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Rat (Rattus) Polyclonal Slc30a3 Primary Antibody for ICC, IP - ABIN1742411
Choi, Kim, Kim, Lee, Lee, Kho, Sohn, Suh: Zinc plus cyclo-(His-Pro) promotes hippocampal neurogenesis in rats. in Neuroscience 2016
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Rat (Rattus) Monoclonal Slc30a3 Primary Antibody for ICC, IP - ABIN1742409
Rafalo, Zadrozna, Nowak, Kotarska, Wiatrowska, Pochwat, Sowa-Kucma, Misztak, Nowak, Szewczyk: The level of the zinc homeostasis regulating proteins in the brain of rats subjected to olfactory bulbectomy model of depression. in Progress in neuro-psychopharmacology & biological psychiatry 2016
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Human Polyclonal Slc30a3 Primary Antibody for ICC, IHC - ABIN1742412
Nakahara, Miyake, Tajinda, Ito: Mossy fiber mis-pathfinding and semaphorin reduction in the hippocampus of α-CaMKII hKO mice. in Neuroscience letters 2015
Rat (Rattus) Polyclonal Slc30a3 Primary Antibody for ICC, IP - ABIN1742413
Maisano, Litvina, Tagliatela, Aaron, Grabel, Naegele: Differentiation and functional incorporation of embryonic stem cell-derived GABAergic interneurons in the dentate gyrus of mice with temporal lobe epilepsy. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
ZNT3 was only detected in human beta-cells, but not in mouse beta-cells.
SNPs in the SLC30A3 gene and adjacent region are associated with schizophrenia in female but not male cases.
There was a significant decreased in protein levels of ZnT3 in the prefrontal cortex in Major depression disorder, relative to control subjects.
The level of ERK1/2 phosphorylation was significantly increased by tunicamycin treatment in control cells, not in SLC30A3 knockdown cells. The ERK1/2 pathway is thought to have an association with defensive effects of SLC30A3 on cellular stress such as ER stress.
ZNT3 and ZNT8 (known to regulate insulin secretion) have opposite effects on insulin synthesis and secretion possibly by a transcriptional co-regulation since mRNA expression of ZNT3 was inversely correlated to ZNT8 and ZNT3 over-expression reduced insulin synthesis and secretion.
An association was found between reduced ZnT3 in the prefrontal cortex and cognitive impairment in patients with either dementia with Lewy bodies or Parkinson's disease dementia.
SNPs in SLC30A3 show a gender-specific association with schizophrenia in an East UK cohort.
this study provides the first evidence of a role for zinc in depression in people with dementia.
The results of this study suggested that ZnT3 protein levels are decreased in the spinal cords of sporadic ALS patients.
AIDL cells exhibited a lower expression of zinc transporter 1 (ZnT1) and higher expression of ZnT3 than LNCaP cells.
hZnT-3 is expressed at low levels in leukocytes.
Data show that ZNT3 is extensively present in the Abeta-positive plaques in the cortex of human AD brains.
SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity
ZnT3-/- mice showed reduced colchicine-induced dentate granule cell death.
the ZnT3 null state removed synaptic zinc, it rather increased free zinc in the cytosol of brain cells, which appeared to increase MMP-9 activity and BDNF levels. The present results suggest that zinc dyshomeostasis during the critical period of brain development may be a possible contributing mechanism for ASD.
Study showed a behavioral phenotype specifically for female ZnT3 knockout (KO) mice. Comparing results to previous studies, it appears that there may be sex-specific effects of eliminating ZnT3. Female ZnT3 KO mice exhibit abnormalities in locomotion and at skilled motor learning, but study was unable to detect spatial or fear learning deficits previously described in male ZnT3 KO mice.
Regarding rs11126936, the serum zinc concentration was lower in CC homozygotes (0.75 +/- 0.31 mg/L) than in A carriers (0.89 +/- 0.28 mg/L, P = .016).
ZnT3 null mice lack the transporter responsible for stocking synaptic vesicles, although they do have a zinc veneer, albeit diminished compared to wild-type animals.
Dietary or ZnT3-dependent Zn(2+) stores, and intracellular Zn(2+) release from rhodopsin recycling are suggested to be involved in light-induced retinal degeneration.
Fundamental changes occur in the expression of proteins and genes important in neurotransmission and are different in the absence of vesicular zinc in ZnT3-deficient knockout mice.
This study demonistrated that zinc transporter-3 regulate the Zinc in brain.
Zinc transporters of the Slc30a/ZnT and Slc39a/Zip families play crucial roles in cell functions, mediating zinc influx to and efflux from the lumen of the secretory pathway, constitutively or in a cell-specific manner. (Review)
Deprivation of oxygen and glucose-SD produced large FluoZin-3 increases that propagated with the event, and signals were abolished in tissues from ZnT3 knockout animals lacking synaptic Zn(2+)
ZnT3 is important for zinc homeostasis modulating presynaptic MAPK signaling and is required for hippocampus-dependent memory
Data suggest that expression of zinc homeostatic proteins such as ZnT1 and 3, and metallothioneins 1 and 2, is regulated by crosstalk between synaptic and intracellular pools of Zn(2+).
The results of this study suggested that ZnT3 protein is involved in the Abeta aggregation in the cerebellum of the AbetaPP/PS1 mouse.
Age-dependent loss of transsynaptic Zn(2+) movement leads to cognitive loss, and since extracellular beta-amyloid is aggregated by this pool of Zn(2+), the genetic ablation of ZnT3 may represent a phenocopy for the synaptic and memory deficits of AD.
In hippocampal slices from zinc transporter 3 knockout mice, there was greater attenuation of GABA(A)-mediated inhibitory postsynaptic potentials during tetanic stimulation compared with slices from wild-type animals.
ZnT3 and zinc ions are present in a subpopulation of TH-positive, NPY-negative neurons in the rodent superior cervical ganglia.
ZnT3 synaptic vesicles content was reduced in AP-3-deficient neurons.
In transgenic mouse models of Alzheimer's disease synaptic ZnT3 activity may promote cerebral amyloid angiopathy by indirectly raising exchangeable Zn2+ concentrations in the perivascular spaces of the brain
Expression of zinc transporter ZnT3 in mouse choroid epithelial cells suggests that the choroid plexus plays an important role in regulation of zinc homeostasis in the brain.
Adrenalectomy causes reduction in vesicular zinc concentration and a downregulation of ZnT3 proteins in the hippocampal region, suggesting that ZnT3 is responsible for transport of zinc ions into a pool of synaptic vesicles in zinc-enriched terminals.
Involved in accumulation of zinc in synaptic vesicles.
solute carrier family 30 (zinc transporter), member 3
, solute carrier family 30 member 3
, solute carrier family 30 protein
, zinc transporter 3
, zinc transporter ZnT-3