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Simian immunodeficiency virus Nef-induced inhibition of TfR (show TFRC ELISA Kits) endocytosis leads to the reduction of Transferrin (show Tf ELISA Kits) uptake and intracellular iron concentration and is accompanied by attenuated lentiviral replication in macrophages.
Knock-out of TFR1 (show TFRC ELISA Kits) in Purkinje cells reduces mGlu1 (show GRM1 ELISA Kits) expression at synapses and impairs motor coordination.
Tfrc deletion dramatically suppressed both transforming growth factor-beta (TGF-beta) and bone morphogenetic protein (BMP) signaling in cranial neural crest cell-derived mandibular tissues.
decreasing TfR1 (show TFRC ELISA Kits) expression during beta-thalassemic erythropoiesis, either directly via induced haploinsufficiency or via exogenous apotransferrin, decreases ineffective erythropoiesis and provides an endogenous mechanism to upregulate hepcidin (show HAMP ELISA Kits), leading to sustained iron-restricted erythropoiesis and preventing systemic iron overload in beta-thalassemic mice
the value of transferrin receptors (TfRs)/cell reveals a 100-fold increase in the number of TfRs per bEnd3 cells compared to human umbilical vein cells.
our study reveals that TFR (show TFRC ELISA Kits) functions as a novel regulator to control AMPA (show GRIA3 ELISA Kits) trafficking efficiency and synaptic plasticity
We found that iron assimilation via Tfr1 (show TFRC ELISA Kits) was critical for skeletal muscle metabolism, and that iron deficiency in muscle led to dramatic changes, not only in muscle, but also in adipose tissue and liver.
Mice lacking Tfr1 (show TFRC ELISA Kits) in the heart died in the second week of life and had cardiomegaly, poor cardiac function, failure of mitochondrial respiration, and ineffective mitophagy.
Transferrin Receptor 1 Facilitates Poliovirus Permeation of Mouse Brain Capillary Endothelial Cells.
Erythrocytic iron deficiency enhances susceptibility to Plasmodium chabaudi infection in mice carrying a missense mutation in tfr1 (show TFRC ELISA Kits).
Tfr1 (show TFRC ELISA Kits) has a role in homeostatic maintenance of the intestinal epithelium, acting through a role that is independent of its iron-uptake function
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis.
, transferrin receptor protein 1
, transferrin receptor 1
, mammary tumor virus receptor 1