary artery disease compared to control group, indicates that resistin (show RETN Proteins) could be able to exert its effects stronger on cells with up-regulated CAP1 (show PRSS8 Proteins) mRNA thus contributing atherosclerosis development.
CD36, also known as FA translocase (FAT), that functions as a transmembrane protein and mediates the uptake of FAs (show FAS Proteins), is observed to be highly expressed in breast cancer tissues. Furthermore, the anti-proliferation effect caused by the SCD1 (show SCD Proteins) inhibitor can not be reversed by exogenous oleic acid supplementation in CD36 knockdown breast cancer cells
Amyloid-beta inhibits No-cGMP signaling in a CD36- and CD47 (show CD47 Proteins)-dependent manner
Niacin Reduces serum level and adipose mRNA expression of leptin (show LEP Proteins) and up-regulates PPARgamma (show PPARG Proteins) and CD36 mRNA expression in hypercholesterolemic rabbits.
SIRT1 (show SIRT1 Proteins) upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF-kappaB (show NFKB1 Proteins) pathway in mouse Kupffer cells.
Cd36 deficiency led to reduced expression of phagocytosis receptor Mertk (show MERTK Proteins) and nuclear receptor Nr4a1 (show NR4A1 Proteins) in cardiac macrophages, the latter previously shown to be required for phagocyte survival.
CD36 plays an important proinflammatory role in ConA-induced liver injury by promoting hepatic inflammation and mediating the proapoptotic effect of chemokine (show CCL1 Proteins) CXCL10 (show CXCL10 Proteins), and therefore, may be a potential therapeutic target for immune-mediated hepatitis
both paracrine and endocrine effects of adiponectin may contribute to reduced reactive oxygen species generation and apoptosis after MI/R, in a CD36-dependent manner
Overexpressing STAMP2 (show STEAP4 Proteins) attenuates adipose tissue angiogenesis and insulin (show INS Proteins) resistance in diabetic ApoE (show APOE Proteins)(-/-) /LDLR (show LDLR Proteins)(-/-) mouse via a PPARgamma (show PPARG Proteins)/CD36 pathway.
This study demonstrated the CD36 deletion in mice (CD36(-/-) mice) resulted in an attenuated progression of chronic epilepsy compared with wild-type (WT) mice.
TMP upregulated the protein stability of ABCA1 (show ABCA1 Proteins) without affecting ABCG1 (show ABCG1 Proteins). Accordingly, TMP regulated the expression of SR-A (show MSR1 Proteins), CD36, ABCA1 (show ABCA1 Proteins) and ABCG1 (show ABCG1 Proteins) in aortas of ApoE (show APOE Proteins)-/- mice, which resembled the findings observed in macrophages.
atherogenic condition could activate eosinophils and modulate the phenotype of macrophages (from M2 to M1 phenotype), in part, through the CD36 receptor signaling
CD36 plays a role in the perception of specific odour-active volatile compounds in the nasal cavity.
These results suggest that increased expression of hepatic CD36 and SREBP-1 (show SREBF1 Proteins) is relevant in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.
Gammadelta T cells express CD36 and it contributes to responses by these cells to microbial lipoteichoic acid.
The findings of this study indicated that Cd36 is a candidate lipid sensor involved in the sensory detection of fatty acid in zebrafish.
Zebrafish Cd36 is a microbial-binding molecule.
The putative role for Cd36 in immune responses of fish in the context of other members of the scavenger receptor class B family, is discussed.
CD36 plays a vital role in the LPS (show IRF6 Proteins)-induced activation of downstream signaling cascades and mediates E. coli phagocytosis via TLR4 (show TLR4 Proteins) in pGMECs, which offers a novel treatment strategy for mastitis
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
CD36 antigen (collagen type I receptor, thrombospondin receptor)
, PAS IV
, PAS-4 protein
, cluster determinant 36
, fatty acid translocase
, glycoprotein IIIb
, leukocyte differentiation antigen CD36
, platelet glycoprotein 4
, platelet glycoprotein IV
, scavenger receptor class B, member 3
, adipocyte membrane protein
, collagen type I receptor thrombospondin receptor
, fatty acid transport protein
, fatty acid translocase/CD36
, CD36 antigen
, collagen type I receptor, thrombospondin receptor