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IL-6 likely up-regulates IRP1 and DMT1 expression and down-regulates FPN1 expression in BV2 microglial cells through JNK signaling pathways
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Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1, enzymes involved in the TCA cycle, were elevated.
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The Irp1-/- mice develop polycythemia and pulmonary hypertension, and suggesting that Irp1 plays an essential role in erythropoiesis and in the pulmonary and cardiovascular systems.
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IRP1 and IRP2 mutant mice rapidly succumb to systemic infection with Salmonella Typhimurium, a pathogenic bacterium that multiplies within macrophages, with increased bacterial burdens in liver and spleen.
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results uncover an unexpected protective role of IRP1 in pathological conditions associated with altered Fe-S metabolism
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Aco1 KD in fully differentiated 3T3-L1 adipocytes decreased lipogenic, Idh1, Adipoq, and Glut4 gene expression.
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impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1(gt/gt) cells results in elevated IRP1 RNA-binding that attenuates ALAS2 mRNA translation and protoporphyrin accumulation
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Data indicate that JTR-009, a benzimidazole, operated by preventing iron-regulatory protein-1 (IRP1) from binding to the iron-responsive element (IRE) in APP mRNA.
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Human ACO1 is a moonlighting protein that has both aconitase enzyme activity as well as an mRNA binding function.
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Aco1 is a moonlighting protein that has aconitase activity as well as mRNA binding ability.
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IRP1 is the principal regulator of HIF2alpha mRNA translation
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Irp1 deletion enhanced HIF2alpha protein expression in kidneys of Irp1(-/-) mice.
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These results uncover separable physiological roles of each IRP and identify IRP1 as a therapeutic target for manipulating HIF-2alpha action in hematologic, oncologic, and other disorders.
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The RNA-binding and aconitase forms of IRP-1 can undergo interconversion dependent on the density of cells growing in culture.
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aconitase functions as a licensing factor in ERK-dependent proliferation and differentiation, thereby providing a regulatory input for iron in EPO-dependent erythropoiesis.
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A wide network of mRNAs and proteins with iron-dependent regulation, IRP-dependent regulation, or both.
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Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.
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Mice lacking both IRP1 in their hepatocytes suffer from mitochondrial iron deficiency and dysfunction associated with alterations of the ISC and heme biosynthetic pathways, leading to liver failure and death.
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Iron regulatory protein-1 (Irp1)/aconitase activities studied in macrophages grown under control conditions or subjected to iron starvation or supplementation show that Irp1 is activated by direct disassembly of the Fe-S cluster of cytoplasmic aconitase.
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A comparative study of the roles of iron regulatory proteins 1 and 2 in regulating iron metabolism.