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Results suggest that soybean HO-1 gene expression is not epigenetically regulated. Moreover, the low level of HO-1 promoter methylation suggests that this antioxidant enzyme can rapidly respond to environmental stress.
study evaluated the time-course of HO-1 and catalase (show CAT Proteins) gene expressions in nodules and roots of soybean plants subjected to cadmium treatment
Data suggest expression of hsp32 is up-regulated in kidney epithelial cells upon in vitro exposure to heavy metal water pollutants (Cd, As) or proteasomal inhibitors (MG132, withaferin A, celastrol); heat shock may be synergistic factor.
this study provides a better understanding of the role of the HO-1/Carbon monoxide system in controlling heart function in lower vertebrates.
The induced expression of HO-1 by fenofibrate appeared to be essential for mediating the protective effects of fenofibrate, as the inhibition of HO-1 activity significantly diminished the protective effects of fenofibrate against the GM-mediated death of sensory hair cells in cochlea
Suggest that Gata-1 (show GATA1 Proteins) and Nrf2a (show NFE2L2 Proteins) play differential roles in regulating the heme degradation enzymes hmox1a/bvra (show BLVRA Proteins)/bvrb (show BLVRB Proteins) during an early developmental period of heightened cellular stress.
Bach1 (show BACH1 Proteins) regulates the liver specificity and transience of the Nrf2a (show NFE2L2 Proteins)-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Proteins) inhibition based on its level in each tissue.
Data indicate that Heme oxygenase 1 (HY1) functioned negatively and acted upstream of ABSCISIC ACID-INSENSITIVE4 (ABI4) in drought signaling.
HY1 confers cadmium tolerance by decreasing nitric oxide production and improving iron homeostasis.
Data indicate that AtHO1 (HY1; heme oxygenase-1)-overexpressing plants generated more NO, whereas knock-down of AtHO1 expression reduced the level of nitric oxide (NO) in plants.
HY1 mutant exhibited progressive salt hypersensitivity.
Disrupting the binding of the AtHBP5 to haem oxygenase 1 (HY1) leads to oxidative stress.
Mutation of HY1 causes UV-C hypersensitivity by impairing carotenoid and flavonoid biosynthesis and the down-regulation of antioxidant defence.
HY1 and HY5 additively regulate the expression of light regulated genes and accumulation of chlorophyll and anthocyanin during early seedling development.
HY1 (Heme oxygenase 1) plays an important role in salt acclimation.
all members of the HO1 subfamily (HY1, HO3 and HO4) are active monomeric HOs and can convert haem to BV IXalpha using spinach Fd (ferredoxin) as an electron donor
HO2 (show HMOX2 Proteins) has an activity high enough to substitute for HO1 under aerobic conditions.
HO-1 might be a potential marker for prediction of ovarian cancer prognosis and a target for ovarian cancer treatment
HO-1 was an important cellular factor against Dengue virus replication.
our results demonstrate that Pc-induced expression of HO-1 is mediated by the PKCA (show PKCa Proteins)-Nrf-2 (show GABPA Proteins)/HO-1 pathway, and inhibits UVB-induced apoptotic cell death in primary skin cells.
HO-1 regulates macrophage activation via the SIRT1 (show SIRT1 Proteins)-p53 (show TP53 Proteins) signaling network and regulates hepatocellular death in liver ischemia-reperfusion injury.
In light of a pivotal role of NRF2 (show GABPA Proteins) and BACH1 (show BACH1 Proteins) in response to oxidative stress and regulation of HO-1, we examined if smoke-induced HO-1 expression is modulated through the NRF2 (show GABPA Proteins)/BACH1 (show BACH1 Proteins) axis. We demonstrated that smoke causes significant nuclear translocation of NRF2 (show GABPA Proteins), but only a slight decrease in nuclear BACH1 (show BACH1 Proteins).
downregulation of HO-1 gene expression in patients with inflammatory bowel disease.
This study demonstrated that HO-1 plays a vital role in the development of gastric cancer and may serve as a therapeutic target of this type of cancer
Overexpression of HO-1 inhibited the increase in nucleus pulposus cell apoptosis after IL-1beta (show IL1B Proteins) treatment and simultaneously inhibited the expression of p-P65 (show GORASP1 Proteins).
We also found a subset of prostate cancer patient-derived xenografts and prostate cancer patient samples with mild HO-1 and low Gal-1 (show LGALS1 Proteins) expression levels. These results highlight a novel function of a human-used drug as a means of boosting the antitumor response
Our data suggest that HO-1 exerts its inhibitory effect on Th17 cell differentiation by directly associating and blocking STAT3 (show STAT3 Proteins) phosphorylation. We speculate that hemin may be a potential therapeutic candidate for the treatment of other types of immune and pulmonary inflammatory-related diseases.
These results provide a unique insight into the molecular mechanisms underlying the antiviral effects of the stress-responsive protein HO-1 during Porcine reproductive and respiratory syndrome virus infection.
findings collectively suggest that miR (show MYLIP Proteins)-506 acts as a tumor suppressor via regulation of ROCK1 (show ROCK1 Proteins) expression and may thus be a promising therapeutic target for HCC (show FAM126A Proteins)
Exogenous administration of CO exacerbated allergic symptoms, resulting in higher levels of both CO and heme oxygenase-1 expression, and a further reduction in H2S levels and CSE expression.
Down-regulation of HO-1 is associated with pulmonary arterial hypertension and right ventricular failure.
The study revealed the involvement of HO-1 in classical swine fever virus proliferation.
The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.
