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proximal promoter region contains cis-acting elements required for expression in cancer cells
These studies show a Na(+)- and HCO(3)(-)-independent pH(cyt) regulatory mechanism in HLMVE cells that is mediated by pmV-ATPases.
there is an important role for physical association between aldolase and the A, B and E subunits of V-ATPase in the regulation of the proton pump
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.
H(+)-transporting two-sector ATPase, subunit F
, V-ATPase 21 kDa proteolipid subunit
, V-ATPase subunit c''
, V-type proton ATPase 21 kDa proteolipid subunit
, vacuolar ATP synthase 21 kDa proteolipid subunit
, vacuolar proton pump 21 kDa proteolipid subunit
, vacuolar proton pump, 21 kDa subunit
, 23 kDa subunit of V-ATPase
, ATPase, H+ transporting, V0 subunit B
, ATPase, H+ transporting, lysosomal (vacuolar proton pump)
, ATPase, H+ transporting, lysosomal 21kDa, V0 subunit B
, lysosomal 21kDa
, ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b