anti-Human TICAM1 antibody for Western Blotting

Recommended TICAM1 Antibody (supplied by: Log in to see )

Antigen
Toll-Like Receptor Adaptor Molecule 1 (TICAM1) Antibodies
  • IIAE6
  • MyD88-3
  • PRVTIRB
  • TICAM-1
  • TRIF
  • AW046014
  • AW547018
  • trif
  • toll like receptor adaptor molecule 1
  • toll-like receptor adaptor molecule 1
  • TICAM1
  • Ticam1
  • ticam1
Reactivity
Mouse (Murine), Rat (Rattus), Human
83
32
15
4
4
1
1
Host
Rabbit
77
8
8
Clonality
Polyclonal
Conjugate
This TICAM1 antibody is un-conjugated
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
85
32
18
17
13
8
8
4
4
2
1
1
Options
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Available images

Catalog No. ABIN3021572
$ 393.25
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
21.123726 ABIN266066 ICC IF IP SimWes WB Rabbit Internal Region Log in to see Polyclonal 27
18.531807 ABIN2855929 ICC IF WB Rabbit IgG C-Term Log in to see Polyclonal 0
16.697172 ABIN1871543 ICC IHC WB Rabbit IgG AA 443-685 Log in to see Polyclonal 0
16.697172 ABIN1875095 IHC WB Rabbit IgG Log in to see Polyclonal 0
16.697172 ABIN2903154 IF/ICC IHC IP WB Rabbit AA 443-685 Log in to see Polyclonal 0
15.197171 ABIN3044491 IHC (fro) IHC (p) WB Rabbit IgG AA 692-712, C-Term Log in to see Polyclonal 1
13.697171 ABIN6265566 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 0
13.697171 ABIN3029185 IHC (fro) IHC (p) WB Rabbit Ig Fraction C-Term Log in to see Polyclonal 0
12.197171 ABIN6672552 IHC WB Rabbit IgG Log in to see Polyclonal 1
12.197171 ABIN541214 IHC (p) WB Rabbit Log in to see Polyclonal 3
11.834635 ABIN2613488 ELISA WB Goat Internal Region Log in to see Polyclonal 0
11.834635 ABIN4902391 ELISA WB Rabbit IgG AA 663-712 Log in to see Polyclonal 0
11.834635 ABIN6149149 WB Rabbit Log in to see Polyclonal 0
10 ABIN213993 IHC IHC (p) WB Rabbit IgG C-Term Log in to see Polyclonal 0
10 ABIN6292306 IHC WB Rabbit IgG Log in to see Polyclonal 0
9.197171 ABIN1881885 WB Rabbit AA 115-143, N-Term Log in to see Polyclonal 5
9.197171 ABIN537469 WB Rabbit Log in to see Polyclonal 3
7.697171 ABIN3223003 IHC WB Rabbit C-Term Log in to see Polyclonal 0
7.697171 ABIN1030771 IHC ELISA WB Rabbit C-Term Log in to see Polyclonal 0
7.697171 ABIN3029184 ELISA WB Rabbit Ig Fraction AA 115-143 Log in to see Polyclonal 0

General

Antigen Toll-Like Receptor Adaptor Molecule 1 (TICAM1) Antibodies
Reactivity Mouse (Murine), Rat (Rattus), Human
(83), (32), (15), (4), (4), (1), (1)
Host Rabbit
(77), (8), (8)
Clonality
Polyclonal
Conjugate This TICAM1 antibody is un-conjugated
(1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(85), (32), (18), (17), (13), (8), (8), (4), (4), (2), (1), (1)
Pubmed 1 reference available
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Product Details anti-TICAM1 Antibody

Target Details TICAM1 Application Details Handling References for anti-TICAM1 antibody (ABIN3021572) Images
Purification Affinity purification
Immunogen Recombinant protein of human TICAM1
Isotype IgG
Plasmids, Primers & others

Target Details TICAM1

Product Details anti-TICAM1 Antibody Application Details Handling References for anti-TICAM1 antibody (ABIN3021572) Images back to top
Antigen
Alternative Name TICAM1 (TICAM1 Antibody Abstract)
Background Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 AAs known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkappaB that normally maintains NF-kappaB inactivity by sequestering it in the cytoplasm. TRIF (also termed TICAM-1) is a TIR-domain adaptor protein described to activate NF-kappaB, IRF3 and trigger IFN-beta production. Studies using dominant negative forms of TRIF and siRNA targeting TRIF show that TRIF functions downstream of both TLR3 and TLR4 in response to dsRNA and LPS respectively. TRIF recruits TRAF6-TAK1-TAB2 to the receptor complex which leads to NF-kappaB activation. In addition, TRIF can trigger signaling of that lead to the induction of apoptosis.
Synonyms: TRIF, PRVTIRB, TICAM-1
Gene ID 148022
UniProt Q8IUC6
Pathways TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades

Application Details

Product Details anti-TICAM1 Antibody Target Details TICAM1 Handling References for anti-TICAM1 antibody (ABIN3021572) Images back to top
Application Notes Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Restrictions For Research Use only

Handling

Product Details anti-TICAM1 Antibody Target Details TICAM1 Application Details References for anti-TICAM1 antibody (ABIN3021572) Images back to top
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze / thaw cycles
Storage -20 °C/-80 °C

References for anti-TICAM1 antibody (ABIN3021572)

Product Details anti-TICAM1 Antibody Target Details TICAM1 Application Details Handling Images back to top
Product cited in:

Du, Qiao, Chen, Chen, Liu, Lin, Wang, Xie: "Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes." in: Frontiers in molecular neuroscience, Vol. 10, pp. 409, 2017 Method employed by authors: Western Blotting (WB)

Images

Product Details anti-TICAM1 Antibody Target Details TICAM1 Application Details Handling References for anti-TICAM1 antibody (ABIN3021572) back to top
Supplier Images
Western Blotting (WB) image for anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) antibody (ABIN3021572) anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) antibody
Western Blotting (WB) image for anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) antibody (ABIN3021572) Western blot analysis of extracts of various cell lines, using TICAM1 antibody.