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General |
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Antigen | Lipopolysaccharide Binding Protein (LBP) Antibodies |
Reactivity | Cow (Bovine), Dog (Canine), Goat, Human, Monkey, Pig (Porcine), Rabbit, Rat (Rattus), Sheep (Ovine) Alternatives |
Host | Mouse Alternatives |
Clonality (Clone) | |
Conjugate | This LBP antibody is un-conjugated Alternatives |
Application |
ELISA (Capture), ELISA (Detection), Functional Studies (Func), Immunoprecipitation (IP)
Alternatives
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Supplier | Log in to see |
Product Details anti-LBP AntibodyTarget Details LBP Application Details Handling Images |
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No Cross-Reactivity | Mouse (Murine), Horse (Equine) |
Cross-Reactivity (Details) | Species reactivity (tested):Human, bovine, canine, goat, monkey, rabbit, rat, sheep, swine. |
Purification | Protein G |
Clone | 6G3 |
Isotype | IgG1 |
Plasmids, Primers & others | |
Target Details LBPProduct Details anti-LBP Antibody Application Details Handling Images back to top |
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Antigen | |
Alternative Name | LBP (LBP Antibody Abstract) |
Background | LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000 fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.Synonyms: Lipopolysaccharide-binding protein |
UniProt | P18428 |
Pathways | TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process |
Application DetailsProduct Details anti-LBP Antibody Target Details LBP Handling Images back to top |
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Application Notes | Optimal working dilution should be determined by the investigator. |
Restrictions | For Research Use only |
HandlingProduct Details anti-LBP Antibody Target Details LBP Application Details Images back to top |
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Concentration | 0.1 mg/mL |
Buffer | PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin |
Preservative | Sodium azide |
Precaution of Use | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Storage | 4 °C |
Storage Comment | Store at 2 - 8 °C. |