anti-Human TLR6 antibody for Functional Studies

Recommended TLR6 Antibody (supplied by: Log in to see )

Antigen
Toll-Like Receptor 6 (TLR6) Antibodies
  • TLR1
  • TLR16
  • CD286
  • TLR-6
  • toll-like receptor 1 family member A
  • toll like receptor 6
  • toll-like receptor 6
  • TLR1A
  • TLR6
  • Tlr6
Reactivity
Human
192
68
10
3
3
2
1
1
Host
Mouse
132
73
14
Clonality
Monoclonal
Conjugate
This TLR6 antibody is un-conjugated
19
17
13
7
7
5
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
119
98
83
82
53
21
16
15
6
5
5
2
2
1
1
Supplier
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Catalog No. ABIN1106221
$ 368.50
Plus shipping costs $45.00

General

Antigen Toll-Like Receptor 6 (TLR6) Antibodies
Reactivity Human
(192), (68), (10), (3), (3), (2), (1), (1)
Host Mouse
(132), (73), (14)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TLR6 antibody is un-conjugated
(19), (17), (13), (7), (7), (5), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Functional Studies (Func), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
(119), (98), (83), (82), (53), (21), (16), (15), (6), (5), (5), (2), (2), (1), (1)
Pubmed 1 reference available
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Product Details anti-TLR6 Antibody

Target Details TLR6 Application Details Handling References for anti-TLR6 antibody (ABIN1106221) Images
Specificity This antibody detects TLR6.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein G
Clone TLR6-127
Isotype IgG1
Plasmids, Primers & others

Target Details TLR6

Product Details anti-TLR6 Antibody Application Details Handling References for anti-TLR6 antibody (ABIN1106221) Images back to top
Antigen
Alternative Name CD286 / TLR6 (TLR6 Antibody Abstract)
Background Toll-like receptors (TLRs) are highly conserved throughout evolution. They play an essential role in initiating the innate immune response against infectious pathogens. In Drosophila, toll is required for anti-fungal response, while the related 18-wheeler is involved in antibacterial defence. In humans, ten members of the TLR family protein (TLR1 to TLR10) have been identified. TLRs recognize a wide variety of pathogen-associated molecular patterns from bacteria, viruses, and fungi and elicit a wide array of antimicrobial responses. Among TLRs, TLR6 is expressed on the cell surface of monocytes, monocyte-derived immature dendritic cells (iDCs), and neutrophils, but not on B, T or natural killer (NK) cells. Human TLR6 is a 796-aa type l transmembrane protein that is 74 % identical with mouse. It contains an N-terminal signal peptide, 19 tandemly repeated extracellular leucine-rich motifs, and a cytoplasmic domain called Toll/IL-1R homology domain, as seen in other TLRs. TLR6 function has been studied mainly in mouse cells. Constitutive expression of TLR6 activates both the nuclear factor kappa-B (NFK-B) and Jun N-terminal kinase (JNK) pathways. Studies in human cells revealed that TLR6 and TLR2 colocalize at the plasma membrane of monocytes. Human TLR6 recognizes diacylated lipoprotein and peptidoglycan at the cell surface cooperatively with human TLR2. Thus, coexpression of TLR2 and TLR6 at the cell surface is crucial for recognition of diacylated lipopeptide and peptideoglycan and subsequent cellular activation in human cells.Synonyms: Toll-like receptor 6
Gene ID 10333
NCBI Accession NP_006059
UniProt Q9Y2C9
Pathways TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades

Application Details

Product Details anti-TLR6 Antibody Target Details TLR6 Handling References for anti-TLR6 antibody (ABIN1106221) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TLR6 Antibody Target Details TLR6 Application Details References for anti-TLR6 antibody (ABIN1106221) Images back to top
Concentration 0.1 mg/mL
Buffer PBS, 0.1 % bovine serum albumin
Storage 4 °C
Storage Comment Store at 2 - 8 °C.

References for anti-TLR6 antibody (ABIN1106221)

Product Details anti-TLR6 Antibody Target Details TLR6 Application Details Handling Images back to top
Background publications

Nakao, Funami, Kikkawa, Taniguchi, Nishiguchi, Fukumori, Seya, Matsumoto: "Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 3, pp. 1566-73, 2005