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The results of this study confirmed that the A20 expression is reduced in whole blood of Multiple Sclerosis patients as compared to healthy control.
C/EBP beta (show CEBPB Proteins) LAP isoform expression was increased and LIP/TNFAIP3/TNIP1 (show TNIP1 Proteins) expression was decreased in systemic lupus erythematosus (SLE) patients. LAP expression was positively correlated with SLE disease activity; TNFAIP3 and TNIP1 (show TNIP1 Proteins) expression was negatively correlated with SLE disease activity.
A20 may have a role in the progression of chronic HBV infection
A20 overexpression inhibits hepatic stellate cell activation, which could be the mechanism for high A20 expression protected livers from fibrosis.
The data demonstrate that miR (show MLXIP Proteins)-125b regulates nasopharyngeal carcinoma cell proliferation and apoptosis by targeting A20/NF-kappaB (show NFKB1 Proteins) signaling pathway, and miR (show MLXIP Proteins)-125b acts as oncogene (show RAB1A Proteins), whereas A20 functions as tumor suppressor.
we demonstrate that a pathological reduction in TNFAIP3 levels induced NF-kappaB (show NFKB1 Proteins)/SMAD7 (show SMAD7 Proteins) pathway activation, causing a deficiency in MSCs in ITP (show ITPA Proteins) patients. The ability of ITP (show ITPA Proteins)-MSCs to support megakaryocytic differentiation and thrombopoiesis of CD34 (show CD34 Proteins)(+) cells was impaired.
miR (show MLXIP Proteins)-125b regulates differentiation and reprogramming of T cell glucose metabolism via targeting A20 in T cell acute lymphoblastic leukemia.
Review/Meta-analysis: TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis, especially among Caucasian populations.
In vitro deletion of A20 in B cells compromised the expression of IL10.
Low A20 expression is associated with hepatocellular carcinoma.
Mice with A20 deficient B cells are prone to food allergy.
Tnfaip3, an anti-inflammatory gene, is located precisely underneath the linkage peak and contains two non-synonymous SNPs leading to conservative amino acid substitutions.
Hepatitis C virus core protein ligates gC1qR (show C1QBP Proteins) to induce A20 expression in macrophages via P38 (show CRK Proteins), JNK (show MAPK8 Proteins) and NF-kappaB (show NFKB1 Proteins) signaling pathways, which leads to a low-grade chronic inflammation during HCV infection.
These results suggest that Leishmania exploits A20 and UCP2 (show UCP2 Proteins) to impair inflammasome activation for disease propagation
A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1 (show SNAI1 Proteins).
holding thymic production of natural Treg cells in check, A20 integrates Treg cell activity and increased effector T cell survival into an efficient CD4 (show CD4 Proteins)(+) T cell response
these studies establish A20 as a crucial hepatoprotective factor.
These results suggested that A20 is involved in regulating intracerebral hemorrhage-induced inflammatory injury in both the central and peripheral system
the ubiquitin-modifying enzyme TNFAIP3/A20, an upstream regulator of T cell receptor (TCR) signaling in T cells, is an essential cell-intrinsic regulator of Natural killer T differentiation.
Data show the characterization and deduced amino acid sequence analysis for A20 gene which expression increases in MDBK cells infected by BVDV-1. Also, regulatory regions for NF-kappaB (show NFKB1 Proteins) and Sp-1 (show SP1 Proteins) additionally to an ARE element for mRNA stability were detected
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.
tumor necrosis factor, alpha-induced protein 3
, OTU domain-containing protein 7C
, TNF alpha-induced protein 3
, putative DNA-binding protein A20
, tumor necrosis factor alpha-induced protein 3
, tumor necrosis factor inducible protein A20
, zinc finger protein A20
, tumor necrosis factor induced protein 3