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TFR Protein expressed in - ABIN623567
Xu, Zhu, Yang, Xu, Liu, Chen: Quantitative assessment of human serum transferrin receptor in breast cancer patients pre- and post-chemotherapy using peptide immunoaffinity enrichment coupled with targeted proteomics. in Clinica chimica acta; international journal of clinical chemistry 2015
Simian immunodeficiency virus Nef-induced inhibition of TfR (show TFRC Proteins) endocytosis leads to the reduction of Transferrin (show Tf Proteins) uptake and intracellular iron concentration and is accompanied by attenuated lentiviral replication in macrophages.
Our data provide evidence that blocking TfR (show TFRC Proteins) could significantly inhibit lung adenocarcinoma (LAC (show LCT Proteins)) proliferation by targeting the oncogene (show RAB1A Proteins) KRAS; therefore, TfR (show TFRC Proteins) may be a therapeutic target for LAC (show LCT Proteins). In addition, our results suggest a new method for blocking the signal from the oncogene (show RAB1A Proteins) KRAS by targeting TfR (show TFRC Proteins) in LAC (show LCT Proteins).
TfR (show TFRC Proteins) could be used as a marker of erythropoiesis in high-flux hemodialysis patients
The results suggest a role of microRNAs in the TfR1 regulation in the iron-regulatory protein-iron-responsive element system.
Cell viability and surface expression of transferrin receptor (CD71) and glycophorin A (GPA (show GYPA Proteins)) were analyzed before and after re-culture by flow cytometry. These studies show differential sensitivities of these surface proteins on K562 cells to proteases, and suggest molecular mechanisms of transmembrane protein transport and cycling.
In agreement with previous studies with truncated forms of these receptors, holo-Tf binds to the TfR1 (show TFRC Proteins) homologue significantly stronger than to TfR2 (show TFR2 Proteins).
These data show that TfR1 (show TFRC Proteins)-PvRBP2b invasion pathway is critical for the recognition of reticulocytes during P. vivax invasion.
combination of desferal with oxaliplatin can overcome cervical cancer oxaliplatin resistance through the regulation of hCtr1 (show SLC31A1 Proteins) and TfR1 (show TFRC Proteins)
Data suggest that hematologic parameters in children consuming lacto-ovo vegetarian diets are comparable with those of control children, but ferritin (show FTL Proteins) levels are lower; inclusion of novel serum biomarkers, soluble transferrin receptor and hepcidin (show HAMP Proteins), in nutritional assessment can better detect subclinical iron deficiency in children following vegetarian diet. This study was conducted in Poland with children ages 4.5-9 years.
results suggest that lower Hepcidin-25, as well as higher sTfR and sTfR/Hepcidin-25 ratio were significant predictors of favorable hemoglobin response within a month after IV administration of ferric carboxymaltose in patients with CKD
TfR1 (show TFRC Proteins) was highly expressed in glioblastomas and associated with shorter survival in the whole cohort, but not in the individual malignancy grades
duodenal Regnase-1 controls the expression of PHD3 (show EGLN3 Proteins), which impairs duodenal iron uptake via HIF2alpha (show EPAS1 Proteins) suppression.
Knock-out of TFR1 (show TFRC Proteins) in Purkinje cells reduces mGlu1 (show GRM1 Proteins) expression at synapses and impairs motor coordination.
Tfrc deletion dramatically suppressed both transforming growth factor-beta (TGF-beta) and bone morphogenetic protein (BMP) signaling in cranial neural crest cell-derived mandibular tissues.
decreasing TfR1 (show TFRC Proteins) expression during beta-thalassemic erythropoiesis, either directly via induced haploinsufficiency or via exogenous apotransferrin, decreases ineffective erythropoiesis and provides an endogenous mechanism to upregulate hepcidin (show HAMP Proteins), leading to sustained iron-restricted erythropoiesis and preventing systemic iron overload in beta-thalassemic mice
the value of transferrin receptors (TfRs)/cell reveals a 100-fold increase in the number of TfRs per bEnd3 cells compared to human umbilical vein cells.
our study reveals that TFR (show TFRC Proteins) functions as a novel regulator to control AMPA (show GRIA3 Proteins) trafficking efficiency and synaptic plasticity
We found that iron assimilation via Tfr1 (show TFRC Proteins) was critical for skeletal muscle metabolism, and that iron deficiency in muscle led to dramatic changes, not only in muscle, but also in adipose tissue and liver.
Mice lacking Tfr1 (show TFRC Proteins) in the heart died in the second week of life and had cardiomegaly, poor cardiac function, failure of mitochondrial respiration, and ineffective mitophagy.
Transferrin Receptor 1 Facilitates Poliovirus Permeation of Mouse Brain Capillary Endothelial Cells.
Erythrocytic iron deficiency enhances susceptibility to Plasmodium chabaudi infection in mice carrying a missense mutation in tfr1 (show TFRC Proteins).
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis.
, transferrin receptor protein 1
, transferrin receptor 1
, mammary tumor virus receptor 1