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Study demonstrates evidence of the constitutive expression of A20 in macrophages, its role in supporting the differentiation program, and the functional consequences of the zinc finger domains thereof.
A20 dimers bind linear ubiquitin to stabilize the Ripoptosome and potentiate its apoptosis-inducing activity.
At least in the subcutaneous fat of humans and mice, the levels of PGC (show PGC Proteins)-1a decrease during obesity, while its physical association with A20 increases.
Results suggest a clinicopathologic implication of A20 in progression of NKTL.
Studied effect of temperature on gene expression regulation by NF-kappabeta (show NFKB1 Proteins) on TNF alpha induced protein 3 (A20) transcription.
TNFAIP3 abnormality was less prevalent among intestinal diffuse large B-cell lymphomas with some discordancy between gene deletion and protein expression.
antidepressant treatment exerts anti-inflammatory effects, at least in part through increased expression of the TNFAIP3 gene
A20 regulates canonical wnt (show WNT2 Proteins)-signaling through an interaction with RIPK4 (show RIPK4 Proteins)
these results suggested that in human colorectal cancer cells, A20 may function to inhibit cancer progression via down-regulation of TNFalpha (show TNF Proteins)-induced chemokine (show CCL1 Proteins) production by suppression of ERK (show EPHB2 Proteins) signaling
A20 was significantly downregulated while p-p65 (RelA (show NFkBP65 Proteins)) significantly upregulated in the radioresistant nasopharyngeal carcinoma (NPC (show NPC1 Proteins))relative to radiosensitive NPCs, and miR (show MLXIP Proteins)-125b expression level was negatively associated with A20 expression level, whereas positively associated with p-p65 (RelA (show NFkBP65 Proteins)) level
T cell-specific A20 limited the expansion but reduced apoptosis and necroptosis of Listeria-specific CD8 (show CD8A Proteins)(+) T cells, resulting in an impaired pathogen control in primary but improved clearance in secondary infection.
study reveals a critical role of IL-17RC (show IL17RC Proteins) in maintaining baseline A20 production and a novel role of the IL-17RC (show IL17RC Proteins)-A20 axis in controlling JNK (show MAPK8 Proteins) isoform-dependent tumor-specific homeostatic proliferation.
The data demonstrate that miR (show MLXIP Proteins)-125b regulates nasopharyngeal carcinoma cell proliferation and apoptosis by targeting A20/NF-kappaB (show NFKB1 Proteins) signaling pathway, and miR (show MLXIP Proteins)-125b acts as oncogene (show RAB1A Proteins), whereas A20 functions as tumor suppressor.
Mice with A20 deficient B cells are prone to food allergy.
Tnfaip3, an anti-inflammatory gene, is located precisely underneath the linkage peak and contains two non-synonymous SNPs leading to conservative amino acid substitutions.
Hepatitis C virus core protein ligates gC1qR (show C1QBP Proteins) to induce A20 expression in macrophages via P38 (show CRK Proteins), JNK (show MAPK8 Proteins) and NF-kappaB (show NFKB1 Proteins) signaling pathways, which leads to a low-grade chronic inflammation during HCV infection.
These results suggest that Leishmania exploits A20 and UCP2 (show UCP2 Proteins) to impair inflammasome activation for disease propagation
A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1 (show SNAI1 Proteins).
Data show the characterization and deduced amino acid sequence analysis for A20 gene which expression increases in MDBK cells infected by BVDV-1. Also, regulatory regions for NF-kappaB (show NFKB1 Proteins) and Sp-1 (show SP1 Proteins) additionally to an ARE element for mRNA stability were detected
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.
tumor necrosis factor, alpha-induced protein 3
, OTU domain-containing protein 7C
, TNF alpha-induced protein 3
, putative DNA-binding protein A20
, tumor necrosis factor alpha-induced protein 3
, tumor necrosis factor inducible protein A20
, zinc finger protein A20
, tumor necrosis factor induced protein 3