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TFR Protein expressed in - ABIN623567
Xu, Zhu, Yang, Xu, Liu, Chen: Quantitative assessment of human serum transferrin receptor in breast cancer patients pre- and post-chemotherapy using peptide immunoaffinity enrichment coupled with targeted proteomics. in Clinica chimica acta; international journal of clinical chemistry 2015
Simian immunodeficiency virus Nef-induced inhibition of TfR (show TFRC Proteins) endocytosis leads to the reduction of Transferrin (show Tf Proteins) uptake and intracellular iron concentration and is accompanied by attenuated lentiviral replication in macrophages.
Data suggest that hematologic parameters in children consuming lacto-ovo vegetarian diets are comparable with those of control children, but ferritin (show FTL Proteins) levels are lower; inclusion of novel serum biomarkers, soluble transferrin receptor and hepcidin (show HAMP Proteins), in nutritional assessment can better detect subclinical iron deficiency in children following vegetarian diet. This study was conducted in Poland with children ages 4.5-9 years.
results suggest that lower Hepcidin-25, as well as higher sTfR and sTfR/Hepcidin-25 ratio were significant predictors of favorable hemoglobin response within a month after IV administration of ferric carboxymaltose in patients with CKD
TfR1 (show TFRC Proteins) was highly expressed in glioblastomas and associated with shorter survival in the whole cohort, but not in the individual malignancy grades
Expression of Hepcidin (show HAMP Proteins) and Ferroportin (show SLC40A1 Proteins) in the Placenta, and Ferritin (show FTL Proteins) and Transferrin Receptor 1 Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes
Transferrin (show Tf Proteins) facilitates the formation of DNA double-strand breaks (DNA-DSBs) via transferrin receptor TfR1 but not TfR2 (show TFR2 Proteins).
Human melanoma cells are able to up-regulate TFRC (show TFRC Proteins) expression using hyaluronan/CD44 (show CD44 Proteins) signaling.
high expression of transferrin receptor-1 resulting in iron uptake contributes to increase in the labile iron pool which plays roles in cholangiocarcinoma progression with aggressive clinical outcomes.
EGFR (show EGFR Proteins) regulates iron homeostasis to promote non-small cell lung cancer growth through redistribution of transferrin receptor 1.
TFR1 (show TFRC Proteins) is overexpressed in adult T-cell leukemia/lymphoma caells .
NSF (show NSF Proteins) deficiency in HeLa cells barely affected cell viability, anterograde trafficking of vesicular stomatitis virus glycoprotein G and transferrin (show Tf Proteins) endocytosis.
Knock-out of TFR1 (show TFRC Proteins) in Purkinje cells reduces mGlu1 (show GRM1 Proteins) expression at synapses and impairs motor coordination.
Tfrc deletion dramatically suppressed both transforming growth factor-beta (TGF-beta) and bone morphogenetic protein (BMP) signaling in cranial neural crest cell-derived mandibular tissues.
decreasing TfR1 (show TFRC Proteins) expression during beta-thalassemic erythropoiesis, either directly via induced haploinsufficiency or via exogenous apotransferrin, decreases ineffective erythropoiesis and provides an endogenous mechanism to upregulate hepcidin (show HAMP Proteins), leading to sustained iron-restricted erythropoiesis and preventing systemic iron overload in beta-thalassemic mice
the value of transferrin receptors (TfRs)/cell reveals a 100-fold increase in the number of TfRs per bEnd3 cells compared to human umbilical vein cells.
our study reveals that TFR (show TFRC Proteins) functions as a novel regulator to control AMPA (show GRIA3 Proteins) trafficking efficiency and synaptic plasticity
We found that iron assimilation via Tfr1 (show TFRC Proteins) was critical for skeletal muscle metabolism, and that iron deficiency in muscle led to dramatic changes, not only in muscle, but also in adipose tissue and liver.
Mice lacking Tfr1 (show TFRC Proteins) in the heart died in the second week of life and had cardiomegaly, poor cardiac function, failure of mitochondrial respiration, and ineffective mitophagy.
Transferrin Receptor 1 Facilitates Poliovirus Permeation of Mouse Brain Capillary Endothelial Cells.
Erythrocytic iron deficiency enhances susceptibility to Plasmodium chabaudi infection in mice carrying a missense mutation in tfr1 (show TFRC Proteins).
Tfr1 (show TFRC Proteins) has a role in homeostatic maintenance of the intestinal epithelium, acting through a role that is independent of its iron-uptake function
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis.
, transferrin receptor protein 1
, transferrin receptor 1
, mammary tumor virus receptor 1