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Haptoglobin Proteins

(Haptoglobin (HP))

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

recommended

Haptoglobin Protein (HP) (AA 145-405) (His tag) (ABIN7123252)

HP Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

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recommended

Haptoglobin Protein (HP) (AA 1-281) (GST tag) (ABIN1307018)

HP Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

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recommended

Haptoglobin Protein (HP) (AA 19-101) (His tag) (ABIN3123026)

Crystallography grade HP Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys

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Haptoglobin Proteins by Grade

Find Haptoglobin Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

Haptoglobin Proteins by Origin

Find Haptoglobin Proteins for a variety of species such as anti-Human Haptoglobin, anti-Mouse Haptoglobin, anti-Rat Haptoglobin. The species listed below are among those available. Click on a link to go to the corresponding products.

Haptoglobin Proteins by Source

Here you will find Haptoglobin Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

Haptoglobin Proteins by Protein Type

Here you can find Haptoglobin Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

Haptoglobin Proteins by Application

Find Haptoglobin Proteins validated for a specific application such as ELISA, SDS, WB, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular Haptoglobin Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

Haptoglobin Protein (HP) (AA 145-405) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7123252

Quantity 50 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 1-281) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1307018

Quantity 10 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 19-101) (His tag)

Reactivity Mouse

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN3123026

Quantity 1 mg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 162-406) (His tag)

Reactivity Human

Source Insect Cells

Validations

Cat. No. ABIN3081618

Quantity 1 mg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 19-160) (His tag)

Reactivity Human

Source Insect Cells

Validations

Cat. No. ABIN3081617

Quantity 1 mg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 19-406) (His tag)

Reactivity Human

Source Insect Cells

Validations

Cat. No. ABIN3092992

Quantity 1 mg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 19-347) (His tag)

Reactivity Mouse

Source Insect Cells

Validations

Cat. No. ABIN3123027

Quantity 1 mg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 103-347) (His tag)

Reactivity Mouse

Source Insect Cells

Validations

Cat. No. ABIN3123025

Quantity 1 mg

Datasheet Datasheet

Haptoglobin Protein (HP) (Phenotype 1-1)

Reactivity Human

Source Human

Validations

Cat. No. ABIN3119693

Quantity 1 mg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 118-281) (His tag)

Reactivity Mouse

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7505808

Quantity 100 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 19-406) (His tag)

Reactivity Human

Source Human Cells

Validations

Cat. No. ABIN1945383

Quantity 50 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 19-160, AA 162-406) (His tag)

Reactivity Human

Source Human Cells

Validations

Cat. No. ABIN7318556

Quantity 50 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 145-406) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7318557

Quantity 50 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 44-157) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7392218

Quantity 100 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 168-319) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7402730

Quantity 100 μg

Datasheet Datasheet

Latest Publications for our Haptoglobin Proteins

Pirschel, Mestekemper, Wissuwa, Krieg, Kröller, Daniel, Gunzer, Tolosano, Bauer, Amann, Heinemann, Coldewey: "Divergent roles of haptoglobin and hemopexin deficiency for disease progression of Shiga-toxin-induced hemolytic-uremic syndrome in mice." in: Kidney international, (2022) (PubMed).

Eshbach, Kaur, Rbaibi, Tejero, Weisz: "Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease." in: American journal of physiology. Cell physiology, Vol. 312, Issue 6, pp. C733-C740, (2017) (PubMed).

Kozlik, Goldman, Sanda: "Study of structure-dependent chromatographic behavior of glycopeptides using reversed phase nanoLC." in: Electrophoresis, Vol. 38, Issue 17, pp. 2193-2199, (2017) (PubMed).

Sakamoto, Kim, Hara, Kamada, Caballero-Flores, Tolosano, Soares, Puente, Inohara, Núñez: "IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections." in: Science immunology, Vol. 2, Issue 8, (2017) (PubMed).

Fatunmbi, Abzalimov, Savinov, Gershenson, Kaltashov: "Interactions of Haptoglobin with Monomeric Globin Species: Insights from Molecular Modeling and Native Electrospray Ionization Mass Spectrometry." in: Biochemistry, Vol. 55, Issue 12, pp. 1918-28, (2016) (PubMed).

Chen-Roetling, Regan: "Haptoglobin increases the vulnerability of CD163-expressing neurons to hemoglobin." in: Journal of neurochemistry, Vol. 139, Issue 4, pp. 586-595, (2016) (PubMed).

Almeida, Souza, Leonardo, Costa, Werneck, Covas, Costa, Conran: "Acute hemolytic vascular inflammatory processes are prevented by nitric oxide replacement or a single dose of hydroxyurea." in: Blood, Vol. 126, Issue 6, pp. 711-20, (2015) (PubMed).

Zapotoczna, Heilbronner, Speziale, Foster: "Iron-regulated surface determinant (Isd) proteins of Staphylococcus lugdunensis." in: Journal of bacteriology, Vol. 194, Issue 23, pp. 6453-67, (2012) (PubMed).

Aliases for Haptoglobin Proteins

haptoglobin (HP) Proteins
haptoglobin (hp) Proteins
haptoglobin (Hp) Proteins
haptoglobin-like (LOC479668) Proteins
haptoglobin (LOC101102413) Proteins
BP Proteins
HP Proteins
HP-1 Proteins
HP2ALPHA2 Proteins
HPA1S Proteins
HPR Proteins
wu:fb64e01 Proteins
Zonulin Proteins

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Haptoglobin Proteins by Grade

Haptoglobin Proteins by Origin

Haptoglobin Proteins by Source

Haptoglobin Proteins by Protein Type

Haptoglobin Proteins by Application

Popular Haptoglobin Proteins

Latest Publications for our Haptoglobin Proteins

Aliases for Haptoglobin Proteins

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