anti-Mouse (Murine) TLR5 antibody for Immunofluorescence

Recommended TLR5 Antibody (supplied by: Log in to see )

Antigen
Toll-Like Receptor 5 (TLR5) Antibodies
  • SLEB1
  • TIL3
  • TLR-5
  • sleb1
  • til3
  • tlr-5
  • tlr5
  • toll like receptor 5
  • toll-like receptor 5
  • toll like receptor 5 L homeolog
  • toll-like receptor 5b
  • TLR5
  • Tlr5
  • tlr5.L
  • tlr-5
  • tlr5b
Epitope
C-Term
32
15
14
11
11
11
11
10
7
7
7
5
5
4
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
243
146
48
43
5
2
2
2
1
Host
Rabbit
166
93
4
Clonality
Polyclonal
Conjugate
This TLR5 antibody is un-conjugated
22
17
12
9
8
5
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
207
92
83
71
64
19
16
13
11
10
5
4
3
1
Supplier
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Catalog No. ABIN265142
$ 610.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
4 ABIN302879 IF IHC (p) WB Rabbit C-Term Log in to see Polyclonal 0
1 ABIN5555337 EIA IF WB Rabbit IgG C-Term Log in to see Polyclonal 0

General

Antigen Toll-Like Receptor 5 (TLR5) Antibodies
Epitope C-Term
(32), (15), (14), (11), (11), (11), (11), (10), (7), (7), (7), (5), (5), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(243), (146), (48), (43), (5), (2), (2), (2), (1)
Host Rabbit
(166), (93), (4)
Clonality
Polyclonal
Conjugate This TLR5 antibody is un-conjugated
(22), (17), (12), (9), (8), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (IF), Western Blotting (WB)
(207), (92), (83), (71), (64), (19), (16), (13), (11), (10), (5), (4), (3), (1)
Pubmed 5 references available
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Product Details anti-TLR5 Antibody

Target Details TLR5 Application Details Handling References for anti-TLR5 antibody (ABIN265142) Images
Specificity This antibody detects TLR5.
Purification Purified
Immunogen Peptide corresponding to 15 amino acids near the carboxy terminus of human TLR5
Isotype IgG
Plasmids, Primers & others

Target Details TLR5

Product Details anti-TLR5 Antibody Application Details Handling References for anti-TLR5 antibody (ABIN265142) Images back to top
Antigen
Alternative Name TLR5 (TLR5 Antibody Abstract)
Background Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-κB, leading to the activation of TNF-? and other cytokines (4). A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires' disease and demonstrates the importance of TLR5 in the innate immune response (5). Found in the membrane, TLR5 is hghly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis (6).Synonyms: TIL3, Toll-like receptor 5, Toll/interleukin-1 receptor-like protein 3
Gene ID 7100
NCBI Accession NP_003259
UniProt O60602
Pathways TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades

Application Details

Product Details anti-TLR5 Antibody Target Details TLR5 Handling References for anti-TLR5 antibody (ABIN265142) Images back to top
Application Notes Western Blot: 1-2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-TLR5 Antibody Target Details TLR5 Application Details References for anti-TLR5 antibody (ABIN265142) Images back to top
Buffer Phosphate buffered saline with 0.02 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C. Can be shipped at 2-8 °C.

References for anti-TLR5 antibody (ABIN265142)

Product Details anti-TLR5 Antibody Target Details TLR5 Application Details Handling Images back to top
Background publications

McGettrick, ONeill: "The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction." in: Molecular immunology, Vol. 41, Issue 6-7, pp. 577-82, 2004

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003

Hawn, Verbon, Lettinga, Zhao, Li, Laws, Skerrett, Beutler, Schroeder, Nachman, Ozinsky, Smith, Aderem: "A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease." in: The Journal of experimental medicine, Vol. 198, Issue 10, pp. 1563-72, 2003

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002

Hayashi, Smith, Ozinsky, Hawn, Yi, Goodlett, Eng, Akira, Underhill, Aderem: "The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5." in: Nature, Vol. 410, Issue 6832, pp. 1099-103, 2001

Images

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Supplier Images
 image for anti-Toll-Like Receptor 5 (TLR5) (C-Term) antibody (ABIN265142) anti-Toll-Like Receptor 5 (TLR5) (C-Term) antibody