anti-Rat (Rattus) Prion Protein 2 (Dublet) antibody for Western Blotting

Recommended Prion Protein 2 (Dublet) Antibody (supplied by: Log in to see )

Antigen
Prion Protein 2 (Dublet) (PRND) Antibodies
  • PRND
  • DOPPEL
  • DPL
  • PrPLP
  • dJ1068H6.4
  • dpl
  • AI450264
  • Dpl
  • doppel
  • prion like protein doppel
  • PRND
  • Prnd
Reactivity
Human, Mouse (Murine), Rat (Rattus)
26
19
14
Host
Rabbit
26
Clonality
Polyclonal
Conjugate
HRP
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
13
12
8
4
3
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Catalog No. ABIN1410896
$ 405.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1393003 IHC (p) WB Biotin Rabbit IgG Log in to see Polyclonal 0
1 ABIN1387270 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal 0

General

Antigen Prion Protein 2 (Dublet) (PRND) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(26), (19), (14)
Host Rabbit
(26)
Clonality
Polyclonal
Conjugate HRP
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(13), (12), (8), (4), (3)
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Product details

Target Details Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Doppel
Isotype IgG

Target Details

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Antigen
Alternative Name Doppel/Dpl (PRND Antibody Abstract)
Background

Prion diseases or transmissible spongiform encephalopathies (TSEs) are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Infectious PrPSc is highly expressed in the brain of animals affected by TSEs, including scrapie in sheep, BSE in cattle, and Cruetzfeldt-Jacob disease in humans. The PRND gene locus, located on human chromosome 20p, encodes for the doppel protein (Dpl), which exhibits approximately 25 % sequence homology with PrP. Dpl is characterized by an alpha-helical conformation, intramolecular disulfide bonds, and two N-linked oligosaccharides, and it is presented on the cell surface by a glycosylphosphatidylinositol anchor. Dpl is highly expressed in adult testis and heart and is detectable in the brain of neonatal mice. Dpl does not appear to contribute to prion disease progression, but ectopic expression of Dpl is implicated in neuronal degeneration of ataxic PRP-deficient mice. Dpl is also thought to play a role in angiogenesis, specifically maturation of the blood-brain barrier.

Synonyms: DPL, Dublet, MGC41841, Prion gene complex downstream, Prion like protein doppel, Prion protein 2 dublet, Prion protein 2, Prion-like protein doppel, PRND, PRND_HUMAN, PrPLP.

Pathways Transition Metal Ion Homeostasis

Application Details

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Application Notes WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only

Handling

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Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Preservative Gentamicin sulfate
Precaution of Use This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months