anti-Rat (Rattus) IRF7 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended IRF7 Antibody (supplied by: Log in to see )

Antigen
Interferon Regulatory Factor 7 (IRF7) Antibodies
  • wu:fl24c03
  • zgc:66043
  • zgc:77947
  • IRF7
  • irf7
  • IRF-7H
  • IRF7A
  • IRF7B
  • IRF7C
  • IRF7H
  • interferon regulatory factor 7
  • irf7
  • IRF7
  • Irf7
Epitope
pSer471, pSer472, AA 450-490
26
22
15
14
14
14
6
5
5
4
4
3
2
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
149
59
55
3
2
2
2
2
1
1
Host
Rabbit
107
42
Clonality
Polyclonal
Conjugate
This IRF7 antibody is un-conjugated
7
6
6
6
6
6
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
103
51
26
25
25
10
6
5
4
2
2
1
1
1
Options
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Catalog No. ABIN742703
$ 340.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
14.5 ABIN682603 IF (p) IHC (p) WB Rabbit IgG AA 420-470 Log in to see Polyclonal 3
1 ABIN903073 IF (p) Alexa Fluor 488 Rabbit IgG AA 420-470 Log in to see Polyclonal 0
1 ABIN903077 IF (p) Alexa Fluor 647 Rabbit IgG AA 420-470 Log in to see Polyclonal 0
1 ABIN903074 IF (p) Alexa Fluor 350 Rabbit IgG AA 420-470 Log in to see Polyclonal 0
1 ABIN903075 IF (p) Alexa Fluor 555 Rabbit IgG AA 420-470 Log in to see Polyclonal 0
1 ABIN742706 IF (p) Cy3 Rabbit IgG pSer471, pSer472, AA 450-490 Log in to see Polyclonal 0
1 ABIN742707 IF (p) Cy5 Rabbit IgG pSer471, pSer472, AA 450-490 Log in to see Polyclonal 0
1 ABIN742708 IF (p) Cy5.5 Rabbit IgG pSer471, pSer472, AA 450-490 Log in to see Polyclonal 0
1 ABIN742709 IF (p) Cy7 Rabbit IgG pSer471, pSer472, AA 450-490 Log in to see Polyclonal 0
1 ABIN742710 IF (p) FITC Rabbit IgG pSer471, pSer472, AA 450-490 Log in to see Polyclonal 0
1 ABIN682608 IF (p) Cy5.5 Rabbit IgG AA 420-470 Log in to see Polyclonal 0
1 ABIN682606 IF (p) Cy3 Rabbit IgG AA 420-470 Log in to see Polyclonal 0
1 ABIN682607 IF (p) Cy5 Rabbit IgG AA 420-470 Log in to see Polyclonal 0
1 ABIN682609 IF (p) Cy7 Rabbit IgG AA 420-470 Log in to see Polyclonal 0
1 ABIN682610 IF (p) FITC Rabbit IgG AA 420-470 Log in to see Polyclonal 0
1 ABIN876334 IF (p) Alexa Fluor 488 Rabbit IgG pSer471, pSer472, AA 450-490 Log in to see Polyclonal 0
1 ABIN876336 IF (p) Alexa Fluor 647 Rabbit IgG pSer471, pSer472, AA 450-490 Log in to see Polyclonal 0
1 ABIN876338 IF (p) Alexa Fluor 350 Rabbit IgG pSer471, pSer472, AA 450-490 Log in to see Polyclonal 0
1 ABIN876335 IF (p) Alexa Fluor 555 Rabbit IgG pSer471, pSer472, AA 450-490 Log in to see Polyclonal 0
1 ABIN2814920 IF (p) Alexa Fluor 594 Rabbit IgG AA 420-470 Log in to see Polyclonal 0

General

Antigen Interferon Regulatory Factor 7 (IRF7) Antibodies
Epitope pSer471, pSer472, AA 450-490
(26), (22), (15), (14), (14), (14), (6), (5), (5), (4), (4), (3), (2), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(149), (59), (55), (3), (2), (2), (2), (2), (1), (1)
Host Rabbit
(107), (42)
Clonality
Polyclonal
Conjugate This IRF7 antibody is un-conjugated
(7), (6), (6), (6), (6), (6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(103), (51), (26), (25), (25), (10), (6), (5), (4), (2), (2), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-IRF7 Antibody

Target Details IRF7 Application Details Handling References for anti-IRF7 antibody (ABIN742703) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human IRF7 around the phosphorylation site of Ser471/472
Isotype IgG
Plasmids, Primers & others

Target Details IRF7

Product Details anti-IRF7 Antibody Application Details Handling References for anti-IRF7 antibody (ABIN742703) Images back to top
Antigen
Alternative Name Irf7 (IRF7 Antibody Abstract)
Background

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.

Subcellular location: Nucleus

Synonyms: IRF7A, IRF7B, IRF7C, IRF7H, IRF-7H, Interferon regulatory factor 7, IRF-7, IRF7

Gene ID 3665
UniProt Q92985
Pathways TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagy

Application Details

Product Details anti-IRF7 Antibody Target Details IRF7 Handling References for anti-IRF7 antibody (ABIN742703) Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-IRF7 Antibody Target Details IRF7 Application Details References for anti-IRF7 antibody (ABIN742703) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-IRF7 antibody (ABIN742703)

Product Details anti-IRF7 Antibody Target Details IRF7 Application Details Handling Images back to top
Product cited in:

Le Bel, Gosselin: "Leukotriene B4 Enhances NOD2-Dependent Innate Response against Influenza Virus Infection." in: PLoS ONE, Vol. 10, Issue 10, pp. e0139856, 2015 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)). Further details: Sample: Lung

Han, Choi, Uyangaa, Kim, Kim, Kim, Kim, Eo: "Distinct dictation of Japanese encephalitis virus-induced neuroinflammation and lethality via triggering TLR3 and TLR4 signal pathways." in: PLoS pathogens, Vol. 10, Issue 9, pp. e1004319, 2014 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).

Menasria, Boivin, Lebel, Piret, Gosselin, Boivin: "Both TRIF and IPS-1 Adaptor Proteins Contribute to the Cerebral Innate Immune Response against Herpes Simplex Virus 1 Infection." in: Journal of virology, Vol. 87, Issue 13, pp. 7301-8, 2013 Method employed by authors: Western Blotting (WB)

Images

Product Details anti-IRF7 Antibody Target Details IRF7 Application Details Handling References for anti-IRF7 antibody (ABIN742703) back to top
Supplier Images
SDS-PAGE (SDS) image for anti-Interferon Regulatory Factor 7 (IRF7) (AA 450-490), (pSer471), (pSer472) antibody (ABIN742703) Lane 1: mouse embryo lysates Lane 2: mouse brain lysates probed with Anti Phospho-IRF...
Immunohistochemistry (IHC) image for anti-Interferon Regulatory Factor 7 (IRF7) (AA 450-490), (pSer471), (pSer472) antibody (ABIN742703) Formalin-fixed and paraffin embedded mouse pancreas tissue labeled with Anti-Phospho-...
Immunohistochemistry (IHC) image for anti-Interferon Regulatory Factor 7 (IRF7) (AA 450-490), (pSer471), (pSer472) antibody (ABIN742703) Formalin-fixed and paraffin embedded rat spleen tissue labeled with Anti-Phospho-IRF7...
Western Blotting (WB) image for anti-Interferon Regulatory Factor 7 (IRF7) (AA 450-490), (pSer471), (pSer472) antibody (ABIN742703) Lane 1: Mouse uterus lysates, Lane 2: Mouse large intestine lysates probed with IRF7 ...