Glutamate (show GRIN2C Proteins) regulates Ca2 (show CA2 Proteins)+ signals in smooth muscle cells of newborn piglet brain slice arterioles through astrocyte- and heme oxygenase-dependent mechanisms.
obalt protoporphyrin prevents postictal cerebral vascular dysfunction by upregulating HO-1.
Data demonstrate that lipopolysaccharides evoke a heat shock response, with an increase heat shock proteins 70 and Hsp32) and of VEGF (show VEGFA Proteins), a specific endothelial cell growth factor (show FGF1 Proteins).
Interaction of soluble factors in plasma possibly generated during PICSO are not responsible for upregulation of HO-1 and VEGF (show VEGFA Proteins) mRNA.
the data were consistent with HO-1 acting as an anti-viral factor and these findings suggested that induction of HO-1 may be a useful prevention and treatment strategy against BVDV infection.
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 (show NFE2L2 Proteins) expression early in the course of infection, which results in increased expression of HO-1 within these cells.
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: regulation of HO-1 gene expression in aortic endothelial cells by advanced glycation end products
Sickle blood increases endothelial heme oxygenase activity.
data provide evidence for the involvement of the thioredoxin/thioredoxin (show TXN Proteins) receptor system, in the regulation of haem oxygenase-1 expression in aortic endothelial cells during pro-oxidant challenge
Heme oxygenase-1 induction modulates hypoxic pulmonary vasoconstriction through upregulation of ecSOD/SOD3 (show SOD3 Proteins).
Genetic Hmox1 partial deficiency is sufficient to sensitize mice to the development of diabetic glomerular microvascular lesions. HO-1 exerts antioxidant effects in the kidney during diabetes mellitus. These have protective effects on the development of glomerular endothelial injury.
Inhibition of miR (show MLXIP Proteins)-92a attenuates oxidative stress and improves endothelial function through enhancing HO-1 expression and activity in db/db (show LEPR Proteins) mouse aortas
n-propargyl caffeamide (PACA) attenuated LPS (show TLR4 Proteins)-induced NF-kB activation while activated Nrf2 (show NFE2L2 Proteins)/HO-1 pathway. HO-1 inhibitor SnPP attenuated the effects of PACA on iNOS (show NOS2 Proteins) expression in LPS (show TLR4 Proteins)-challenged macrophages, possibly by regulating the cross-talk between HO-1 and NF-kB pathways.
Ablation of adipose tissue-HO-1 abridged PGC1 expression promoted mitochondrial dysfunction and contributed to an increase of pro-inflammatory visceral fat and abrogated beige-cell like phenotype.
These results suggested that schisandrin A has a protective effect against LPS (show TLR4 Proteins)-induced inflammatory and oxidative responses in RAW 264.7 cells by inhibiting the NF-kappaB (show NFKB1 Proteins), MAPK (show MAPK1 Proteins) and PI3K/Akt (show AKT1 Proteins) pathways; these effects are mediated, at least in part, by the activation of the Nrf2 (show NFE2L2 Proteins)/HO-1 pathway
Rosiglitazone Regulates TLR4 (show TLR4 Proteins) and Rescues HO-1 and NRF2 (show NFE2L2 Proteins) Expression in Myometrial and Decidual Macrophages in Inflammation-Induced Preterm Birth.
this study shows that induction of heme oxygenas-1 attenuates NLRP3 (show NLRP3 Proteins) inflammasome activation in lipopolysaccharide-induced mastitis in mice
DADLE was able to significantly improve hepatic I/R injury in mice, and the specific mechanism may be associated with the Nrf2 (show NFE2L2 Proteins)/HO1 signaling pathway.
These data demonstrate that 2% H2 inhalation may be a promising therapeutic strategy for intestinal injuries caused by severe sepsis through the regulation of HO-1 and HMGB1 (show HMGB1 Proteins) release. In addition, Nrf2 (show NFE2L2 Proteins) plays a key role in the protective effects of H2 against intestinal damage in this disease.
HO-1 role in the feedback response to blood carbon monoxide depletion
The expression of oxidative stress markers were upregulated after light exposure but attenuated by cyanidin-3-glucoside and ferulic acid, which may be attributed to the elevated secretion and expression of heme oxygenase (HO-1) and nuclear factor erythroid-2 related factor 2 (Nrf2 (show NFE2L2 Proteins)).
Kidneys from circulation-restricted fetuses showed reduced heme oxygenase-1 mRNA.
Ligustrazine injection possesses notable protective effects on ischemia/reperfusion injury in rabbits by increasing the expression of HO-1 in lung.
Results add new evidence for the importance of HO-1 in the genesis and development of atherosclerosis and provide several possible mechanisms underlying the anti-atherosclerosis effects of HO-1
the effect of HO-1 on the progression and stabilization of vulnerable plaques and the possible mechanism
Heme-L-lysinate could attenuate atherosclerotic progression through upregulating HO-1 and HSP70 (show HSP70 Proteins) expression and increasing CO production.
These results suggest that HO-1 is important in limiting in-stent stenosis and can be regarded as a new therapeutic target.
Statins showed anti-atherosclerotic effects mediated by HO-1/eNOS (show NOS3 Proteins), restoring the [NO]/[ONOO(-)] imbalance and reducing lipid peroxidation.
HO-1/CO system was activated and may be one of the protective signal pathway during pulmonary ischemia-reperfusion injury in rabbits.
HO-1 contributes to vascular repair by increasing circulating endothelial progenitor cells (EPCs) derived from the bone marrow.
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.
heme oxygenase (decycling) 1
, heme oxygenase 1
, heme oxygenase
, Heme oxygenase
, heat shock protein, 32-kD
, heat shock protein 32
, heme oxygenase (decyclizing) 1
, P32 protein
, heme oxygenase-1