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anti-Mouse (Murine) Aconitase 1 Antibodies:
anti-Human Aconitase 1 Antibodies:
anti-Rat (Rattus) Aconitase 1 Antibodies:
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Human Polyclonal Aconitase 1 Primary Antibody for IP, WB - ABIN947527
Rupani, Connell: Transferrin receptor mRNA interactions contributing to iron homeostasis. in RNA (New York, N.Y.) 2016
Arabidopsis thaliana Polyclonal Aconitase 1 Primary Antibody for WB - ABIN488534
Bernard, Cheng, Zhao, Balk: An allelic mutant series of ATM3 reveals its key role in the biogenesis of cytosolic iron-sulfur proteins in Arabidopsis. in Plant physiology 2009
Show all 4 Pubmed References
Human Monoclonal Aconitase 1 Primary Antibody for IP, ELISA - ABIN559748
Reuter, Reiermann, Wörner, Schröter, Edemir, Buck, Henning, Peter-Katalinic, Vollenbröker, Amann, Pavenstädt, Schlatter, Gabriëls: IF/TA-related metabolic changes--proteome analysis of rat renal allografts. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2010
Iron increases turnover of ACO1 in kidney cells, while increasing aconitase (show ACO2 Antibodies) activity, suggesting that the apoprotein (show APOE Antibodies) (aconitase (show ACO2 Antibodies)-inactive) form is not exclusively responsible for turnover.
IL-6 (show IL6 Antibodies) likely up-regulates IRP1 and DMT1 (show SLC11A2 Antibodies) expression and down-regulates FPN1 (show SLC40A1 Antibodies) expression in BV2 (show DNAH9 Antibodies) microglial cells through JNK (show MAPK8 Antibodies) signaling pathways
Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 (show IDH1 Antibodies) and Aco1, enzymes involved in the TCA cycle, were elevated.
The Irp1-/- mice develop polycythemia and pulmonary hypertension, and suggesting that Irp1 plays an essential role in erythropoiesis and in the pulmonary and cardiovascular systems.
IRP1 and IRP2 (show IREB2 Antibodies) mutant mice rapidly succumb to systemic infection with Salmonella Typhimurium, a pathogenic bacterium that multiplies within macrophages, with increased bacterial burdens in liver and spleen.
results uncover an unexpected protective role of IRP1 in pathological conditions associated with altered Fe-S metabolism
Aco1 KD in fully differentiated 3T3-L1 adipocytes decreased lipogenic, Idh1, Adipoq, and Glut4 gene expression.
impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1 (show SLC25A37 Antibodies)(gt/gt (show FABP6 Antibodies)) cells results in elevated IRP1 RNA-binding that attenuates ALAS2 (show ALAS2 Antibodies) mRNA translation and protoporphyrin accumulation
Data indicate that JTR-009, a benzimidazole, operated by preventing iron-regulatory protein-1 (IRP1) from binding to the iron-responsive element (IRE) in APP (show APP Antibodies) mRNA.
Human ACO1 is a moonlighting protein that has both aco (show ACO2 Antibodies)nitase enzyme activity as well as an mRNA binding function.
Aco1 is a moonlighting protein that has aconitase (show ACO2 Antibodies) activity as well as mRNA binding ability.
regulatory circuit involving FBXL5 (show FBXL5 Antibodies) and CIA (show ASF1A Antibodies) acts through both IRPs to control iron metabolism and promote optimal cell growth
Data suggest that Fe-S cluster of IRP1 plays role in sensing/regulating cellular iron homeostasis; IRP1 alternates between function as cytosolic aconitase [which contains Fe(4)-S(4) cluster in active-site cleft] and function as apoenzyme [which lacks Fe-S cluster] that binds to iron response element stem-loop structures present in several iron regulatory protein transcripts. [REVIEW]
The SNP rs7874815 in the ACO1 gene was strongly associated with survival in pancreatic cancer.
Our results confirm the observation that mitoNEET (show CISD1 Antibodies) is important in transferring the iron sulfur clusters to the cytosolic aconitase in living cells and the His-87 ligand in mitoNEET (show CISD1 Antibodies) plays important role in this process.
Data show that IRP1 suppressed TfR1/DMT1 (+IRE) expression, limited the cellular iron content and decreased lactate dehydrogenase (LDH) release induced by hypoxia.
These in vitro studies suggest that human GLRX3 (show GLRX3 Antibodies) is important for cytosolic Fe-S protein (show CDSN Antibodies) maturation.
SIRT3 (show SIRT3 Antibodies) overexpression decreases TfR1 (show TFRC Antibodies) expression by inhibiting IRP1 and represses proliferation in pancreatic cancer cells.
ACO1 gene expression was positively associated with adipogenic markers in subcutaneous and visceral adipose tissue.
ACO1 genetic variation is associated with neuropathic pain and pain severity in HIV-infected patients on antiretroviral therapy
MitoNEET (show CISD1 Antibodies) governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/IRP1.
Even though the base-specific RNA-binding residues are not part of the aconitase active site, their substitutions can affect the aconitase activity of holo-IRP1, positively or negatively.
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
aconitase 1, soluble
, cytoplasmic aconitate hydratase
, iron regulatory protein 1
, aconitase 1-like
, 1-Aminocyclopropane-1-carboxylic acid oxidase
, ACC oxidase 1
, ethylene-forming enzyme
, protein pTOM 13
, IRE-BP 1
, citrate hydro-lyase
, cytoplasmic aconitase
, iron-responsive element-binding protein 1
, IRE-binding protein 1
, Iron responsive element binding protein
, aconitate hydratase, cytoplasmic
, ferritin repressor protein
, iron-responsive element binding protein 1