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Mouse (Murine) Ferritin Mitochondrial Protein expressed in Escherichia coli (E. coli) - ABIN2121023
Inokura, Fujiwara, Saito, Iino, Hatta, Okitsu, Fukuhara, Onishi, Ishizawa, Shimoda, Harigae: Impact of TET2 deficiency on iron metabolism in erythroblasts. in Experimental hematology 2017
Lack of mitochondrial ferritin aggravated neurological deficits via enhancing oxidative stress in a traumatic brain injury murine model.
Age-related increase is found in FtMt and hypoxia-inducible factor-1a (HIF-1a (show HIF1A Proteins)) in murine retinal pigment epithelium (RPE (show RPE Proteins)).HIF-1alpha (show HIF1A Proteins) stabilization reduced the protein level of the mature, functional form of mitochondrial ferritin.
ferritin H not only responds to changes in tissue iron (its classic role), but can actively regulate overall tissue iron balance
mitochondrial ferritin has a role in tumor growth inhibition by cytosolic iron deprivation
PIAS3 (show PIAS3 Proteins) is a new regulator of ATF1 (show AFT1 Proteins) that regulates the ARE-mediated transcription of the ferritin H gene
ionomycin-mediated induction of ferritin H may occur in an NFAT (show NFATC1 Proteins)-independent manner but through post-transcriptional stabilization of the ferritin H mRNA.
ferritin H transcription is activated by rotenone via an oxidative stress-mediated pathway leading to antioxidant-responsive element activation
Our results provide evidence that the iron storage function of ferritin (show FTL Proteins) plays a major role in preventing iron-mediated cell and tissue damage.
The expression of FTMT appears regulated by a complex mechanism involving epigenetic events and interplay between transcription factors.
Study characterized a new human FtMt antibody, and with it created the first map of FtMt immunoreactivity in a monkey brainstem. This showed the widespread distribution of FtMt in various brainstem regions and co-localization with catecholaminergic neurons.
experimental overexpression of FTMT may modify mitochondrial iron availability and lead to ineffective erythropoiesis
FtMt mutation may determine a condition similar to haploinsufficiency resulting in a reduced protection from iron-dependent oxidative stress in mitochondria
Stat5 (show STAT5A Proteins)-dependent transcriptional regulation is displaced by strong cytosolic iron starvation status induced by mitochondrial ferritin.
higher protein levels in prostate cancer cells expressing a dominant negative mutant of p66Shc (show SHC1 Proteins)
MtF is involved in the pathology of Alzheimer's disease and may play a neuroprotective role against oxidative stress
MtF expression is downregulated during ATRA-induced K562 cell differentiation, with concomitant downregulation of TfR1 (show TFRC Proteins) and upregulation of Fn.
The analysis suggests that sequence variations in the coding region of FtMt are not involved in the development of myelodysplastic syndromes and Parkinson's disease.
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).
, ferritin H
, ferritin heavy chain 3
, ferritin, mitochondrial
, ferritin H subunit
, ferritin heavy chain, oocyte isoform