anti-Rat (Rattus) TANK-Binding Kinase 1 antibody for ELISA

Recommended TANK-Binding Kinase 1 Antibody (supplied by: Log in to see )

Antigen
TANK-Binding Kinase 1 (TBK1) Antibodies
  • nak
  • t2k
  • TBK1
  • wu:fk70c05
  • zgc:136548
  • NAK
  • T2K
  • 1200008B05Rik
  • AI462036
  • AW048562
  • TANK binding kinase 1 L homeolog
  • TANK binding kinase 1
  • TANK-binding kinase 1
  • tbk1.L
  • TBK1
  • tbk1
  • Tbk1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
132
84
48
27
26
10
10
9
8
5
5
4
3
2
2
2
2
1
1
Host
Rabbit
104
34
13
Clonality
Polyclonal
Conjugate
Un-conjugated
10
10
9
7
5
5
3
3
1
1
1
1
1
1
1
1
1
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
133
69
61
31
23
17
9
6
3
2
2
2
1
Supplier
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Catalog No. ABIN6265480
$ 390.77
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2747621 ELISA IHC IP WB Rabbit IgG 2nd Cytoplasmic Loop Log in to see Polyclonal 0
1 ABIN2750604 ELISA IHC IP WB FITC Rabbit IgG 2nd Cytoplasmic Loop Log in to see Polyclonal 0
1 ABIN5558148 ELISA IHC IP WB Biotin Rabbit Log in to see Polyclonal 0

General

Antigen TANK-Binding Kinase 1 (TBK1) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(132), (84), (48), (27), (26), (10), (10), (9), (8), (5), (5), (4), (3), (2), (2), (2), (2), (1), (1)
Host Rabbit
(104), (34), (13)
Clonality
Polyclonal
Conjugate Un-conjugated
(10), (10), (9), (7), (5), (5), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
(133), (69), (61), (31), (23), (17), (9), (6), (3), (2), (2), (2), (1)
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Product details

Target Details Application Details Handling Images
Specificity TBK1 Antibody detects endogenous levels of total TBK1
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Immunogen A synthesized peptide derived from human TBK1
Isotype IgG

Target Details

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Antigen
Alternative Name TBK1 (TBK1 Antibody Abstract)
Background

Description: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates and activates AKT1 (PubMed:21464307). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125).

Gene: TBK1

Molecular Weight 84kDa
Gene ID 29110
UniProt Q9UHD2
Pathways TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades

Application Details

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Application Notes WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
Restrictions For Research Use only

Handling

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Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20 °C.Stable for 12 months from date of receipt
Expiry Date 12 months

Images

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Supplier Images
Western Blotting (WB) image for anti-TANK-Binding Kinase 1 (TBK1) antibody (ABIN6265480) Western blot analysis of Hela whole cell lysates, using TBK1 Antibody. The lane on t...
Immunohistochemistry (IHC) image for anti-TANK-Binding Kinase 1 (TBK1) antibody (ABIN6265480) ABIN6277285 at 1/100 staining Human gastric tissue by IHC-P. The sample was formaldeh...