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STEAP4 plays role in metal homeostasis is critical to the maintenance of cellular homeostasis , and in preventing the onset of metabolic disease. [review]
a down regulation of STEAP4 and up-regulation of HIF-1alpha (show HIF1A ELISA Kits) are observed in morbidly obese patients
The expression of TNFAIP9 significantly decreased in the adipose tissue of obese children, and its levels are closely related to blood lipid level, insulin (show INS ELISA Kits) resistance, and obesity.
the expression of STEAP4 was significantly downregulated in the adipose tissue of obese children.
Some SNPs of the STEAP4 gene altered the risk of developing a metabolic syndrome in the Han Chinese population.
These data suggest that STAMP2 is required for prostate cancer progression and thus may serve as a novel therapeutic target.
Our results show increased mRNA expression of STEAP4 and NGAL (show LCN2 ELISA Kits) in human visceral adipose tissue in obese patients.
Our findings revealed that STAMP2 gene polymorphisms are likely to significantly contribute to the risk of MetS in male Han Chinese population.
three polymorphisms (rs8122, rs1981529 and rs34741656) of STAMP2 gene may be not related with type 2 diabetes mellitus in Xinjiang Uygur population
STEAP4 was highly induced in human adipose cells differentiated in the presence of 1,25D.
our data demonstrated that C/EBPbeta (show CEBPB ELISA Kits) directly regulates the roles of STEAP4 and its novel variant in attenuating lipogenesis, gluconeogenesis or/and inflammation
hepatic STAMP2 plays a pivotal role in preventing HFD-induced NAFLD (show TSC2 ELISA Kits) and that STAMP2 overexpression improves hepatic steatosis and insulin (show INS ELISA Kits) resistance in NAFLD (show TSC2 ELISA Kits).
Data show that high glucose increased protein-protein interaction between Steap4 and S100B (show S100B ELISA Kits) in mesangial (MES13) cells.
STAMP2 overexpression could exert a protective effect on diabetic atherosclerosis by reducing IR and diminishing macrophage apoptosis
STAMP2 gene overexpression may improve insulin (show INS ELISA Kits) resistance via regulating macrophage polarization in visceral and brown adipose tissues.
Stamp1 (show STEAP2 ELISA Kits) and Stamp2 play critical roles in adipogenesis, but through different mechanisms. [Stamp2, mouse]
that Steap4, a member of the six-transmembrane epithelial antigen of prostate (Steap (show STEAP1 ELISA Kits)) family proteins, is an endosomal ferrireductase with a critical role in cellular iron utilization in osteoclasts.
TIARP acts as a negative regulator of arthritis by suppressing IL-6 (show IL6 ELISA Kits) production, its signaling and TNFalpha (show TNF ELISA Kits)-induced NF-kappaB (show NFKB1 ELISA Kits) signaling, resulting in enhanced apoptosis in macrophages.
Stamp2 is detected in mouse and human atherosclerotic plaques, and its deficiency promotes atherosclerosis in mice.
analysis of the regulation of hepatic six transmembrane epithelial antigen of prostate 4 (STEAP4) expression by STAT3 (show STAT3 ELISA Kits) and CCAAT/enhancer-binding protein alpha (show CEBPA ELISA Kits)
Tiarp is stimulated by tumor necrosis factor-alpha (show TNF ELISA Kits) in adipocytes.
The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, six transmembrane prostate protein 2
, six-transmembrane epithelial antigen of prostate 4
, sixTransMembrane protein of prostate 2
, tumor necrosis factor, alpha-induced protein 9
, tumor necrosis-alpha-induced adipose-related protein
, STEAP family member 4
, six transmembrane epithelial antigen of the prostate 4
, metalloreductase STEAP4-like
, Tnfa-induced adipose-related protein
, dudulin 4
, tumor necrosis factor-alpha-induced adipose-related protein