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|Antigen||X-Linked Inhibitor of Apoptosis (XIAP) Antibodies|
|Epitope||AA 230-280 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This XIAP antibody is un-conjugated Alternatives|
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|4 references available|
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Product Details anti-XIAP AntibodyTarget Details XIAP Application Details Handling References for anti-XIAP antibody (ABIN674364) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from mouse XIAP|
Target Details XIAPProduct Details anti-XIAP Antibody Application Details Handling References for anti-XIAP antibody (ABIN674364) Images back to top
|Alternative Name||Xiap (XIAP Antibody Abstract)|
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Aipa, Api3, IAP3, MIHA, Birc4, ILP-1, 11115C2Rik, E3 ubiquitin-protein ligase XIAP, Baculoviral IAP repeat-containing protein 4, IAP homolog A, Inhibitor of apoptosis protein 3, IAP-3, mIAP-3, mIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP, Xiap
|Pathways||Apoptosis, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis|
Application DetailsProduct Details anti-XIAP Antibody Target Details XIAP Handling References for anti-XIAP antibody (ABIN674364) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-XIAP Antibody Target Details XIAP Application Details References for anti-XIAP antibody (ABIN674364) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-XIAP antibody (ABIN674364)Product Details anti-XIAP Antibody Target Details XIAP Application Details Handling Images back to top
|Product cited in:||
Sun, Liu, Zou, Lan, Sun, Wang, Zhao, Jiang, Liu: "Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer." in: Journal of bioenergetics and biomembranes, 2015 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Jin, Lan, Han, Sun, Liu, Zhang, Liu, Zhang, Hu, Liu, Wang: "Smac mimetic?induced caspase?independent necroptosis requires RIP1 in breast cancer." in: Molecular medicine reports, 2015
Chen, Xie, Zhao, Wang, Bai, Yin, Jiang, Xie, Jia, Huang et al.: "Ampelopsin induces apoptosis by regulating multiple c?Myc/S?phase kinase?associated protein 2/F?box and WD repeat?containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma ..." in: Molecular medicine reports, Vol. 11, Issue 1, pp. 105-12, 2014 Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Human).
Chen, Bai, Zhong, Xie, Long, Yang, Wu, Jia, Wang: "Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7? and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549." in: PLoS ONE, Vol. 8, Issue 11, pp. e79201, 2013
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